Models, signals, and distributed bio-behavioral control of exercise in diabetes

糖尿病运动的模型、信号和分布式生物行为控制

基本信息

  • 批准号:
    8971447
  • 负责人:
  • 金额:
    $ 297.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-08-01 至 2020-05-31
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Physically active patients with type 1 diabetes (T1D) face a very specific challenge in their management of glycaemia: physical activity can dramatically alter glucose homeostasis both acutely and over a period of several hours. The magnitude of this behaviorally triggered physiological disturbance is highly variable and depends on a number of factors such as insulin- on-board, prandial state, and fitness to name only a few. These complex interactions and associated fear of hypoglycemia often lead to avoidance of physical activity. We propose to address this specific hurdle of living with diabetes by empowering patients through a network of medical devices, assembled into an adaptive artificial pancreas (AP) platform, tailored to the needs and choices of each patient. This project unites two leading groups in artificial pancreas development, the University of Virginia Center for Diabetes Technology and the Illinois Institute of Technology Center for Diabetes Research and Education. We propose to leverage our extensive technology portfolio in AP platform, closed loop algorithms, exercise detection and quantification, and modelling to address the following specific aims: 1. Patient-specific exercise risk alert system informing patients at the onset of exercise of likely hypoglycemia based on: (i) tuning a risk detector to each patient using DiAs cloud functionalities, and (ii) personalized simulation-based advice on treatment adaptation. 2. Exercise-informed automated insulin dosing: Upgrade to AP control system using exercise sensing to track metabolic risk and adjust insulin to maintain safe BG levels. 3. Fully-integrated Exercise-adapted AP system: We hypothesize that an exercise-informed AP system with both feed-forward (1) and feedback (2) components, freeing the patient from obligatory additional devices will improve glycemic safety and technology acceptance. We will demonstrate feasibility, safety, and efficacy of each of the proposed modules, independently and in concert, through three human clinical trials: two short term inpatient demonstration trials and one final longer term (4 months) home trial. This final trial will also explore psychosocial aspects of exercising with our platform, and start addressing key aspects of safety, accounting for adherence and technology acceptance of such a complex system. We expect the proposed system to enhance the safety and efficacy of AP in real life conditions. By creating a novel data infrastructure and optimal exercise control algorithms, this project has also the potential to generate clinically relevant derivatives for other mode of treatment.


项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
Automatically accounting for physical activity in insulin dosing for type 1 diabetes.
In Silico Analysis of an Exercise-Safe Artificial Pancreas With Multistage Model Predictive Control and Insulin Safety System.
  • DOI:
    10.1177/1932296819879084
  • 发表时间:
    2019-11-01
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Garcia-Tirado, Jose;Colmegna, Patricio;Breton, Marc D
  • 通讯作者:
    Breton, Marc D
Improving Glucose Prediction Accuracy in Physically Active Adolescents With Type 1 Diabetes.
Safety and Feasibility Evaluation of Step Count Informed Meal Boluses in Type 1 Diabetes: A Pilot Study.
1 型糖尿病中步数知情膳食推注的安全性和可行性评估:一项试点研究。
  • DOI:
    10.1177/1932296821997917
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Ozaslan,Basak;Brown,SueA;Pinnata,Jennifer;Barnett,CharlotteL;Carr,Kelly;Wakeman,ChristianA;Clancy-Oliveri,Mary;Breton,MarcD
  • 通讯作者:
    Breton,MarcD
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MARC D BRETON其他文献

MARC D BRETON的其他文献

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{{ truncateString('MARC D BRETON', 18)}}的其他基金

Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
  • 批准号:
    10676903
  • 财政年份:
    2021
  • 资助金额:
    $ 297.99万
  • 项目类别:
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
  • 批准号:
    10276560
  • 财政年份:
    2021
  • 资助金额:
    $ 297.99万
  • 项目类别:
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
  • 批准号:
    10488207
  • 财政年份:
    2021
  • 资助金额:
    $ 297.99万
  • 项目类别:
Translation of the UVA Advanced Automated Insulin Delivery Systems to Clinical Care in Young Children: Glycemic Control, Regulatory Acceptance and Optimization of Day to Day Use
UVA 先进自动胰岛素输送系统在幼儿临床护理中的应用:血糖控制、监管接受和日常使用优化
  • 批准号:
    10474818
  • 财政年份:
    2021
  • 资助金额:
    $ 297.99万
  • 项目类别:
Artificial Pancreas - Adolescent Physiology and Psychology Longitudinal Evaluation (A.P. APPLE)
人工胰腺 - 青少年生理学和心理学纵向评估 (A.P. APPLE)
  • 批准号:
    10381710
  • 财政年份:
    2020
  • 资助金额:
    $ 297.99万
  • 项目类别:
Translation of the UVA Advanced Automated Insulin Delivery Systems to Clinical Care in Young Children: Glycemic Control, Regulatory Acceptance and Optimization of Day to Day Use
UVA 先进自动胰岛素输送系统在幼儿临床护理中的应用:血糖控制、监管接受和日常使用优化
  • 批准号:
    10265602
  • 财政年份:
    2020
  • 资助金额:
    $ 297.99万
  • 项目类别:
Translation of the UVA Advanced Automated Insulin Delivery Systems to Clinical Care in Young Children: Glycemic Control, Regulatory Acceptance and Optimization of Day to Day Use
UVA 先进自动胰岛素输送系统在幼儿临床护理中的应用:血糖控制、监管接受和日常使用优化
  • 批准号:
    10470808
  • 财政年份:
    2020
  • 资助金额:
    $ 297.99万
  • 项目类别:
Artificial Pancreas - Adolescent Physiology and Psychology Longitudinal Evaluation (A.P. APPLE)
人工胰腺 - 青少年生理学和心理学纵向评估 (A.P. APPLE)
  • 批准号:
    10597623
  • 财政年份:
    2020
  • 资助金额:
    $ 297.99万
  • 项目类别:
HYPOGLYCEMIA PREVENTION AFTER EXERCISE IN ADOLESCENT T1DM
青少年 T1DM 运动后低血糖的预防
  • 批准号:
    8167207
  • 财政年份:
    2010
  • 资助金额:
    $ 297.99万
  • 项目类别:
FEASIBILITY STUDY OF A MODULAR CONTROL TO RANGE SYSTEM IN T1DM
T1DM 测距系统模块化控制的可行性研究
  • 批准号:
    8167201
  • 财政年份:
    2010
  • 资助金额:
    $ 297.99万
  • 项目类别:

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