Artificial Pancreas - Adolescent Physiology and Psychology Longitudinal Evaluation (A.P. APPLE)

人工胰腺 - 青少年生理学和心理学纵向评估 (A.P. APPLE)

基本信息

  • 批准号:
    10597623
  • 负责人:
  • 金额:
    $ 61.65万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-04-01 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

SUMMARY / ABSTRACT This project addresses what is perhaps the biggest challenge in the clinical care of Type 1 diabetes (T1D): the incredible rise in HbA1c levels seen during the adolescent age span of 11-15 years. This rise appears to be driven by physiologic changes (an increase in insulin resistance) that are not adequately addressed, in part because of psychosocial challenges (including family conflict, peer influence, and diabetes distress). We propose to follow adolescents longitudinally for two years, with assessment of these physiologic factors and exploratory aim following psychosocial factors, as well as testing a promising intervention in the artificial pancreas (AP). This study is titled A.P. APPLE for Artificial Pancreas Adolescent Physiology and Psychosocial Longitudinal Evaluation. We hypothesize that long-term use of an AP system (Tandem's Control-IQ, compared to Usual Care+CGM) will in part blunt the rise in HbA1c that is typically seen. However, even apart from testing this intervention, this project offers valuable observational data on the natural history of changes seen in participants in the control group. We will follow changes in insulin resistance by body compartment (liver vs. muscle/adipose tissue) during pubertal progression using stable-isotope triple-tracer mixed meal tests, revealing novel information about how puberty-related insulin resistance evolves over time by body compartment—as well as how the AP might respond to these changes. We will also follow key psychosocial processes of family conflict, peer influence, diabetes distress, depression and quality of life to evaluate their temporal relationships to sub- optimal control. Following these processes may help in the application of pharmacologic or psychologic approaches to improve adolescent control—either with or without AP use. Finally, we will follow modern markers of T1D control, including time-in-range and glycemic variability to document for providers how these factors change during pubertal progression and how they are related to physiologic and psychosocial changes. This study takes advantage of the University of Virginia Center for Diabetes Technology as an environment with expertise in each of the domains of glycemia, physiology and psychosocial factors—as well as development of an AP system that is effective in short-term trials at reducing HbA1c. The sub-optimal control during adolescence has gotten more pronounced in recent studies and contributes to long-term complications. This project will provide valuable clues about the durability of AP use among adolescents as well the contribution of rising insulin resistance and psychosocial barriers—with a long-term goal of improving control and long-term health of adolescents with T1D.
摘要/摘要 该项目解决了 1 型糖尿病 (T1D) 临床护理中可能面临的最大挑战: 在 11 至 15 岁的青少年时期,糖化血红蛋白 (HbA1c) 水平令人难以置信地上升。这次上涨似乎是 部分由未得到充分解决的生理变化(胰岛素抵抗增加)驱动 由于心理社会挑战(包括家庭冲突、同伴影响和糖尿病困扰)。我们 建议对青少年进行为期两年的纵向跟踪,评估这些生理因素和 遵循心理社会因素的探索性目标,以及测试人工干预的有前途的干预措施 胰腺(AP)。这项研究的标题是 A.P. APPLE for Artificial Pancreas Adolescent Physiology and Psychosocial 纵向评估。 我们假设长期使用 AP 系统(Tandem 的 Control-IQ,与 Usual Care+CGM 相比) 会在一定程度上抑制通常出现的 HbA1c 升高。然而,即使除了测试这种干预之外, 项目提供了有关控制参与者所见变化的自然历史的有价值的观察数据 团体。我们将跟踪身体部位(肝脏与肌肉/脂肪组织)的胰岛素抵抗变化 在青春期进展期间使用稳定同位素三重示踪剂混合膳食测试揭示新信息 关于青春期相关的胰岛素抵抗如何通过身体部位随时间演变,以及 AP 如何 可能会对这些变化做出反应。我们还将跟踪家庭冲突、同伴冲突等关键社会心理过程。 影响、糖尿病困扰、抑郁和生活质量,以评估其与亚健康的时间关系 最优控制。遵循这些过程可能有助于药理学或心理学的应用 改善青少年控制力的方法——无论是否使用 AP。最后,我们将遵循现代 T1D 控制标志物,包括时间范围和血糖变异性,以便为提供者记录这些 青春期进展过程中因素的变化以及它们与生理和心理变化的关系。 本研究利用弗吉尼亚大学糖尿病技术中心作为环境 拥有血糖、生理学和心理社会因素各个领域的专业知识,以及 开发可在短期试验中有效降低 HbA1c 的 AP 系统。 在最近的研究中,青春期的次优控制变得更加明显,并导致 长期并发症。该项目将为了解 AP 使用的持久性提供有价值的线索 青少年以及不断上升的胰岛素抵抗和社会心理障碍的影响——长期来看 改善 T1D 青少年的控制和长期健康的目标。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MARC D BRETON其他文献

MARC D BRETON的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MARC D BRETON', 18)}}的其他基金

Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
  • 批准号:
    10676903
  • 财政年份:
    2021
  • 资助金额:
    $ 61.65万
  • 项目类别:
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
  • 批准号:
    10276560
  • 财政年份:
    2021
  • 资助金额:
    $ 61.65万
  • 项目类别:
Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus
先进的人工胰腺系统可实现 1 型糖尿病的全自动血糖控制
  • 批准号:
    10488207
  • 财政年份:
    2021
  • 资助金额:
    $ 61.65万
  • 项目类别:
Translation of the UVA Advanced Automated Insulin Delivery Systems to Clinical Care in Young Children: Glycemic Control, Regulatory Acceptance and Optimization of Day to Day Use
UVA 先进自动胰岛素输送系统在幼儿临床护理中的应用:血糖控制、监管接受和日常使用优化
  • 批准号:
    10474818
  • 财政年份:
    2021
  • 资助金额:
    $ 61.65万
  • 项目类别:
Artificial Pancreas - Adolescent Physiology and Psychology Longitudinal Evaluation (A.P. APPLE)
人工胰腺 - 青少年生理学和心理学纵向评估 (A.P. APPLE)
  • 批准号:
    10381710
  • 财政年份:
    2020
  • 资助金额:
    $ 61.65万
  • 项目类别:
Translation of the UVA Advanced Automated Insulin Delivery Systems to Clinical Care in Young Children: Glycemic Control, Regulatory Acceptance and Optimization of Day to Day Use
UVA 先进自动胰岛素输送系统在幼儿临床护理中的应用:血糖控制、监管接受和日常使用优化
  • 批准号:
    10265602
  • 财政年份:
    2020
  • 资助金额:
    $ 61.65万
  • 项目类别:
Translation of the UVA Advanced Automated Insulin Delivery Systems to Clinical Care in Young Children: Glycemic Control, Regulatory Acceptance and Optimization of Day to Day Use
UVA 先进自动胰岛素输送系统在幼儿临床护理中的应用:血糖控制、监管接受和日常使用优化
  • 批准号:
    10470808
  • 财政年份:
    2020
  • 资助金额:
    $ 61.65万
  • 项目类别:
Models, signals, and distributed bio-behavioral control of exercise in diabetes
糖尿病运动的模型、信号和分布式生物行为控制
  • 批准号:
    8971447
  • 财政年份:
    2015
  • 资助金额:
    $ 61.65万
  • 项目类别:
HYPOGLYCEMIA PREVENTION AFTER EXERCISE IN ADOLESCENT T1DM
青少年 T1DM 运动后低血糖的预防
  • 批准号:
    8167207
  • 财政年份:
    2010
  • 资助金额:
    $ 61.65万
  • 项目类别:
FEASIBILITY STUDY OF A MODULAR CONTROL TO RANGE SYSTEM IN T1DM
T1DM 测距系统模块化控制的可行性研究
  • 批准号:
    8167201
  • 财政年份:
    2010
  • 资助金额:
    $ 61.65万
  • 项目类别:

相似海外基金

Deciphering the role of adipose tissue in common metabolic disease via adipose tissue proteomics
通过脂肪组织蛋白质组学解读脂肪组织在常见代谢疾病中的作用
  • 批准号:
    MR/Y013891/1
  • 财政年份:
    2024
  • 资助金额:
    $ 61.65万
  • 项目类别:
    Research Grant
ESTABLISHING THE ROLE OF ADIPOSE TISSUE INFLAMMATION IN THE REGULATION OF MUSCLE MASS IN OLDER PEOPLE
确定脂肪组织炎症在老年人肌肉质量调节中的作用
  • 批准号:
    BB/Y006542/1
  • 财政年份:
    2024
  • 资助金额:
    $ 61.65万
  • 项目类别:
    Research Grant
Canadian Alliance of Healthy Hearts and Minds: Dissecting the Pathways Linking Ectopic Adipose Tissue to Cognitive Dysfunction
加拿大健康心灵联盟:剖析异位脂肪组织与认知功能障碍之间的联系途径
  • 批准号:
    479570
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
    Operating Grants
Determinants of Longitudinal Progression of Adipose Tissue Inflammation in Individuals at High-Risk for Type 2 Diabetes: Novel Insights from Metabolomic Profiling
2 型糖尿病高危个体脂肪组织炎症纵向进展的决定因素:代谢组学分析的新见解
  • 批准号:
    488898
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
    Operating Grants
Activation of human brown adipose tissue using food ingredients that enhance the bioavailability of nitric oxide
使用增强一氧化氮生物利用度的食品成分激活人体棕色脂肪组织
  • 批准号:
    23H03323
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Development of new lung regeneration therapies by elucidating the lung regeneration mechanism of adipose tissue-derived stem cells
通过阐明脂肪组织干细胞的肺再生机制开发新的肺再生疗法
  • 批准号:
    23K08293
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A study on the role of brown adipose tissue in the development and maintenance of skeletal muscles
棕色脂肪组织在骨骼肌发育和维持中作用的研究
  • 批准号:
    23K19922
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
Adipose Tissue T Cell Polarization and Metabolic Health in Persons Living with HIV
HIV 感染者的脂肪组织 T 细胞极化和代谢健康
  • 批准号:
    10619176
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
下丘脑腹内侧区的雌激素信号调节脂肪组织代谢适应
  • 批准号:
    10604611
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
Obesity and Childhood Asthma: The Role of Adipose Tissue
肥胖和儿童哮喘:脂肪组织的作用
  • 批准号:
    10813753
  • 财政年份:
    2023
  • 资助金额:
    $ 61.65万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了