Does Switching to Nicotine-containing Electronic Cigarettes Reduce Health Risk Markers?

改用含尼古丁的电子烟会减少健康风险标志吗?

基本信息

项目摘要

Project Summary/Abstract for Diversity Supplement The candidate of this Research Supplement to Promote Diversity in Health-Related Research (Diversity Supplement) (Dr. Sophia Allen) will investigate the social and economic factors that may influence clinical trial enrollment and retention of participants in the parent grant (U01-DA045517) and determine if these same factors are associated with participants’ ability to switch from traditional cigarettes to a NIDA Standardized Research Electronic Cigarette (SREC). Cigarette smoking is the leading cause of preventable disease and premature death in the U.S. yet vulnerable and minority populations (e.g., socioeconomic disadvantage, African Americans, etc.) bear a disproportionate burden of tobacco-caused disease. The disproportionate impact from smoking has been attributed to low utilization of cessation treatment services, less access to health care, and the underrepresentation of minority populations in clinical trials, all of which may be influenced by the Social Determinants of Health (SDoH). National initiatives such as Healthy People 2020 and the National Academy of Medicine reports have identified SDoH as a priority for better understanding health disparities. Thus, using tools to identify the environmental, behavioral, and social causes and consequences of nicotine addiction may help to reduce the adverse health effects of traditional cigarette smoking. To date, there is no data available on the SDoH, clinical trial enrollment, retention, and the ability to switch from traditional cigarettes to an electronic cigarette such as the NIDA Standardized Research Electronic Cigarette (SREC). We have developed an assessment tool adapted from the Protocol for Responding to and Assessing Patients’ Assets, Risks, and Experiences (PRAPARE) instrument and the Adverse Childhood Experiences (ACEs) questionnaire to gain a comprehensive understanding of participants’ social and economic needs. Standard core measures will be collected and responses from the adapted PRAPARE instrument will be analyzed by Dr. Allen to measure enrollment, retention and the ability of participants to switch from traditional cigarettes to a SREC. The proposed supplemental study will inform the parent study by providing a potential explanatory mechanism for participants’ ability to transition to an e-cigarette while also identifying health disparities among vulnerable and minority populations. The overarching goal of this Diversity Supplement is for Dr. Allen, to gain research experience as a postdoctoral trainee and transition to an independent investigator in substance abuse (nicotine) research with a focus on health disparities. The candidate’s proposed four areas of focus include: (1) clinical trials research training and experience; (2) biostatistical methods; (3) research publications and grant writing; and (4) responsible conduct of research. Together, this training and experience will allow Dr. Allen to develop K-series and subsequent R-series grant applications.
多样性补编项目摘要/摘要

项目成果

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JONATHAN FOULDS其他文献

JONATHAN FOULDS的其他文献

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{{ truncateString('JONATHAN FOULDS', 18)}}的其他基金

Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction
宾夕法尼亚州立大学 TCORS:烟草产品成分对毒性和成瘾性的影响
  • 批准号:
    10665895
  • 财政年份:
    2023
  • 资助金额:
    $ 9.27万
  • 项目类别:
Project 3: Randomized Placebo-controlled Trial of Nicotine Pouches in Smokers
项目 3:吸烟者尼古丁袋的随机安慰剂对照试验
  • 批准号:
    10665898
  • 财政年份:
    2023
  • 资助金额:
    $ 9.27万
  • 项目类别:
Randomized trial of low nicotine cigarettes plus electronic cigarettes in smokers with a mental health condition
对有心理健康状况的吸烟者进行低尼古丁香烟加电子烟的随机试验
  • 批准号:
    10229461
  • 财政年份:
    2019
  • 资助金额:
    $ 9.27万
  • 项目类别:
Does Switching to Nicotine-containing Electronic Cigarettes Reduce Health Risk Markers?
改用含尼古丁的电子烟会减少健康风险标志吗?
  • 批准号:
    9752508
  • 财政年份:
    2018
  • 资助金额:
    $ 9.27万
  • 项目类别:
Random nicotine delivery: A novel intervention for smokers
随机尼古丁输送:针对吸烟者的新型干预措施
  • 批准号:
    8809791
  • 财政年份:
    2014
  • 资助金额:
    $ 9.27万
  • 项目类别:
Random nicotine delivery: A novel intervention for smokers
随机尼古丁输送:针对吸烟者的新型干预措施
  • 批准号:
    8925844
  • 财政年份:
    2014
  • 资助金额:
    $ 9.27万
  • 项目类别:
Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety p248-288
项目 2:减少情绪和焦虑吸烟者的尼古丁香烟 p248-288
  • 批准号:
    8737840
  • 财政年份:
    2014
  • 资助金额:
    $ 9.27万
  • 项目类别:
Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)
宾夕法尼亚州立大学烟草监管科学中心 (TCORS)
  • 批准号:
    8919320
  • 财政年份:
    2013
  • 资助金额:
    $ 9.27万
  • 项目类别:
Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)
宾夕法尼亚州立大学烟草监管科学中心 (TCORS)
  • 批准号:
    8582174
  • 财政年份:
    2013
  • 资助金额:
    $ 9.27万
  • 项目类别:
Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety p248-288
项目 2:减少情绪和焦虑吸烟者的尼古丁香烟 p248-288
  • 批准号:
    8594387
  • 财政年份:
    2013
  • 资助金额:
    $ 9.27万
  • 项目类别:

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一种神经影像学方法,可促进对年轻非洲裔美国电子烟使用者烟草使用升级风险的机制理解
  • 批准号:
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    10535890
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    2022
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    $ 9.27万
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A neuroimaging approach to advance mechanistic understanding of tobacco use escalation risk among young adult African American vapers
一种神经影像学方法,可促进对年轻非洲裔美国电子烟使用者烟草使用升级风险的机制理解
  • 批准号:
    10629374
  • 财政年份:
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成人日间服务对非裔美国痴呆症家庭护理人员的社会心理和生理压力测量的影响
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    2021
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Voice-Activated Technology to Improve Mobility & Reduce Health Disparities: EngAGEing African American Older Adult-Care Partner Dyads
语音激活技术可提高移动性
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    10494191
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    2021
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Impact of Adult Day Services on Psychosocial and Physiological Measures of Stress among African American Dementia Family Caregivers
成人日间服务对非裔美国痴呆症家庭护理人员的社会心理和生理压力测量的影响
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  • 批准号:
    10654831
  • 财政年份:
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Development, Implementation, and Evaluation of a Smoking Cessation Intervention Tailored to Rural Young Adult African American Men: Toward Scalability
针对农村年轻非裔美国男性的戒烟干预措施的制定、实施和评估:走向可扩展性
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