Does Switching to Nicotine-containing Electronic Cigarettes Reduce Health Risk Markers?
改用含尼古丁的电子烟会减少健康风险标志吗?
基本信息
- 批准号:9752508
- 负责人:
- 金额:$ 76.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-15 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolAdultAwarenessBehavioralBiological MarkersBloodCarcinogensCardiovascular systemCigaretteCigarette SmokerCotinineDatabasesDependenceDevelopmentDevicesDoseDouble-Blind MethodElectrocardiogramElectronic cigaretteExhalationFree RadicalsFundingGlutathioneGoalsHealthHumanInfrastructureLipidsLiquid substanceLungMeasuresNicotineOutcomeOxidesParticipantPlacebosProcessPropylene GlycolsPulmonary function testsRandomizedResearchRespiratory SystemRiskRisk MarkerRoleScienceSmokerSmokingSmoking BehaviorSmoking and Health ResearchSolventsSourceStandardizationSurveysTelephoneTestingTobaccoTobacco useUnited StatesUnited States National Institutes of HealthWorkbehavior changecancer biomarkerscardiovascular effectscardiovascular risk factorcigarette smokingcohortcombustible cigarettedesignelectronic cigarette usefine particlesfollow-upformer smokerinnovationliquid nicotinenicotine inhalationnicotine vaporplacebo controlled studyrecruitrespiratorysmoking cessationvegetable glycerinvolunteer
项目摘要
Project Summary/Abstract
Over the past ten years, a new inhaled nicotine device, popularly referred to as an electronic cigarette (e-cig),
has become increasingly popular around the world, particularly in the United States where more than 79% of
US adults are currently aware of the devices and 3.7% are using one on a regular basis. Current e-cig use is
most prevalent among current smokers (15.9%) and recent ex-smokers (22.0%) and is very uncommon among
adult never cigarette smokers (0.4%). As the popularity of these devices has increased, the types of devices
and the associated products available to users have diversified, making it difficult for users and non-users alike
to understand the devices and their potential harms or benefits. E-cigarettes deliver high doses of fine particles
and highly oxidizing free radicals in the human respiratory system. Fine particles are emitted when the solvents
propylene glycol and vegetable glycerin, along with flavors, additives and nicotine are aerosolized, and
respiratory and cardiovascular effects have been documented, but adequate assessments are lacking. The
recent development of a Standardized Research E-Cig (SREC) with both medium (15 mg/ml) and placebo
(zero mg/ml) nicotine concentration in the liquid now offers the possibility of testing the likely health effects of
attempting to switch from cigarette smoking to an SREC and to examine the effects of nicotine in the liquid on
that process. Our long term goal is to understand the likely health effects of cigarette smokers switching to a
Standardized Research E-Cig (SREC) and to assess the role of nicotine delivery on switching, acceptability
and markers of health outcomes. The specific objective of this proposal is to recruit a cohort of 240 current
exclusive daily smokers and to measure a comprehensive battery of health markers at baseline and at 3 and 6
weeks after attempting to switch completely to SRECs containing either zero or 15 mg/ml nicotine in a
randomized double-blind, placebo-controlled design. The NIH-funded Penn State Tobacco Center of
Regulatory Science has conducted a number of preliminary studies of electronic cigarette use. These studies
have provided us with the infrastructure and expertise to conduct a study of health risks associated with
switching to a Standardized Research E-Cig, with the following three specific aims: AIM 1. To characterize the
short-term effects of attempting to switch from traditional cigarette smoking to a Standardized Research E-Cig
using a comprehensive battery of measures (e.g. carcinogen biomarker, NNAL, pulmonary function testing,
lipid panel, glutathione, exhaled CO, blood nicotine and cotinine, BP etc.) over 6 weeks. AIM 2. To compare
the effects of nicotine containing versus zero nicotine liquid on reduction of smoking behavior and health
markers. AIM 3. At the end of each participant's 6 week participation they will be provided with information
about the health effects of tobacco product use, how to purchase SREC supplies if they wish to continue using
and sources of assistance to quit smoking, and they will be asked to complete telephone and online survey 4
weeks later.
项目摘要/摘要
在过去的十年里,一种新的尼古丁吸入设备,通常被称为电子烟(e-cig),
在世界各地越来越受欢迎,特别是在美国,超过79%的
美国成年人目前知道这些设备,3.7%的人经常使用。目前电子烟的使用量为
在现在吸烟者(15.9%)和最近戒烟者(22.0%)中最常见,在
成人从不吸烟(0.4%)。随着这些设备的普及,设备的类型
而且用户可以使用的相关产品也变得多样化,这给用户和非用户带来了困难
了解这些设备及其潜在的危害或好处。电子烟会产生高剂量的细颗粒物
和人体呼吸系统中高度氧化的自由基。当溶剂释放出细小的颗粒时
丙二醇和蔬菜甘油以及香料、添加剂和尼古丁被雾化,以及
对呼吸和心血管的影响已有记录,但缺乏充分的评估。这个
含中浓度(15 mg/ml)和安慰剂的标准化研究电子免疫球蛋白(SREC)的研究进展
(0毫克/毫升)液体中的尼古丁浓度现在提供了测试可能的健康影响的可能性
尝试从吸烟转向SREC,并检查液体中尼古丁对
这一过程。我们的长期目标是了解吸烟者改用
标准化研究E-Cig(SREC)和评估尼古丁传递对转换、可接受性的作用
以及健康结果的标志物。这项建议的具体目标是招募一支240名现役军人
独家每日吸烟者,并在基线、3岁和6岁时测量一组全面的健康标志物
在尝试完全改用SREC后的几周内,SREC的尼古丁含量为0或15 mg/ml
随机、双盲、安慰剂对照设计。美国国立卫生研究院资助的宾夕法尼亚州立烟草中心
监管科学已经对电子烟的使用进行了一些初步研究。这些研究
为我们提供了基础设施和专业知识,以进行与以下相关的健康风险研究
转换到标准化的研究电子文明,有以下三个具体目标:目标1.描述
尝试从传统吸烟转向标准化研究电子烟的短期效果
使用一系列综合措施(例如致癌生物标记物、NNAL、肺功能测试、
血脂、谷胱甘肽、呼出一氧化碳、血尼古丁和可替宁、血压等)超过6周。目标2.比较
含尼古丁与不含尼古丁液体对减少吸烟行为和健康的影响
记号笔。目标3.在每个参与者的6周参与结束时,将向他们提供信息
关于使用烟草产品对健康的影响,如果他们希望继续使用,如何购买SREC用品
和戒烟的帮助来源,他们将被要求完成电话和在线调查4
几周后。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JONATHAN FOULDS其他文献
JONATHAN FOULDS的其他文献
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{{ truncateString('JONATHAN FOULDS', 18)}}的其他基金
Penn State TCORS: Tobacco Product Composition Effects on Toxicity and Addiction
宾夕法尼亚州立大学 TCORS:烟草产品成分对毒性和成瘾性的影响
- 批准号:
10665895 - 财政年份:2023
- 资助金额:
$ 76.06万 - 项目类别:
Project 3: Randomized Placebo-controlled Trial of Nicotine Pouches in Smokers
项目 3:吸烟者尼古丁袋的随机安慰剂对照试验
- 批准号:
10665898 - 财政年份:2023
- 资助金额:
$ 76.06万 - 项目类别:
Randomized trial of low nicotine cigarettes plus electronic cigarettes in smokers with a mental health condition
对有心理健康状况的吸烟者进行低尼古丁香烟加电子烟的随机试验
- 批准号:
10229461 - 财政年份:2019
- 资助金额:
$ 76.06万 - 项目类别:
Does Switching to Nicotine-containing Electronic Cigarettes Reduce Health Risk Markers?
改用含尼古丁的电子烟会减少健康风险标志吗?
- 批准号:
10294089 - 财政年份:2018
- 资助金额:
$ 76.06万 - 项目类别:
Random nicotine delivery: A novel intervention for smokers
随机尼古丁输送:针对吸烟者的新型干预措施
- 批准号:
8809791 - 财政年份:2014
- 资助金额:
$ 76.06万 - 项目类别:
Random nicotine delivery: A novel intervention for smokers
随机尼古丁输送:针对吸烟者的新型干预措施
- 批准号:
8925844 - 财政年份:2014
- 资助金额:
$ 76.06万 - 项目类别:
Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety p248-288
项目 2:减少情绪和焦虑吸烟者的尼古丁香烟 p248-288
- 批准号:
8737840 - 财政年份:2014
- 资助金额:
$ 76.06万 - 项目类别:
Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)
宾夕法尼亚州立大学烟草监管科学中心 (TCORS)
- 批准号:
8919320 - 财政年份:2013
- 资助金额:
$ 76.06万 - 项目类别:
Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)
宾夕法尼亚州立大学烟草监管科学中心 (TCORS)
- 批准号:
8582174 - 财政年份:2013
- 资助金额:
$ 76.06万 - 项目类别:
Project 2: Reduced Nicotine Cigarettes in Smokers with Mood and Anxiety p248-288
项目 2:减少情绪和焦虑吸烟者的尼古丁香烟 p248-288
- 批准号:
8594387 - 财政年份:2013
- 资助金额:
$ 76.06万 - 项目类别:
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