Does Switching to Nicotine-containing Electronic Cigarettes Reduce Health Risk Markers?
改用含尼古丁的电子烟会减少健康风险标志吗?
基本信息
- 批准号:10294089
- 负责人:
- 金额:$ 9.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-15 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcademyAdultAfrican AmericanApplications GrantsAreaAssessment toolBehaviorBehavioralBiostatistical MethodsCancer EtiologyCause of DeathCessation of lifeCigaretteClinicalClinical TrialsDataDevelopmentDiseaseEconomic FactorsEducationElectronic cigaretteEmploymentEnrollmentEthnic OriginEthnic groupFutureGoalsGrantHealthHealth InsuranceHealthy People 2020HousingIncomeMeasuresMedicineMental HealthMethodsMinority GroupsNational Institute of Drug AbuseNeighborhood Health CenterNeighborhoodsNicotineNicotine DependenceNot Hispanic or LatinoParentsParticipantPatient Self-ReportPatientsPopulationPovertyPrevalenceProtocols documentationPublicationsQuestionnairesRaceReportingResearchResearch PersonnelResearch TrainingResourcesRiskRisk MarkerSecuritySeriesSmokerSmokingStandardizationStressSubstance abuse problemTobaccoTobacco useTrainingTransportationUnderrepresented MinorityUrsidae FamilyVisitVulnerable PopulationsWritingadverse childhood eventsbehavioral economicscigarette smokingclinical trial enrollmentcombustible cigaretteeconomic needexperiencehealth assessmenthealth care availabilityhealth disparityinnovationinstrumentmortalityneighborhood safetyparent grantparticipant retentionprematureresponseresponsible research conductscreeningsmoking prevalencesocialsocial factorssocial health determinantssocioeconomic disadvantagetooltransportation accesstreatment services
项目摘要
Project Summary/Abstract for Diversity Supplement
The candidate of this Research Supplement to Promote Diversity in Health-Related Research (Diversity
Supplement) (Dr. Sophia Allen) will investigate the social and economic factors that may influence clinical trial
enrollment and retention of participants in the parent grant (U01-DA045517) and determine if these same
factors are associated with participants’ ability to switch from traditional cigarettes to a NIDA Standardized
Research Electronic Cigarette (SREC). Cigarette smoking is the leading cause of preventable disease and
premature death in the U.S. yet vulnerable and minority populations (e.g., socioeconomic disadvantage,
African Americans, etc.) bear a disproportionate burden of tobacco-caused disease. The disproportionate
impact from smoking has been attributed to low utilization of cessation treatment services, less access to
health care, and the underrepresentation of minority populations in clinical trials, all of which may be influenced
by the Social Determinants of Health (SDoH). National initiatives such as Healthy People 2020 and the
National Academy of Medicine reports have identified SDoH as a priority for better understanding health
disparities. Thus, using tools to identify the environmental, behavioral, and social causes and consequences of
nicotine addiction may help to reduce the adverse health effects of traditional cigarette smoking. To date, there
is no data available on the SDoH, clinical trial enrollment, retention, and the ability to switch from traditional
cigarettes to an electronic cigarette such as the NIDA Standardized Research Electronic Cigarette (SREC). We
have developed an assessment tool adapted from the Protocol for Responding to and Assessing Patients’
Assets, Risks, and Experiences (PRAPARE) instrument and the Adverse Childhood Experiences (ACEs)
questionnaire to gain a comprehensive understanding of participants’ social and economic needs. Standard
core measures will be collected and responses from the adapted PRAPARE instrument will be analyzed by Dr.
Allen to measure enrollment, retention and the ability of participants to switch from traditional cigarettes to a
SREC. The proposed supplemental study will inform the parent study by providing a potential explanatory
mechanism for participants’ ability to transition to an e-cigarette while also identifying health disparities among
vulnerable and minority populations. The overarching goal of this Diversity Supplement is for Dr. Allen, to gain
research experience as a postdoctoral trainee and transition to an independent investigator in substance
abuse (nicotine) research with a focus on health disparities. The candidate’s proposed four areas of focus
include: (1) clinical trials research training and experience; (2) biostatistical methods; (3) research publications
and grant writing; and (4) responsible conduct of research. Together, this training and experience will allow Dr.
Allen to develop K-series and subsequent R-series grant applications.
项目摘要/多样性摘要补充资料
这份促进健康相关研究多样性的研究副刊的候选人
(索菲亚·艾伦博士)将调查可能影响临床试验的社会和经济因素
家长助学金(U01-DA045517)中参与者的登记和保留,并确定这些是否相同
这些因素与参与者从传统香烟转向NIDA标准化香烟的能力有关
研究电子烟(SREC)。吸烟是可预防疾病的主要原因,
在美国,过早死亡仍然是弱势和少数群体(例如,社会经济上的劣势,
非裔美国人等)承担着不成比例的烟草引起的疾病的负担。不成比例的
吸烟的影响被归因于戒烟治疗服务的低利用率,更少的获得
医疗保健,以及少数群体在临床试验中代表性不足,所有这些都可能受到影响
健康的社会决定因素(SDoH)。国家倡议,如健康人2020和
美国国家医学科学院的报告将SDOH确定为更好地了解健康的优先事项
差距。因此,使用工具来确定环境、行为和社会原因和后果
尼古丁成瘾可能有助于减少传统吸烟对健康的不利影响。到目前为止,有
是否没有有关SDoH、临床试验登记、保留以及从传统
从香烟到电子烟,如NIDA标准化研究电子烟(SREC)。我们
开发了一种根据议定书改编的评估工具,用于响应和评估患者的
资产、风险和经历(PRAPARE)工具与不良童年经历(ACE)
问卷调查,以全面了解参与者的社会和经济需求。标准
将收集核心措施,并由Dr分析改装后的PRAPARE仪器的反应。
Allen将衡量参与者的登记、保留和从传统香烟转向
SREC。拟议的补充研究将通过提供潜在的解释性说明来通知家长研究
为参与者过渡到电子烟的能力提供机制,同时还确定
弱势群体和少数群体。这份多样性副刊的首要目标是让艾伦博士获得
作为博士后实习生的研究经历和实质上向独立研究员的过渡
滥用(尼古丁)研究,重点是健康差异。候选人提出的四个重点领域
包括:(1)临床试验、研究、培训和经验;(2)生物统计学方法;(3)研究出版物
以及(4)负责任的研究行为。总而言之,这种培训和经验将使Dr。
艾伦将开发K系列和随后的R系列赠款申请。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JONATHAN FOULDS其他文献
JONATHAN FOULDS的其他文献
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{{ truncateString('JONATHAN FOULDS', 18)}}的其他基金
Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction
宾夕法尼亚州立大学 TCORS:烟草产品成分对毒性和成瘾性的影响
- 批准号:
10665895 - 财政年份:2023
- 资助金额:
$ 9.27万 - 项目类别:
Project 3: Randomized Placebo-controlled Trial of Nicotine Pouches in Smokers
项目 3:吸烟者尼古丁袋的随机安慰剂对照试验
- 批准号:
10665898 - 财政年份:2023
- 资助金额:
$ 9.27万 - 项目类别:
Randomized trial of low nicotine cigarettes plus electronic cigarettes in smokers with a mental health condition
对有心理健康状况的吸烟者进行低尼古丁香烟加电子烟的随机试验
- 批准号:
10229461 - 财政年份:2019
- 资助金额:
$ 9.27万 - 项目类别:
Does Switching to Nicotine-containing Electronic Cigarettes Reduce Health Risk Markers?
改用含尼古丁的电子烟会减少健康风险标志吗?
- 批准号:
9752508 - 财政年份:2018
- 资助金额:
$ 9.27万 - 项目类别:
Random nicotine delivery: A novel intervention for smokers
随机尼古丁输送:针对吸烟者的新型干预措施
- 批准号:
8809791 - 财政年份:2014
- 资助金额:
$ 9.27万 - 项目类别:
Random nicotine delivery: A novel intervention for smokers
随机尼古丁输送:针对吸烟者的新型干预措施
- 批准号:
8925844 - 财政年份:2014
- 资助金额:
$ 9.27万 - 项目类别:
Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety p248-288
项目 2:减少情绪和焦虑吸烟者的尼古丁香烟 p248-288
- 批准号:
8737840 - 财政年份:2014
- 资助金额:
$ 9.27万 - 项目类别:
Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)
宾夕法尼亚州立大学烟草监管科学中心 (TCORS)
- 批准号:
8919320 - 财政年份:2013
- 资助金额:
$ 9.27万 - 项目类别:
Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)
宾夕法尼亚州立大学烟草监管科学中心 (TCORS)
- 批准号:
8582174 - 财政年份:2013
- 资助金额:
$ 9.27万 - 项目类别:
Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety p248-288
项目 2:减少情绪和焦虑吸烟者的尼古丁香烟 p248-288
- 批准号:
8594387 - 财政年份:2013
- 资助金额:
$ 9.27万 - 项目类别:
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