The Effects of Mood on Functional Brain Connectivity in Low Back Pain Patients du

情绪对腰痛患者大脑功能连接的影响

• 批准号: 8896433
• 负责人: Janelle E Letzen
• 金额: $ 3.92万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-13 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8896433
• 关键词: Address; Adult; Affective; Attention; Behavioral; Bilateral; Biological Neural Networks; Brain; Brain region; Clinical; Cognitive; Comorbidity; Complex; Control Groups; Critiques; Data; Data Collection; Development; Diagnosis; Disease; Esthesia; Functional Magnetic Resonance Imaging; Goals; Health; Heating; Individual; Knowledge; Low Back Pain; Measures; Medical; Meditation; Mental Depression; Moods; National Research Service Awards; Pain; Participant; Patients; Pattern; Perception; Pharmacological Treatment; Population; Process; Psychotherapy; Public Health; Quality of life; Relative (related person); Reporting; Research; Rest; Scanning; Sensory Process; Stimulus; Structure; Thalamic structure; Thinking; Work; chronic pain; cognitive task; daily functioning; experience; mental state; negative mood; neuromechanism; positive mood; psychologic; relating to nervous system; response; therapy development

DESCRIPTION (provided by applicant): The overall goal of this application is to further knowledge about the neural mechanisms of chronic pain. Recent studies have shown that patients with chronic pain have abnormal functional connectivity of the default mode network (DMN) [5,12, 14], a group of brain regions associated with freethinking, compared to healthy controls during resting-state. These group differences have been attributed to mechanisms of pain processing, however there are a number of potential confounds to this conclusion. Participants are typically instructed not to think about anything in particular, leading to unstandardized thought processes and, consequently, ambiguity in data interpretation. Few studies, however, have examined whether a participant's specific behavioral or cognitive state, such as mood or increased attention to clinical pain, contributes to this atypical connectivity. Because negative mood has been hypothesized to increase individuals' attention to somatic sensations [48], it is possible that there is a relationship between these neural processes in the experience of chronic pain. More research is needed to examine how these mental states influence brain activity during resting-state in the experience of chronic pain [8, 9, 10]. The proposed work will attempt to decompose the relationship between certain behavioral variables and brain activity during this paradigm. The Specific Aims of this NRSA are to 1) examine the effects of positive and pain-related negative mood on functional connectivity of the DMN and 2) examine the temporal relationship between pain-related attentional and affective neural processes during resting-state. With the findings from this research, we hope to provide useful information to the interpretation of resting-state data in chronic pain patients. Additionally, we hope to disentangle the temporal relationship of attentional and affective processes in the perception of clinical pain, which will help inform treatment development.

描述(由申请人提供)：本申请的总体目标是进一步了解慢性疼痛的神经机制。最近的研究表明，与健康对照组相比，慢性疼痛患者在静息状态下存在默认模式网络(DMN)[5，12，14]的功能连接异常，DMN是一组与自由思维相关的大脑区域。这些群体差异被归因于疼痛处理的机制，然而，这一结论存在一些潜在的混淆。参与者通常被指示不要去想任何特别的事情，这导致了非标准化的思维过程，从而导致了数据解释的模棱两可。然而，很少有研究研究参与者的特定行为或认知状态，如情绪或对临床疼痛的更多关注，是否有助于这种非典型的联系。由于负面情绪被假设为增加个体对躯体感觉的关注[48]，在慢性疼痛的体验中，这些神经过程之间可能存在联系。需要更多的研究来检验这些精神状态如何影响慢性疼痛体验中休息状态下的大脑活动[8，9，10]。这项拟议的工作将试图分解这一范式中某些行为变量和大脑活动之间的关系。本研究的具体目的是：1)研究积极情绪和疼痛相关的负面情绪对DMN功能连通性的影响；2)研究静息状态下疼痛相关的注意神经过程和情感神经过程之间的时间关系。通过本研究的发现，我们希望为解释慢性疼痛患者的静息状态数据提供有用的信息。此外，我们希望解开注意和情感过程在临床疼痛感知中的时间关系，这将有助于为治疗发展提供信息。