Admin Core

核心A项目总结 核心A(行政核心)的目的是提供组织框架以优化实施 本计划项目申请中提出的多项目研究计划，这是一项旨在理解 68-1人巨细胞病毒猴免疫缺陷病毒疫苗独特的“复制抑制”效应 人类巨细胞病毒(HCMV)/人类下游临床发展的载体 目前处于第一阶段临床测试的免疫缺陷病毒(HIV)载体。这一框架将提供 对方案的科学领导和整合，以及对方案的行政支持和援助 项目总监和项目负责人。这种支持和援助包括在以下方面提供后勤支持 行政和文书事务，促进项目和核心领导之间的互动，并提供 决策论坛、数据库维护和管理、数据管理和共享、试验性论坛 规划、统计分析、法规遵从性协助、手稿撰写和提交、进度 提交报告、财务跟踪和管理，以及组织一个外部咨询委员会 评估项目的进展和总体方向。 这一核心的具体目标是： 1.确保一个互动的环境，并在项目科学家之间培养凝聚力强、专注的关系 并为项目和核心领导提供一个论坛，以通过以下方式设定总体优先事项和做出关键决策 定期开会和视频会议。 2.通过建立外部咨询委员会(EAC)促进方案的科学进步 审查该计划的进展情况，并提供独立的科学和临床开发监督。 3.为以下方面提供财政监督和一般行政、预算、数据库和统计支助 总体规划， 4.与NIAID项目官员和其他NIAID工作人员保持沟通，协调向 NIH和EAC，并确保遵守NIH和当地制度要求。

CORE A PROJECT SUMMARY The purpose of Core A (Administrative Core) is to provide the organizational framework to optimally implement the multi-project research program proposed in this Program Project application, a grant that seeks to understand the unique “replication arrest” efficacy of 68-1 RhCMV-based Simian Immunodeficiency virus (SIV) vaccine vectors as a guide to downstream clinical development of the Human Cytomegalovirus (HCMV)/ Human Immunodeficiency virus (HIV) vectors that are currently in Phase 1 clinical testing. This framework will provide scientific leadership and integration of the Program, as well as administrative support and assistance to the Program Director and Project Leaders. This support and assistance includes providing logistical support on administrative and clerical matters, facilitating interactions between Project and Core Leaders and providing a forum for decision making, database maintenance and administration, data curation and sharing, experimental planning, statistical analysis, regulatory compliance assistance, manuscript writing and submission, progress report submission, and financial tracking and management, as well as organizing an external advisory committee to evaluate the progress and overall direction of the program. The specific aims of this Core are: 1. To ensure an interactive environment and foster a cohesive, focused relationship among Program scientists and to provide a forum for Project and Core Leaders to set overall priorities and make key decisions via regular meetings and videoconferences. 2. To promote scientific advancement of the Program by establishing an external advisory committee (EAC) to review the progress of the program, and provide independent scientific and clinical development oversight. 3. To provide fiscal oversight and general administrative, budgetary, database, and statistical support for the overall program, 4. To maintain communication with the NIAID program officer and other NIAID staff, coordinate reports to the NIH and EAC and ensure compliance with NIH and local institutional requirements.