研究 R213G SOD3 多态性在肺部疾病中的作用-猫眼课题宝

研究 R213G SOD3 多态性在肺部疾病中的作用

批准号：

8848108

负责人：

RUSSELL Paul BOWLER

金额：

$28.1万

依托单位：

NATIONAL JEWISH HEALTH

依托单位国家：

美国

项目类别：

财政年份：

2012

资助国家：

美国

项目状态：

已结题

起止时间：

2012-07-01 至 2017-04-30

来源：

https://reporter.nih.gov/project-details/8848108

关键词：

Acute Affect Amino Acids Animal Model Antioxidants Apoptotic Arginine Attenuated Base Pairing Binding Biological Assay Breathing Candidate Disease Gene Cardiovascular Diseases Cause of Death Cells Chronic Obstructive Airway Disease Cigarette Code Confocal Microscopy Cytosine Data Development Diagnostic tests Elements Epithelial Epithelium Excision Extracellular Fluid Extracellular Matrix Extracellular Space Gene Proteins Genes Genetic Polymorphism Genetic Predisposition to Disease Genetic study Glycine Goals Guanine Hereditary Disease Heritability Human Human Genetics In Vitro Inflammation Injury Knock-in Mouse Knock-out Knockout Mice Knowledge Laboratories Lead Length of Stay Lipopolysaccharides Liquid substance Lung Lung diseases Macrophage Activation Mass Spectrum Analysis Methods Mus Myocardial Infarction Nitric Oxide Observational Study Organ Oxidants Oxidative Stress Plasma Population Predisposition Protein Binding Proteins Pulmonary Emphysema Pulmonary Function Test/Forced Expiratory Volume 1 Reporting Resolution Resources Respiratory physiology Risk Risk Factors Role Signal Pathway Single Nucleotide Polymorphism Smoke Smoker Smoking Stroke Structure of parenchyma of lung Superoxide Dismutase Testing Time Tissues Tobacco smoke Toxin United States Untranslated RNA Variant Western Blotting antioxidant therapy biobank cigarette smoking cytokine experience extracellular genetic variant human DNA in vivo lung injury macrophage novel diagnostics overexpression prevent protein distribution protein function research study response

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英文摘要

The rs1799895 single nucleotide polymorphism (SNP) is a non-synonymous base pair change in SOD3 that results in an arginine-to-glycine substitution (R213G) in extracellular superoxide dismutase protein (EC-SOD). This region is responsible for EC- SODs binding to extracellular matrix increases plasma levels 10-fold. The R213G SNP protects smokers from developing chronic obstructive pulmonary disease (COPD) and acute exacerbations of COPD. The goal of this proposal is to elucidate the mechanism by which the R213G protects the lung from tobacco smoke. To accomplish this aim, we have created a knock-in mouse with the identical SNP. Our methods will utilize more than a decade of experience studying the EC-SOD gene and COPD.

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会议论文

Murine extracellular superoxide dismutase is converted into the inactive fold by the Ser195Cys mutation.

小鼠细胞外超氧化物歧化酶通过 Ser195Cys 突变转化为失活折叠。

DOI： 10.1021/bi400171b

发表时间： 2013

期刊：

Biochemistry

影响因子： 2.9

作者：

[Scavenius,Carsten, Petersen,JaneS, Thomsen,LineR, Poulsen,EbbeToftgaard, Valnickova-Hansen,Zuzana, Bowler,RussellP, Oury,TimD, Petersen,SteenV, Enghild,JanJ]

通讯作者： Enghild,JanJ