Safe Ultrasonic Transmission Lines for MRI Catheters
用于 MRI 导管的安全超声波传输线
基本信息
- 批准号:8879142
- 负责人:
- 金额:$ 18.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAirAneurysmAnimal ModelAnimalsArteriesAtherosclerosisBlood VesselsBlood flowCardiovascular systemCatheterizationCathetersChokingClinicalClinical TrialsCollaborationsComplexCoronary ArteriosclerosisCoupledCouplingDetectionDevice DesignsDevice SafetyDevicesDiagnostic radiologic examinationDistalEngineeringEnvironmentFiberFluoroscopyFrequenciesGoalsHealthHeatingHospitalizationImageImageryImaging DeviceIn VitroInterferometryInterventionIonizing radiationLasersLengthLocationMagnetic Resonance ImagingMeasurementMeasuresMechanicsMedical ImagingMetalsMethodsModelingMorphologic artifactsMotionNational Heart, Lung, and Blood InstituteOperative Surgical ProceduresOpticsPatientsPatternPerformancePerfusionPeripheralPhysiologicalProceduresRadiationRelative (related person)ResearchResearch PersonnelResourcesRiskRoentgen RaysRunningSchemeSignal TransductionSliceStructureTechniquesTemperatureTestingTherapeuticTimeTranslatingUltrasonic TransducerUltrasonic waveUltrasonicsUltrasonographyUnited States National Institutes of HealthUniversitiesbaseclinical applicationcongenital heart disordercost effectivedesigndetectorimage guidedimage guided interventionin vivoionizationmagnetic fieldminimally invasivenoveloperationoptical fiberoptical sensorpreclinical evaluationprototyperadio frequencyresearch clinical testingsafety testingsoft tissuetransmission process
项目摘要
DESCRIPTION (provided by applicant): Catheter based minimally invasive interventions are becoming a preferred method as compared to surgical procedures due to the reduction of operation time, patient discomfort, hospitalization time, and procedure related risks. While X-ray fluoroscopy is widely used as a imaging guidance for the minimally invasive procedures such as treatment of obstructive coronary artery disease, peripheral artery atherosclerosis and aneurysm, and structural or congenital heart disease, magnetic resonance imaging (MRI) can provide superior soft tissue contrast while eliminating the ionization radiation exposure on both patient and operator in these procedures. MRI also provides multi slice imaging and allows physiological measurements such as blood flow, temperature, perfusion and motion. A significant issue with MRI guided interventions is that most traditional interventional devices (catheters, guidewires etc.) either invisible or not suitable for use under MRI. Active receive-onl devices using small coils or dipole antennae on the catheter shaft to detect the RF signals for device location and/or orientation under MRI use long conductive transmission lines. These approaches are problematic as RF induced heating over long conductor components of the devices needs to be addressed before moving on clinical trials. Although promising improvements in terms of RF induced heating problem have been achieved by detuning, RF chokes or transformers, none of these techniques can offer active device design that can have clinically acceptable mechanical performance. In this application, we aim to develop a clinical-grade active catheter device that does not need long conductor transmission lines for active device visualization under MRI. The active catheter design incorporates a distal loop coil that is electrically connected to an ultrasonic transducer having a comparable profile. This ultrasonic transducer induces ultrasonic waves at the Larmor frequency at the distal end of a dielectric optical fiber that runs along the active catheter shaft. This optical fiber serves as the transmission line instead of a conductor, eliminating the RF induced heating. The strain generated by the ultrasound transducer will be measured using optical interferometry by coupling a laser at the proximal end of the optical fiber using the acousto-optical effect. A fiber
embedded Bragg reflector grating will be used for this purpose. The active devices will be designed, fabricated and incorporated into clinical grade catheter prototypes. The prototypes will be tested under MRI: in-vitro using specially prepared phantoms and in-vivo in large animals at NHLBI facilities.
描述(由申请人提供):与外科手术相比,基于导管的微创介入治疗由于减少了手术时间、患者不适、住院时间和手术相关风险而成为首选方法。虽然X射线透视被广泛用作微创手术的成像引导,例如阻塞性冠状动脉疾病、外周动脉粥样硬化和动脉瘤以及结构性或先天性心脏病的治疗,但磁共振成像(MRI)可以提供上级软组织对比度,同时消除这些手术中患者和操作者的电离辐射暴露。MRI还提供多切片成像,并允许生理测量,如血流、温度、灌注和运动。MRI引导介入的一个重要问题是,大多数传统的介入器械(导管、导丝等)或者不可见或者不适合在MRI下使用。在导管轴上使用小线圈或偶极天线以在MRI下检测用于器械位置和/或方向的RF信号的有源仅接收器械使用长导电传输线。这些方法存在问题,因为在进行临床试验之前,需要解决器械长导体组件上的RF感应加热问题。尽管通过失谐、RF扼流圈或变压器在RF感应加热问题方面取得了有希望的改善,但这些技术都无法提供具有临床可接受机械性能的有源器械设计。在本申请中,我们的目标是开发一种临床级有源导管器械,该器械不需要长导体传输线即可在MRI下实现有源器械可视化。有源导管设计包含远端环形线圈,其电连接到具有可比轮廓的超声换能器。该超声换能器在沿有源导管轴沿着延伸的介电光纤的远端处以拉莫尔频率感应超声波。该光纤用作传输线而不是导体,消除了RF感应加热。超声换能器产生的应变将使用光学干涉测量法通过使用声光效应在光纤近端耦合激光来测量。纤维
嵌入式布拉格反射器光栅将用于此目的。将设计、制造有源器械并将其纳入临床级导管原型。原型将在MRI下进行测试:使用专门制备的体模进行体外测试,并在NHLBI机构的大型动物中进行体内测试。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
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F. Levent Degertekin其他文献
Dynamically reconfigurable acoustofluidic metasurface for subwavelength particle manipulation and assembly
用于亚波长粒子操纵和组装的动态可重构声流体超表面
- DOI:
10.1038/s41467-024-55337-0 - 发表时间:
2025-01-15 - 期刊:
- 影响因子:15.700
- 作者:
Sushruta Surappa;Suraj Pavagada;Fernando Soto;Demir Akin;Charles Wei;F. Levent Degertekin;Utkan Demirci - 通讯作者:
Utkan Demirci
IVUS beyond the horizon.
IVUS 超出地平线。
- DOI:
10.4244/eijv2i1a23 - 发表时间:
2006 - 期刊:
- 影响因子:0
- 作者:
A. V. D. van der Steen;R. Baldewsing;F. Levent Degertekin;S. Emelianov;M. Frijlink;Yuji Furukawa;David E. Goertz;Mustafa Karaman;P. Khuri;Kang Kim;F. Mastik;T. Moriya;O. Oralkan;Y. Saijo;J. Schaar;P. Serruys;S. Sethuraman;A. Tanaka;H. Vos;Russell S Witte;Matthew O’Donnell - 通讯作者:
Matthew O’Donnell
Controlling tip-sample interaction forces during a single tap for improved topography and mechanical property imaging of soft materials by AFM.
在单次敲击过程中控制尖端与样品的相互作用力,以改善 AFM 对软材料的形貌和机械性能成像。
- DOI:
10.1016/j.ultramic.2009.04.006 - 发表时间:
2009 - 期刊:
- 影响因子:2.2
- 作者:
Z. Parlak;R. Hadizadeh;M. Balantekin;F. Levent Degertekin - 通讯作者:
F. Levent Degertekin
F. Levent Degertekin的其他文献
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{{ truncateString('F. Levent Degertekin', 18)}}的其他基金
Acousto-optical RF field sensors for safer diagnostic and interventional MRI
用于更安全的诊断和介入 MRI 的声光射频场传感器
- 批准号:
10526413 - 财政年份:2020
- 资助金额:
$ 18.34万 - 项目类别:
Acousto-optical RF field sensors for safer diagnostic and interventional MRI
用于更安全的诊断和介入 MRI 的声光射频场传感器
- 批准号:
10300995 - 财政年份:2020
- 资助金额:
$ 18.34万 - 项目类别:
Acousto-optical RF field sensors for safer diagnostic and interventional MRI
用于更安全的诊断和介入 MRI 的声光射频场传感器
- 批准号:
9917421 - 财政年份:2020
- 资助金额:
$ 18.34万 - 项目类别:
Acousto-optical RF field sensors for safer diagnostic and interventional MRI
用于更安全的诊断和介入 MRI 的声光射频场传感器
- 批准号:
10093044 - 财政年份:2020
- 资助金额:
$ 18.34万 - 项目类别:
Intravascular Ultrasound Imaging Guidewire with Wireless Readout
具有无线读数功能的血管内超声成像导丝
- 批准号:
8702711 - 财政年份:2014
- 资助金额:
$ 18.34万 - 项目类别:
MRI-safe 3Dl intracardiac ultrasound catheter for cardiovascular intervention
用于心血管介入的 MRI 安全 3Dl 心内超声导管
- 批准号:
8639877 - 财政年份:2014
- 资助金额:
$ 18.34万 - 项目类别:
Safe Ultrasonic Transmission Lines for MRI Catheters
用于 MRI 导管的安全超声波传输线
- 批准号:
8772802 - 财政年份:2014
- 资助金额:
$ 18.34万 - 项目类别:
Gap Feedback Linearization of CMUTs for Harmonic Imaging and HIFU
用于谐波成像和 HIFU 的 CMUT 间隙反馈线性化
- 批准号:
8656105 - 财政年份:2013
- 资助金额:
$ 18.34万 - 项目类别:
Gap Feedback Linearization of CMUTs for Harmonic Imaging and HIFU
用于谐波成像和 HIFU 的 CMUT 间隙反馈线性化
- 批准号:
8512365 - 财政年份:2013
- 资助金额:
$ 18.34万 - 项目类别:
Fully Integrated Single Chip CMUT Arrays for Forward Looking IVUS and ICE
用于前瞻性 IVUS 和 ICE 的完全集成单芯片 CMUT 阵列
- 批准号:
7987184 - 财政年份:2010
- 资助金额:
$ 18.34万 - 项目类别:
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