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2/3-Genetic Analysis of the International Cohort Collection for Bipolar Disorder

双相情感障碍国际队列的 2/3 基因分析

基本信息

批准号：
8861932
负责人：
Steven Andrew McCarroll
金额：
$ 17.7万
依托单位：
BROAD INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-15 至 2018-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8861932
关键词：
Affect Affective African American Age of Onset Alleles Architecture Biology Bipolar Disorder Boston California Cataloging Catalogs ChIP-seq Characteristics Chronic Clinical Clinical Data Code Collaborations Collection Complex Copy Number Polymorphism DNA Library DRD2 gene Data Data Analyses Detection Differential Diagnosis Dimensions Disease Dopamine Receptor Etiology European Funding General Hospitals Generations Genes Genetic Genetic Fingerprintings Genetic Heterogeneity Genetic Polymorphism Genomics Genotype Goals Grant Human Individual Institutes International Investments Joints Knowledge Latino Learning Major Depressive Disorder Maps Massachusetts Measures Memory Mental disorders Meta-Analysis Methods Modeling Moods National Institute of Mental Health Neurocognition Neurocognitive Neuropharmacology Nucleotides Panic Disorder Pathway interactions Personality Phenotype Philanthropic Fund Psychotic Disorders Quality Control Research Research Personnel Risk Risk Factors Sample Size Sampling Sampling Studies Schizophrenia Single Nucleotide Polymorphism Site Statistical Methods Subgroup Substance Use Disorder Suicide Time Universities Variant Work affective psychoses base case control cognitive ability cohort cost effective disorder risk disorder subtype exome exome sequencing genetic analysis genetic association genome wide association study genome-wide genotyping technology indexing innovation insight novel predictive modeling processing speed rare variant response risk variant sample collection

项目摘要

DESCRIPTION (provided by applicant): The grant, "Genetic Analysis of the International Cohort Collection for Bipolar Disorder", is continuation of a long-standing collaborative effort funded in response to an RFA for sample collections in bipolar disorder. We are thus submitting the current new application from the original group of investigators to continue the collaboration and proceed to its next logical step analyses of data being generated. We developed the "International Cohort Collection for Bipolar Disorder" in response to a NIMH FOA MH08-130. Under the auspices of R01MH085542 (Smoller/Sklar, PIs) and philanthropic funding we implemented a phenotypically robust, rapid, and cost effective method for sample collection. During the five years of the grant we have banked DNA from ~18,000 cases and 16,000 controls never previously used for genomic study of bipolar disorder (BD). We propose here enhanced aims in a unique sample to increase our knowledge of BD and to keep this highly productive team intact. The samples studied here will more than double the available samples for GWAS, and will be among the first to analyze rare variants using exome chip and exome sequencing. These analyses will provide substantially enhanced power for detection of networks and loci that confer BD risk. In Aim 1 we will perform a genomic characterization of an independent cohort of 15,800 cases and 18,598 controls to identify high confidence genetic loci for risk of BD through association study of common single nucleotide polymorphisms, copy number variants, and rare single nucleotide variants. We will further use the data to explore genetic prediction models for BD for two specific clinical scenarios. In Aim 2 we will apply these data to characterize the spectrum of genotype-phenotype relationships by examining phenotypic subgroups, cross- disorder relationships, quantitative personality dimensions, and neurocognition. Our goal is to learn more about the genetics of BD and how genes might act to alter disease risk. We propose to do this using the largest and most comprehensively studied sample collection in the field that includes both genetic and phenotypic risk factors.