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Paternal Brain Responses to Infant Face Cues: Effects of Intranasal Oxytocin

父亲大脑对婴儿面部线索的反应：鼻内催产素的作用

基本信息

批准号：
8899978
负责人：
Robin P. Kochel
金额：
$ 7.05万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8899978
关键词：
Address Affect Affective Amygdaloid structure Behavior Biological Brain Brain scan Caregivers Caring Child Child Development Child Rearing Cognitive Corpus striatum structure Cross-Over Studies Cues Data Dopamine Dorsal Emotions Employment Enrollment Ensure Face Facial Expression Fathers Female Functional Magnetic Resonance Imaging Funding Grant Home environment Homologous Gene Hormones Human Individual Infant Infant Behavior Inferior frontal gyrus Intervention Life MRI Scans Maternal Behavior Measures Medial Midbrain structure Mothers Neurobiology Neuropeptides Neurosecretory Systems Oxytocin Parents Paternal Behavior Pathway interactions Pattern Placebo Control Placebos Play Prefrontal Cortex Procedures Process Prosencephalon Randomized Research Rewards Rodent Role Sensory Sex Characteristics Shapes Social Behavior Social Development Specific qualifier value Substantia nigra structure Temporal Lobe Time United States Vasopressins Ventral Striatum Ventral Tegmental Area Videotape affection behavioral response brain circuitry caregiving cognitive development father role indexing interest male neglect neurobehavioral neuroimaging public health relevance relating to nervous system response reward processing sex social

项目摘要

DESCRIPTION (provided by applicant): In the United States today, one in three children live in homes without the presence of their biological father. In contrast, fathers are the primary caregivers for a small but increasing number of children, as more mothers return to full-time employment. Although there is substantial evidence for the importance and unique role of fathers in shaping child social and cognitive development, few studies have directly addressed the neural underpinnings of paternal caregiving or sex differences in parenting. Rodent and more recent human research has demonstrated the importance of the neuropeptide, oxytocin, in facilitating social and parenting behaviors. The aim of this R03 application is to examine sex differences in parental brain and behavioral responses to infant cues, by measuring the effect of intranasal oxytocin on 1) fathers' neural responses using functional MRI (fMRI), and 2) interactive behavior during a free play procedure. This will be compared with data from our currently funded R01 study: "Intranasal Oxytocin: A Neuropharmacological Intervention for Maternal Neglect?". Thirty first-time fathers will be enrolled, alongside their female partner and infant (from the concurrent R01 grant) in a randomized, placebo-controlled crossover study of intranasal oxytocin. FMRI brain responses to infant face cues will be measured, as well as videotaped behavioral responses of fathers during a free-play interaction procedure, the CARE-Index. It is hypothesized that fathers, compared with mothers, will show less activation of mesocorticolimbic dopamine reward circuits, including the amygdala, the ventral striatum (VS) and the ventromedial prefrontal cortex (vmPFC), when viewing their own vs. unknown infant faces during fMRI scanning. However, fathers will show greater activation of social-cognitive nigrostriatal dopamine circuits, including the dorsal striatum (DS) and the dorsolateral prefrontal cortex (dlPFC). Furthermore, it is hypothesized that intranasal oxytocin will diminish social-cognitive circuits in fathers, while enhancing affect-related brain circuitry. Finally, it is hypothesized that during the free play parent-infant interaction procedure (CARE-Index), fathers will score higher than mothers on cognitive measures (e.g. turn- taking contingencies and control) but lower on affective measures of parental sensitivity (e.g. facial and verbal expression, affection), with affective measures enhanced in fathers after intranasal oxytocin. Mothers will show a similar but less pronounced brain and behavioral response to oxytocin, reflected in a treatment x sex interaction effect. Regardless of sex, overall parental sensitivity (which incorporates both cognitive and affective measures) will be positively correlated with functional connectivity patterns between the amygdala, striatum and PFC. We anticipate that these results will help us to better understand how fathers respond to infant face cues, and elucidate sex differences in parental neuroendocrine functioning. This will provide preliminary data for an R01 application that will more fully examine paternal behavior, attachment and neuroimaging responses to intranasal oxytocin and its homologue, vasopressin.