Investigation of the molecular mechanisms underlying alpha synuclein function at the presynapse

突触前 α 突触核蛋白功能的分子机制研究

• 批准号: nhmrc : 1105478
• 负责人: Dr Sarah Gordon
• 金额: $ 28.91万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-molecular-mechanisms-function-presynapse/662834
• 关键词: Investigation; molecular; mechanisms; underlying; alpha

Parkinson’s Disease (PD) is a common brain disease affecting 7 million people worldwide. It is caused by the death of brain cells. ?-synuclein is a protein in that brain that is likely to contribute to the cell death in PD, but the normal role of the protein remains unknown. This study will investigate the function of ?-synuclein in maintaining normal healthy brain activity. In addition, this work will help us understand how normal brain processes are affected in diseases such as PD.

帕金森氏病(PD)是一种常见的脑部疾病，全球有700万人患病。它是由脑细胞死亡引起的。？-突触核蛋白是大脑中的一种蛋白质，可能导致帕金森病患者的细胞死亡，但该蛋白的正常作用尚不清楚。本研究将探讨？-突触核蛋白在维持正常健康脑活动中的作用。此外，这项工作将帮助我们了解正常的大脑过程是如何在帕金森氏症等疾病中受到影响的。