Admin Core

管理核心

• 批准号: 10709003
• 负责人: Louis J. Picker
• 金额: $ 20.17万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709003
• 关键词: Advisory Committees; Charge; Communication; Cytomegalovirus; Databases; Decision Making; Ensure; Fostering; Grant; HIV; Human; Human Resources; Immunologics; Institution; Leadership; Maintenance; Manuscripts; National Institute of Allergy and Infectious Disease; Phase; Program Research Project Grants; Progress Reports; Qualifying; Quality Control; Reporting; SIV Vaccines; Scientific Advances and Accomplishments; Scientific Evaluation; Scientist; Statistical Data Interpretation; Supervision; Travel; United States National Institutes of Health; Visit; Writing; clinical development; collaborative environment; data curation; data sharing; meetings; programs; research clinical testing; success; vector; vector vaccine; videoconference

CORE A PROJECT SUMMARY The purpose of Core A (Administrative Core) is to provide the organizational framework to optimally implement the multi-project research program proposed in this Program Project application, a grant that seeks to understand the unique “replication arrest” efficacy of 68-1 RhCMV-based Simian Immunodeficiency virus (SIV) vaccine vectors as a guide to downstream clinical development of the Human Cytomegalovirus (HCMV)/ Human Immunodeficiency virus (HIV) vectors that are currently in Phase 1 clinical testing. This framework will provide scientific leadership and integration of the Program, as well as administrative support and assistance to the Program Director and Project Leaders. This support and assistance includes providing logistical support on administrative and clerical matters, facilitating interactions between Project and Core Leaders and providing a forum for decision making, database maintenance and administration, data curation and sharing, experimental planning, statistical analysis, regulatory compliance assistance, manuscript writing and submission, progress report submission, and financial tracking and management, as well as organizing an external advisory committee to evaluate the progress and overall direction of the program. The specific aims of this Core are: 1. To ensure an interactive environment and foster a cohesive, focused relationship among Program scientists and to provide a forum for Project and Core Leaders to set overall priorities and make key decisions via regular meetings and videoconferences. 2. To promote scientific advancement of the Program by establishing an external advisory committee (EAC) to review the progress of the program, and provide independent scientific and clinical development oversight. 3. To provide fiscal oversight and general administrative, budgetary, database, and statistical support for the overall program, 4. To maintain communication with the NIAID program officer and other NIAID staff, coordinate reports to the NIH and EAC and ensure compliance with NIH and local institutional requirements.

核心A项目总结 核心A（行政核心）的目的是提供组织框架， 本计划项目申请中提出的多项目研究计划，旨在了解 猴免疫缺陷病毒（SIV）68-1 RhCMV疫苗独特“复制阻滞”效应 载体作为人巨细胞病毒（HCMV）/人 免疫缺陷病毒（HIV）载体，目前处于第1阶段临床试验。该框架将提供 科学的领导和整合计划，以及行政支持和援助， 项目经理和项目领导人。这种支持和援助包括提供后勤支助， 行政和文书事务，促进项目和核心领导人之间的互动，并提供一个 决策论坛、数据库维护和管理、数据管理和共享、实验 规划、统计分析、法规遵从性协助、手稿撰写和提交、进展 报告提交、财务跟踪和管理，以及组织外部咨询委员会 评估项目的进展和总体方向。 该核心的具体目标是： 1.确保互动的环境，并在项目科学家之间培养有凝聚力、有重点的关系 并为项目和核心领导人提供一个论坛，以通过以下方式确定总体优先事项并做出关键决策 定期会议和视频会议。 2.通过建立外部咨询委员会（EAC）促进该计划的科学进步， 审查项目的进展，并提供独立的科学和临床开发监督。 3.提供财政监督和一般行政，预算，数据库和统计支持， 总体方案， 4.保持与NIAID项目官员和其他NIAID工作人员的沟通，协调报告， NIH和EAC，并确保符合NIH和当地机构的要求。