Ultrasonic and Photoacoustic Imaging System for Cancer & Cardiovascular Research

癌症超声和光声成像系统

• 批准号: 8734742
• 负责人: TOMY VARGHESE
• 金额: $ 90.79万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-06 至 2016-03-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8734742
• 关键词: Adult; Animal Experimentation; Animals; Biological; Biological Models; Blood flow; Businesses; Cancer Center; Cardiovascular system; Discipline; Disease Progression; Disease model; Disease regression; Embryo; Equipment; Fees; Funding; Goals; Imagery; Injection of therapeutic agent; Institutes; Longitudinal Studies; Malignant Neoplasms; Marketing; Medical; Medical Research; Minor; Modeling; Molecular; Monitor; Mus; Needles; Perfusion; Physics; Physiologic Monitoring; Physiological; Public Health; Rattus; Research; Research Personnel; Resolution; Speed; Structure; System; Time; Transducers; Ultrasonography; Wisconsin; animal imaging; base; cancer imaging; image guided; imaging system; in vivo; innovation; instrument; instrumentation; medical schools; photoacoustic imaging; pre-clinical; quantitative imaging; therapeutic effectiveness

DESCRIPTION (provided by applicant): The goal of this shared instrumentation proposal is to develop effective small animal imaging capabilities in the Wisconsin Institutes for Medical Research (WIMR), specifically to implement innovative preclinical ultrasound and photoacoustic imaging capabilities. We are respectfully requesting funds to purchase the Visualsonics Vevo(R) LAZR Photoacoustic Imaging system, with transducers and supporting equipment that will enable superficial and deep imaging of tumors and other disease models, physiological monitoring, and effective high speed recording of perfusion, strain, and molecular tagging agents. This high-resolution, micro imaging system was devised specifically for non-invasive small animal research. It can deliver in vivo visualization of structures at the embryonic level through the adult mouse in real time and has the ability to perform longitudinal studies of disease progression and regression. With resolution of anatomical and physiological structures down to 30 microns and the ability to visualize image-guided needle injection and extraction, microcirculatory and cardiovascular blood flow assessments, the system has applications in many different disciplines that use the mouse, rat or other small animals for its model system. WIMR based investigators of 13 major projects and 8 minor projects describe the integration of the array-based ultrasound and photoacoustic system into their research. The Vevo(R) LAZR not only bolsters existing studies, but also provides exciting and important new information, combining quantitative imaging with advanced biological assessments to monitor progression/regression of disease and effectiveness of therapeutics. Comprehensive educational and marketing plans will inform researchers throughout the UW medical school and campus on ways that the system could enhance their own research. A business model that includes modest user fees and a strong institutional commitment from the Medical Physics department, the Carbone Cancer Center, and the School of Medicine and Public Health assures the system will continue to benefit researchers for the lifetime of the instrument.

描述（由申请人提供）：该共享仪器提案的目标是在威斯康星医学研究所（WIMR）开发有效的小动物成像能力，特别是实施创新的临床前超声和光声成像能力。我们恭敬地申请购买Visualsonics Vevo(R) LAZR光声成像系统的资金，该系统配备传感器和配套设备，可实现肿瘤和其他疾病模型的浅表和深层成像，生理监测，以及灌注、应变和分子标记剂的有效高速记录。这种高分辨率的微成像系统是专门为非侵入性小动物研究而设计的。它可以通过成年小鼠实时提供胚胎水平的体内结构可视化，并具有对疾病进展和消退进行纵向研究的能力。由于解剖和生理结构的分辨率低至30微米，并且能够可视化图像引导针头注射和提取，微循环和心血管血流评估，该系统在许多使用小鼠，大鼠或其他小动物作为其模型系统的不同学科中得到应用。基于WIMR的13个主要项目和8个次要项目的研究人员描述了基于阵列的超声和光声系统与他们研究的集成。Vevo(R) LAZR不仅支持了现有的研究，而且还提供了令人兴奋和重要的新信息，将定量成像与先进的生物学评估相结合，以监测疾病的进展/消退和治疗的有效性。全面的教育和营销计划将告知整个西澳大学医学院和校园的研究人员，该系统可以如何加强他们自己的研究。商业模式包括适度的用户费用和来自医学物理系、Carbone癌症中心和医学与公共卫生学院的强有力的机构承诺，确保该系统将在仪器的使用寿命内继续使研究人员受益。