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Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain Imaging

使用拉格朗日颈动脉应变成像生物标志物早期检测血管功能障碍

基本信息

批准号：
10442390
负责人：
TOMY VARGHESE
金额：
$ 58.18万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10442390
关键词：
3-Dimensional Age Age-Years Aging Algorithms Arterial Fatty Streak Arteries Atherosclerosis Biochemical Biological Markers Blood Blood Pressure Blood Vessels Blood flow Cardiac Carotid Arteries Carotid Endarterectomy Cerebrovascular system Characteristics Classification Clinical Code Cognition Color Deposition Development Disease Early Diagnosis Embolism Fostering Frequencies General Population Goals Grant Guidelines Histopathology Human Volunteers Hyperlipidemia Hypertension Image Individual Intervention Lateral Lead Life Style Modification Lipids Location Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Medical Methods Modulus Noise Pathologic Patients Performance Physiologic pulse Physiological Population Populations at Risk Protocols documentation Research Risk Rupture Scanning Screening procedure Sequoia Severities Signal Transduction Stenosis Stream Stress Stroke Structure Subgroup System Therapeutic Embolization Time Tissues Ulcer Ultrasonography Validation Variant Vascular Cognitive Impairment Vascular Diseases Work age group age related base clinical imaging clinically significant cost feeding high risk population human data human subject imaging approach imaging study improved in vivo indexing innovation interest mechanical properties novel novel strategies plaque lesion pressure reconstruction response screening trend ultrasound vascular risk factor volunteer

项目摘要

Abstract Current clinical criteria for treatment of atherosclerotic plaque, or atheromas, have focused primarily on percent stenosis of the vessel. However, measures of occlusion (percent stenosis) do not identify those plaques that are prone to rupture, which may release emboli into the blood stream feeding sensitive cerebral vasculature. A novel approach, Lagrangian carotid strain imaging, where tissue displacements are precisely measured during pulsation of blood through the artery has been developed. We propose to measure `strain indices,' that include the maximum accumulated axial, lateral, and shear strain estimated over the cardiac cycle, to probe the detailed mechanical properties of early plaque. We believe these strain indices will prove to be valuable vascular biomarkers to indicate vascular aging and possible plaque vulnerability. Our preliminary results demonstrate the ability to differentiate between soft and stiff regions in plaque under in-vivo clinical imaging conditions. Our definition of `vulnerable plaque' or `vulnerable patient' relies on the identification of lipidic depositions or softer plaques, i.e., those that undergo large axial or lateral deformations and/or large shearing strains during the cardiac cycle. Capability of strain tensor imaging and vascular biomarkers to characterize plaque severity from its early stages to a mature plaque lesion will be evaluated and quantified. A study on asymptomatic volunteers and patients also is proposed. The volunteer will provide values for vascular strain indices normalized to age-related vascular stiffening. The results will enable us to establish trends in age-related variations in vascular stiffness and to determine deviations that could establish vascular aging criteria. Interventions to reverse vascular aging might then be used, for example lifestyle modifications and common medical therapies. Strain imaging results will be validated and complimented by three- dimensional (3D) carotid magnetic resonance imaging (MRI) on a selected group of high-risk volunteers, along with 3D carotid MRI and 3D histopathological analysis of the entire excised plaque on patients to better understand plaque composition and structure. Validation of our results will foster use of real-time noninvasive ultrasound strain imaging as a screening tool for identifying human subjects susceptible to vascular aging and/or developing plaque prone to rupture or micro-embolization that could lead to `silent strokes' and possible vascular cognitive impairment. The patient study will also enable comparison of strain indices and carotid MRI to the ground truth, namely the excised plaque.

摘要