Long-term Prevention of Peri-Implantitis via Nano-textured, TiO/Ag Surfaces

通过纳米纹理 TiO/Ag 表面长期预防种植体周围炎

• 批准号: 8979247
• 负责人: JASON E BURNS
• 金额: $ 22.5万
• 依托单位: N2 BIOMEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8979247
• 关键词: Address; Affect; Anti-Bacterial Agents; Automobile Driving; Bacteria; Benchmarking; Biocompatible Coated Materials; Biological Assay; Cell-Matrix Junction; Cells; Control Groups; Dental Implants; Deposition; Disease; Fibroblasts; Film; Gingiva; Goals; Growth; Implant; In Vitro; Ions; Life; Modification; Morphology; Osseointegration; Osteoblasts; Phase; Prevention; Property; Research; Sampling; Silver; Structure; Surface; Testing; Thick; Time; Tissues; Titania; Titanium; Work; antimicrobial; base; bone; bone loss; design; implantation; nano; nanoscale; nanostructured; pathogenic bacteria; peri-implantitis; predictive modeling; programs; public health relevance; seal; success; titanium dioxide

 DESCRIPTION (provided by applicant): Peri-implantitis is a disease characterized by progressive loss of bone surrounding dental implants which may occur many years after successful implantation. In this program a dual mode surface treatment will be developed that will encourage a strong interface between the implant and living bone and gingival tissue while also providing a long lasting anti-bacterial effect to discourage the bacterial precursors to peri- implantitis. To achieve this goal two complementary surface modifications will be applied. A nano-textured surface will be developed based on predictive modeling in which anti-bacterial, pro-osteoblast, and pro-gingival fibroblast properties will be selected. The textured coating material will be an amorphous, silver-doped titania, deposited by ion beam assisted deposition. This coating will bond aggressively to the Ti implant surface, and itself provide significant, and very long lasting antimicrobial efficacy. Efficacy will be demonstrated through combination perio-pathogenic bacteria, osteoblast, and gingival fibroblast cell assays This combination of morphologic and material approaches will promote osseointegration and a healthy mucosal seal, while also providing very long lasting antimicrobial protection that will significantly reduc the occurrence of peri-implantitis associated with dental implants.

 描述(申请人提供)：种植体周围炎是一种以牙种植体周围骨进行性丢失为特征的疾病，可能在种植成功多年后发生。在这个项目中，将开发一种双重模式的表面处理，该表面处理将鼓励种植体与活骨和牙龈组织之间形成牢固的界面，同时还提供持久的抗菌效果，以阻止细菌前体进入牙周。 种植炎。为了实现这一目标，将应用两种互补的表面修饰。纳米质地的表面将开发基于预测建模，其中抗菌，成骨细胞，和牙龈成纤维细胞的性质将被选择。织构涂层材料将是非晶态的掺银二氧化钛，通过离子束辅助沉积。这种涂层将积极地结合到钛种植体表面，本身就提供了显著的、非常持久的抗菌效果。通过对牙周病原菌、成骨细胞和牙龈成纤维细胞的联合检测将证明其有效性。这种形态和材料方法的结合将促进骨整合和健康的粘膜封闭，同时还提供非常持久的抗菌保护，从而显著减少与种植体相关的种植周炎的发生。

项目成果

Decreased bacterial growth on titanium nanoscale topographies created by ion beam assisted evaporation.

• DOI: 10.2147/ijn.s119750
• 发表时间: 2017
• 期刊: International journal of nanomedicine
• 影响因子: 8
• 作者: Stolzoff M;Burns JE;Aslani A;Tobin EJ;Nguyen C;De La Torre N;Golshan NH;Ziemer KS;Webster TJ
• 通讯作者: Webster TJ