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microRNA Profiling in the Spectrum of Kidney Tumors

microRNA Profiling in the Spectrum of Kidney Tumors
肾肿瘤谱中的 microRNA 分析
批准号：
10486835
负责人：
Maria Merino
金额：
$23.55万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10486835
关键词：
Cell SurvivalClear CellClear cell renal cell carcinomaClinicalCodeDataDevelopmentDiagnosisDisease OutcomeGene Expression RegulationGenesGoalsHereditary Leiomyomatosis and Renal Cell CancerHistologicHumanKidney NeoplasmsLinkMalignant NeoplasmsMessenger RNAMicroRNAsMolecular Classification of TumorsOncogenesPapillaryPhylogenetic AnalysisPlayPost-Transcriptional RegulationProteinsRegulationRenal carcinomaRoleSmall RNATranscriptTumor Suppressor Geneshuman diseasemiRNA expression profilingneoplastic cellnovel markerpotential biomarkertumor

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英文摘要
In a preliminary study, we have identified unique signatures for each histologic subtype of kidney tumors. Expression values for downregulated miRNAs ranged from 0.3-fold (in VHL-clear cell RCC) up to 0.393 fold (in Pap-II HLRCC tumors). Commonly lost miRNAs in clear cell tumors (both sporadic and clear cell) included miR-184 and miR-206, while miR-122 and -143 were the most commonly downregulated in Papillary type I tumors. Our data supports the hypothesized involvement of miR-92a and miR-210 in clear cell tumors. ccRCC expressed increased amount of miR92a and these tumors showed decreased levels of VHL mRNA, supporting the concept that microRNAs may influence transcript abundance of protein-coding target genes in RCC.
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microRNA Profiling in the Spectrum of Kidney Tumors
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