Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)

描述（由申请人提供）：宾夕法尼亚州立大学烟草监管科学中心（TCORS）的总体目标是开发领先的最先进的研究和培训基础设施，为烟草产品监管政策提供信息。为了实现这些目标，PSTCORS正在将宾夕法尼亚州立大学医学院的资源与宾夕法尼亚州州立大学、哈佛大学和乔治华盛顿大学的主要大学公园校园结合起来。宾夕法尼亚州立大学的一些设施将用于促进创新研究和培训，包括新建的吸烟实验室，MRI实验室和我们的NIH资助的临床和转化科学研究所。TCORS将使我们能够增加额外的专业知识，例如吸烟生物标志物核心实验室，该实验室将为所有TCORS进行烟草科学的专门分析。我们的TCORS的一个中心主题是烟草监管科学在弱势群体（如社会经济地位低，精神障碍）和少数群体的研究。这将通过三个互补的研究项目来实现，这些项目共享共同的方法，共同的核心多学科方法和共同的领导力，其总体目标是烟草监管政策的相关性。宾夕法尼亚州立大学认识到烟草监管研究卓越中心的一般需求，并大力支持其研究和培训的跨学科努力和多样性 和教育项目。这一承诺将通过为烟草管制学者制定一个专门的教育计划和一个试点项目计划来实现，该计划旨在促进测试和研究烟草危害的创新思想和研究方法。宾夕法尼亚州立大学世界校园将促进我们在培训烟草监管研究方面的年轻科学家以及与其他TCORS合作方面的努力。这些努力旨在今后维持TCORS概念。 相关性：香烟占美国消费的所有可燃烟草烟雾产品的90%，是可避免疾病的最重要原因。宾夕法尼亚州立大学TCORS将评估吸烟者从常规香烟转换为尼古丁含量较低的香烟对尼古丁依赖和烟草危害的健康影响。如果安全有效，这一策略将带来巨大的公共卫生效益。

DESCRIPTION (provided by applicant): The overall goal of the Penn State Tobacco Center of Regulatory Science (TCORS) is to develop a leading state-of-the-art research and training infrastructure that will inform policy on the regulation of tobacco products. To achieve these goals, the PSTCORS is uniting the resources of the Penn State College of Medicine with the main University Park campus in State College, PA, Harvard University and George Washington University. A number of Penn State's facilities will be utilized to foster innovative research and training including a newly built smoking laboratory, MRI labs, and our NIH-funded Clinical &Translational Science Institute. The TCORS will allow us to add additional expertise, such as a Smoking Biomarkers Core Laboratory that will perform specialized assays for tobacco science for all TCORS. A central theme of our TCORS is the study of tobacco regulatory science in vulnerable (e.g. low socioeconomic status, mental disorders) and minority populations. This will be accomplished through three complementary research projects that share common methodologies, common core multidisciplinary approaches, and common leadership with the overarching aim of relevancy for tobacco regulatory policies. Penn State University recognizes the more general needs of a Centers for Excellence for tobacco regulatory research in general and strongly supports interdisciplinary efforts and diversity in both its research and its training and educational programs. This commitment will be realized through the development of a dedicated educational program for tobacco regulation scholars and a pilot project program that fosters innovative ideas and research methods for testing and studying tobacco harm. The Penn State World Campus will facilitate our efforts in training young scientists in tobacco regulatory research and collaborating with other TCORS. These efforts are designed to sustain the TCORS concept in the future. RELEVANCE: Cigarettes constitute 90% of all combustible tobacco smoke products consumed in the United States and are the single most important cause of avoidable diseases. The Penn State TCORS will evaluate the health effects of switching smokers from their usual cigarettes to reduced nicotine cigarettes on nicotine dependence and tobacco harm. If safe and effective, this strategy will have large public health benefits.