Long-term Prevention of Peri-Implantitis via Nano-textured, TiO/Ag Surfaces

 描述（由申请人提供）：种植体周围炎是一种疾病，其特征是牙种植体周围的骨进行性丢失，可能在成功植入多年后发生。在该项目中，将开发一种双模式表面处理，该处理将促进种植体与活骨和牙龈组织之间的牢固界面，同时还提供持久的抗菌效果，以阻止细菌前体侵入。 种植体炎为了实现这一目标，将应用两种互补的表面改性。纳米纹理表面将根据预测建模开发，其中将选择抗菌，促成骨细胞和促牙龈成纤维细胞特性。纹理化涂层材料将是通过离子束辅助沉积而沉积的无定形银掺杂的二氧化钛。该涂层将积极结合到钛植入物表面，并且本身提供显著且非常持久的抗菌功效。将通过结合牙周致病菌、成骨细胞和牙龈成纤维细胞测定来证明疗效。这种形态学和材料方法的组合将促进骨整合和健康的粘膜密封，同时还提供非常持久的抗菌保护，这将显著减少与牙科种植体相关的种植体周围炎的发生。

 DESCRIPTION (provided by applicant): Peri-implantitis is a disease characterized by progressive loss of bone surrounding dental implants which may occur many years after successful implantation. In this program a dual mode surface treatment will be developed that will encourage a strong interface between the implant and living bone and gingival tissue while also providing a long lasting anti-bacterial effect to discourage the bacterial precursors to peri- implantitis. To achieve this goal two complementary surface modifications will be applied. A nano-textured surface will be developed based on predictive modeling in which anti-bacterial, pro-osteoblast, and pro-gingival fibroblast properties will be selected. The textured coating material will be an amorphous, silver-doped titania, deposited by ion beam assisted deposition. This coating will bond aggressively to the Ti implant surface, and itself provide significant, and very long lasting antimicrobial efficacy. Efficacy will be demonstrated through combination perio-pathogenic bacteria, osteoblast, and gingival fibroblast cell assays This combination of morphologic and material approaches will promote osseointegration and a healthy mucosal seal, while also providing very long lasting antimicrobial protection that will significantly reduc the occurrence of peri-implantitis associated with dental implants.