Advanced Multidisciplinary Training Program for Systems Biology

系统生物学高级多学科培训计划

• 批准号: 8867259
• 负责人: JAREK MELLER
• 金额: $ 16.69万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8867259
• 关键词: Systems Biology; Training Programs; multidisciplinary

DESCRIPTION (provided by applicant): In biomedical research fields, information now accumulates at a much faster rate than the paradigms and methods of classic research disciplines can effectively utilize. It is clear that discipline-specific expertise can no longer sustain adequate research progress. Emerging scientists, regardless of their breadth of training, must also be trained to work in research teams so that they can continually take advantage of new methods and concepts throughout their career. The proposed Advanced Multidisciplinary Training Program for Systems Biology is designed to prime researchers to tackle complex mechanisms of human disease utilizing cross- disciplinary approaches. There are two ways to cross disciplines. A multidisciplinary approach is team-building: experts from diverse disciplines applying their unique perspectives to address collectively a problem. In contrast, an interdisciplinary approach is when a single person applies knowledge that melds two or more traditional disciplines to solve a problem. New interdisciplinary fields (and investigators) have always been created by close multidisciplinary collaboration, and our program is designed to enforce such collaborations as an essential element of graduate training. Such comprehensive training requires a program specifically suited to the needs of individual trainees that also accelerates research progress. The overall goal of the Advanced Multidisciplinary Training Program for Systems Biology is to accelerate biomedical research through cross- discipline training of pre-doctoral students. The proposed Training Program will involve 33 program faculty members and selected pre-doctoral trainees matriculated into 14 degree-granting Ph.D. programs. Selected faculty members from these Ph.D. programs participate as mentors in this training program based on their diverse research backgrounds of relevance to this training program, and potential or existing collaborative research projects to provide students with interdisciplinary training opportunities. Our objectives are to provide didactic training in interdisciplinary approaches spanning computational to biological disciplines, and create a vibrant training environment for students that is a research community composed of multidisciplinary teams and interdisciplinary scientists working together to understand the mechanisms of human disease. The objectives will be achieved by implementation of a 2-year training plan that incorporates the following features: 1) didactic and experiential training in interdisciplinary research concepts and approaches, 2) a student- centered and flexible curriculum custom tailored to meet the needs of each student via computational and biology elective courses, 3) a research project that will require the student to use interdisciplinary approaches under the mentorship of a multi-disciplinary set of faculty co-mentors, and 4) students engaged in a community that encourages interaction between students and mentors through seminars, data and journal clubs, and an annual retreat. Plans for student and program assessment are designed to tightly track student progress, and allow for continual improvement of the training program.

描述（由申请人提供）：在生物医学研究领域中，现在的信息以比经典研究学科的范式和方法更快地积累的速度积累。显然，特定学科的专业知识无法再维持足够的研究进度。新兴的科学家，无论他们的培训广度如何，都必须接受培训以在研究团队中工作，以便他们可以在整个职业生涯中不断利用新的方法和概念。拟议的系统生物学的高级多学科培训计划旨在使用跨学科方法来解决人类疾病的复杂机制。有两种跨学科的方法。多学科的方法是团队建设：来自不同学科的专家，采用其独特的观点来共同解决问题。相反，跨学科的方法是一个人应用知识融合了两个或更多传统学科来解决问题的知识。新的跨学科领域（和调查人员）始终是由近距离学科的合作创建的，我们的计划旨在执行此类合作，以此作为研究生培训的基本要素。这样的全面培训需要一项专门适合各个学员需求的计划，这也加速了研究进度。先进的系统生物学多学科培训计划的总体目标是通过对博士前学生的跨学科培训来加速生物医学研究。拟议的培训计划将涉及33名课程教职员工，并选择入学的博士学位前学员入学到14度授予博士学位。程序。这些博士学位的选拔教职员工计划基于与该培训计划相关的多样化研究背景以及潜在或现有的协作研究项目，以为学生提供跨学科的培训机会。我们的目标是在跨学科的方法中提供教学培训，这些方法涵盖了生物学学科的计算，并为学生创造了一个充满活力的培训环境，这是一个由多学科团队和跨学科科学家组成的研究社区，共同努力了解人类疾病的机制。目标将通过实施为期两年的培训计划来实现以下特征：1）在跨学科研究概念和方法中进行教学和体验培训，2）量身定制的学生中心和灵活的课程，以满足每个学生通过计算和生物学课程的需求，以实现跨学科的跨学科方法，3）教职员工和4）学生参与了一个社区，该社区通过研讨会，数据和期刊俱乐部和年度撤退来鼓励学生与导师之间的互动。学生和计划评估的计划旨在严格跟踪学生的进步，并允许不断改进培训计划。

项目成果

Na,K-ATPase α2 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K+.

• DOI: 10.1085/jgp.201511407
• 发表时间: 2015-10
• 期刊: The Journal of general physiology
• 作者: DiFranco M;Hakimjavadi H;Lingrel JB;Heiny JA
• 通讯作者: Heiny JA

K⁺ and Rb⁺ Affinities of the Na,K-ATPase α₁ and α₂ Isozymes: An Application of ICP-MS for Quantification of Na⁺ Pump Kinetics in Myofibers.

• DOI: 10.3390/ijms19092725
• 发表时间: 2018-09-12
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Hakimjavadi H;Stiner CA;Radzyukevich TL;Lingrel JB;Norman N;Landero Figueroa JA;Heiny JA
• 通讯作者: Heiny JA