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Integrative Health Sciences Facility Core

综合健康科学设施核心

基本信息

批准号：
8841117
负责人：
Reynold Alexander Panettieri
金额：
$ 28万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-13 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8841117
关键词：
Address Affinity Animals Asbestos Back Biological Biological Markers Biometry Case-Control Studies Cells Clinical Clinical Data Clinical Trials Clinical Trials Design Collection Communication Communities Community Outreach Core Facility Data Data Set Diesel Exhaust Enrollment Ensure Environmental Exposure Environmental Health Environmental Medicine Feasibility Studies Fostering Genetic Services Genomics Goals Government Health Health Professional Health Sciences Healthcare Human Human Resources In Vitro Individual Informatics Investigation Laboratories Link Longitudinal Studies Methods Modeling Molecular Oils Outcome Ozone Particulate Patients Performance Phenotype Pilot Projects Population Process Public Health Quality of life Randomized Recording of previous events Research Research Design Research Personnel Research Subjects Resolution Resources Risk Assessment Safety Sampling Seafood Services Specimen Specimen Handling Statistical Study Sulfur Dioxide Testing Transcend Translating Translational Research Vision Vulnerable Populations abstracting authority base biobank cohort community based participatory research community organizations data management environmental toxicology exposed human population fundamental research gene environment interaction genome wide association study human subject innovation member non-genomic novel diagnostics novel therapeutics population based pre-clinical quality assurance tool virtual

项目摘要

Integrative Health Sciences Facility Core (IHSFC) Abstract The IHSFC supports all human research in the CEET. It is the entity that permits the CEET to attain its Strategic Vision to perform translational environmental health research that will impact patients, communities, and the public. It provides highly focused transdisciplinary services including study design, enrollment of subjects, data management, access to biological samples, biostatistical analyses, interpretation of results and dissemination of results to the public through the Community Outreach and Engagement Core (COEC). Over the past four years, the IHSFC has uniquely focused on delivery of five specific services that include: human studies design and performance services, human exposure laboratories, human population exposure services, CEET virtual biorepositories, and biostatistics support for both non-genomics and genomics studies. Each service provides CEET investigators with unique tools to translate fundamental research into improvements in individual human and population-based cohorts to advance PREcision Environmental Medicine (PREEM). In a bi-directional manner, the IHSFC communicates with the COEC to formulate community-based questions and concerns into specific hypotheses for investigators with expertise in population-based studies. An important goal of the IHSFC is to promote inter-Environmental Health Science Core Center (EHS CC) collaborative projects in human subjects. Over the past four years, five interactive projects involving inter-EHS CC pilot projects or R01 equivalents have been initiated. The interaction of the IHSFC with other centers greatly extends the expertise to a network of EHS CCs to address inter-center human research. As described in the Strategic Vision, the IHSFC supports integrated research themes in humans that transcend affinity groups and the formation of translational research teams that involve CEET investigators and COEC members to address community-based questions.

综合健康科学设施核心（IHSFC）摘要 IHSFC支持CEET的所有人类研究。它是使CEET能够实现其战略目标的实体。愿景是进行转化环境健康研究，这将影响患者，社区和公众。它提供高度集中的跨学科服务，包括研究设计，受试者招募，数据管理、获取生物样本、生物统计分析、结果解释和通过社区外展和参与核心（COEC）向公众公布结果。在过去的四年里， IHSFC专注于提供五项具体服务，包括：人类研究设计和性能服务，人体暴露实验室，人群暴露服务，CEET虚拟生物储存库和生物统计学支持非基因组学和基因组学研究。每项服务提供 CEET研究人员拥有独特的工具，可以将基础研究转化为个人的改善，以人口为基础的队列，以推进PRECISE环境医学（PREEM）。以双向方式， IHSFC与COEC沟通，将基于社区的问题和关切制定为具体的为具有人群研究专业知识的研究者提供假设。IHSFC的一个重要目标是促进跨环境健康科学核心中心（EHS CC）在人类受试者的合作项目。超过在过去的四年里，五个涉及跨EHS CC试点项目或R01等效项目的互动项目，启动。IHSFC与其他中心的互动极大地扩展了EHS CC网络的专业知识，解决中心间人类研究问题。正如战略愿景所述，IHSFC支持综合研究超越亲和群体的人类主题和涉及翻译研究团队的形成 CEET调查人员和COEC成员解决基于社区的问题。