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microRNA Profiling in the Spectrum of Kidney Tumors

microRNA Profiling in the Spectrum of Kidney Tumors
肾肿瘤谱中的 microRNA 分析
批准号：
9153894
负责人：
Maria Merino
金额：
$15.9万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9153894
关键词：
Biological MarkersCell SurvivalClear CellClinicalCodeDataDevelopmentDiagnosisDisease OutcomeGene ExpressionGene TargetingGoalsHereditary Leiomyomatosis and Renal Cell CancerHistologicHumanKidney NeoplasmsLinkMalignant NeoplasmsMessenger RNAMicroRNAsMolecular Classification of TumorsOncogenesPapillaryPlayPost-Transcriptional RegulationProteinsRegulationRenal carcinomaRoleSmall RNATranscriptTumor Suppressor Geneshuman diseasenoveltumor

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中文摘要
翻译
在初步研究中，我们已经确定了每个肾肿瘤组织学亚型的独特特征。下调mirna的表达值从0.3倍（在VHL-clear细胞RCC中）到0.393倍（在Pap-II HLRCC肿瘤中）不等。透明细胞肿瘤（散发性和透明细胞）中常见缺失的mirna包括miR-184和miR-206，而miR-122和-143在乳头状I型肿瘤中最常下调。我们的数据支持miR-92a和miR-210参与透明细胞肿瘤的假设。ccRCC表达miR92a量增加，这些肿瘤显示VHL mRNA水平下降，支持microRNAs可能影响RCC中蛋白编码靶基因转录丰度的概念。
英文摘要
In a preliminary study, we have identified unique signatures for each histologic subtype of kidney tumors. Expression values for downregulated miRNAs ranged from 0.3-fold (in VHL-clear cell RCC) up to 0.393 fold (in Pap-II HLRCC tumors). Commonly lost miRNAs in clear cell tumors (both sporadic and clear cell) included miR-184 and miR-206, while miR-122 and -143 were the most commonly downregulated in Papillary type I tumors.Our data supports the hypothesized involvement of miR-92a and miR-210 in clear cell tumors. ccRCC expressed increased amount of miR92a and these tumors showed decreased levels of VHL mRNA, supporting the concept that microRNAs may influence transcript abundance of protein-coding target genes in RCC.
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microRNA Profiling in the Spectrum of Kidney Tumors
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microRNA Profiling in the Spectrum of Kidney Tumors
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