Pennsylvania State University Tobacco Center of Regulatory Science (TCORS)

描述(由申请人提供)：宾夕法尼亚州立烟草监管科学中心(TCORS)的总体目标是发展领先的最先进的研究和培训基础设施，为烟草产品监管政策提供信息。为了实现这些目标，PSTCORS正在将宾夕法尼亚州立医学院的资源与宾夕法尼亚州州立大学、哈佛大学和乔治华盛顿大学的大学园区主校区统一起来。宾夕法尼亚州立大学的许多设施将用于促进创新研究和培训，包括新建的吸烟实验室、核磁共振实验室，以及我们由NIH资助的临床和翻译科学研究所。TCORS将允许我们增加额外的专业知识，例如一个吸烟生物标记物核心实验室，该实验室将为所有TCORS进行烟草科学的专门分析。我们TCORS的一个中心主题是研究弱势群体(如低社会经济地位、精神障碍)和少数群体中的烟草监管科学。这将通过三个相辅相成的研究项目来实现，这些项目共享共同的方法、共同的核心多学科方法和共同的领导，总体目标是与烟草监管政策相关。宾夕法尼亚州立大学认识到卓越中心对烟草监管研究的普遍需求，并大力支持其研究和培训中的跨学科努力和多样性 和教育项目。这一承诺将通过为烟草法规学者制定专门的教育计划和试点项目计划来实现，该计划旨在促进测试和研究烟草危害的创新想法和研究方法。宾夕法尼亚州立大学世界校园将促进我们在烟草监管研究方面培训年轻科学家的努力，并与其他烟草管制研究机构合作。这些努力是为了在未来维持TCORS的概念。 相关性：香烟占美国消费的所有可燃烟草烟雾产品的90%，是导致可避免疾病的最重要原因。宾夕法尼亚州立大学TCORS将评估吸烟者从普通香烟转向减少尼古丁香烟对尼古丁依赖和烟草危害的健康影响。如果安全有效，这一战略将对公众健康产生巨大的好处。

DESCRIPTION (provided by applicant): The overall goal of the Penn State Tobacco Center of Regulatory Science (TCORS) is to develop a leading state-of-the-art research and training infrastructure that will inform policy on the regulation of tobacco products. To achieve these goals, the PSTCORS is uniting the resources of the Penn State College of Medicine with the main University Park campus in State College, PA, Harvard University and George Washington University. A number of Penn State's facilities will be utilized to foster innovative research and training including a newly built smoking laboratory, MRI labs, and our NIH-funded Clinical &Translational Science Institute. The TCORS will allow us to add additional expertise, such as a Smoking Biomarkers Core Laboratory that will perform specialized assays for tobacco science for all TCORS. A central theme of our TCORS is the study of tobacco regulatory science in vulnerable (e.g. low socioeconomic status, mental disorders) and minority populations. This will be accomplished through three complementary research projects that share common methodologies, common core multidisciplinary approaches, and common leadership with the overarching aim of relevancy for tobacco regulatory policies. Penn State University recognizes the more general needs of a Centers for Excellence for tobacco regulatory research in general and strongly supports interdisciplinary efforts and diversity in both its research and its training and educational programs. This commitment will be realized through the development of a dedicated educational program for tobacco regulation scholars and a pilot project program that fosters innovative ideas and research methods for testing and studying tobacco harm. The Penn State World Campus will facilitate our efforts in training young scientists in tobacco regulatory research and collaborating with other TCORS. These efforts are designed to sustain the TCORS concept in the future. RELEVANCE: Cigarettes constitute 90% of all combustible tobacco smoke products consumed in the United States and are the single most important cause of avoidable diseases. The Penn State TCORS will evaluate the health effects of switching smokers from their usual cigarettes to reduced nicotine cigarettes on nicotine dependence and tobacco harm. If safe and effective, this strategy will have large public health benefits.