The functional interplay between alpha synuclein and synaptophysin in synaptic vesicle recycling

α突触核蛋白和突触素在突触小泡回收中的功能相互作用

• 批准号: nhmrc : 1085483
• 负责人: Dr Sarah Gordon
• 金额: $ 27.04万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-interplay-alpha-vesicle-recycling/519090
• 关键词: functional; interplay; between; alpha; synuclein

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, affecting 7 million people worldwide. ?-synuclein is a protein in that brain that is likely to contribute to the death of brain cells in PD, but the normal role of the protein remains unknown. This study will investigate the function of ?-synuclein in maintaining normal healthy brain activity. In addition, this work will help us understand the processes that go awry in neurodegenerative disease states such as PD.

帕金森病（PD）是第二大常见的神经退行性疾病，影响全球700万人。?-突触核蛋白是脑中一种蛋白质，其可能导致PD中脑细胞死亡，但该蛋白质的正常作用仍然未知。本研究将探讨？-突触核蛋白维持正常健康的大脑活动。此外，这项工作将帮助我们了解在神经退行性疾病状态（如PD）中出错的过程。