2015 Cerebellum GRC

 描述（由申请人提供）： 该提案寻求对第三届两年一度的戈登小脑研究会议（GRC）的部分支持，该会议将于2015年8月9日至14日在美国缅因州刘易斯顿的贝茨学院举行。最近开发了在电路和系统水平上研究神经系统功能的强大新方法，这些方法有望实现对大脑功能的深入，机械理解。这一前景在小脑中表现得最为明显。虽然小脑损伤最明显的症状是运动，但小脑的功能远不止产生运动。这可以从小脑功能障碍与运动障碍（包括共济失调、肌张力障碍和运动障碍）以及认知障碍的相关性中看出。小脑与阅读障碍、语言产生问题和自闭症谱系障碍等疾病的病因有关。小脑研究也开辟了新的领域，提供了一般的见解，如大脑发育，可塑性的细胞和分子机制，突触可塑性与学习，计算和计算方法的大脑功能。也许小脑研究对神经科学其他领域最重要的影响是说明了识别接线图和关注输入到输出转换的价值。从这些方面来说，保持小脑研究的最新进展对小脑研究者和那些对上述方法更感兴趣的人来说都是有价值的。尽管如此，对小脑感兴趣的人很少有机会见面，讨论他们的工作，了解新方法的发展和小脑病理学的新数据，并考虑对神经科学中更广泛问题的影响。小脑GRC的目的是提供一个场所，通过汇集来自多个职业阶段和不同背景的科学家来实现这些目标，为他们提供一个密切互动的机会，并发展科学关系，这将导致合作工作和新方法来调查小脑健康和疾病。 为实现这些目标，将在开幕之夜发表主旨演讲，然后在四天内由实地领导人和崭露头角的初级调查员进行八次口头介绍。会议的组织将提供充足的讨论时间，积极促进青年科学家和受训人员的参与，展示海报以最大限度地展示所有与会者的研究，并在科学会议之间提供非结构化的时间进行深入讨论。包括诸如小脑疾病，人类小脑功能，小脑处理的计算方法和小脑发育机制等会议不仅会产生健康的思想交流，而且还将教育研究人员他们的工作如何与神经和精神疾病的治疗有关。

 DESCRIPTION (provided by applicant): The proposal seeks partial support for the third biennial Gordon Research Conference (GRC) on the Cerebellum, to be held at Bates College in Lewiston, Maine, USA, August 9-14, 2015. Powerful new approaches for studying nervous system function at the circuit and systems level have recently been developed and these hold promise for achieving a deep, mechanistic understanding of brain functions. Nowhere is this promise more apparent than for the cerebellum. Although the most obvious symptoms of cerebellar damage are motor, cerebellar function is about much more than generating movements. This can be seen in the way cerebellar dysfunction is associated both with motor disorders (including ataxias, dystonia, and dyskinesia) and with cognitive impairments as well. The cerebellum is implicated in the etiologies of disorders such dyslexia, language production issues and autism spectrum disorder. Cerebellar research has also broken new ground by providing general insights in such areas as brain development, cellular and molecular mechanisms of plasticity, relating synaptic plasticity to learning, computation and computational approaches to brain function. Perhaps the most important influence of cerebellar research on the rest of neuroscience has been illustrating the value of identifying wiring diagrams and focusing interest on input to output transformations. In these ways, keeping up to date on cerebellar research is valuable for both cerebellar researchers and for those with more general interests in the approaches listed above. Despite this, there have been few opportunities for those interested in the cerebellum to meet, discuss their work, to be informed by developments in new methods and by new data on cerebellar pathologies, and to consider implications for broader questions in neuroscience. The aims of the Cerebellum GRC are to provide a venue to accomplish these goals by bringing together scientists from multiple career stages and different backgrounds, to provide them an opportunity to interact closely and to develop scientific relationships that will lead to collaborative work and new approaches to investigating the cerebellum in health and disease. These aims will be achieved by a keynote address on opening night followed by eight sessions of oral presentations over four days presented by leaders in the field and by up-and-coming junior investigators. The organization of the meeting will provide ample discussion time with active facilitation of participation by young scientists an trainees, poster presentations for maximal exposure of all attendees' research, and unstructured time between scientific sessions for in-depth discussions. Inclusion of such sessions as disorders of the cerebellum, human cerebellar function, computational approaches to cerebellar processing and mechanisms of cerebellar development will not only generate healthy exchange of ideas but will also educate investigators about how their work pertains to and can best be brought to bear on the treatment of neurological and mental disorders.