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microRNA Profiling in the Spectrum of Kidney Tumors

microRNA Profiling in the Spectrum of Kidney Tumors
肾肿瘤谱中的 microRNA 分析
批准号：
10926202
负责人：
Maria Merino
金额：
$16.68万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10926202
关键词：
Cell SurvivalClear CellClear cell renal cell carcinomaClinicalCodeDataDevelopmentDiagnosisDisease OutcomeGene Expression RegulationGenesGoalsHereditary Leiomyomatosis and Renal Cell CancerHistologicHumanKidney NeoplasmsLinkMalignant NeoplasmsMessenger RNAMicroRNAsMolecular Classification of TumorsOncogenesPapillaryPhylogenetic AnalysisPlayPost-Transcriptional RegulationProliferatingProteinsRegulationRenal carcinomaRoleSmall RNATranscriptTumor Suppressor Geneshuman diseasemiRNA expression profilingneoplastic cellnovel markerpotential biomarkertumor

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中文摘要
翻译
在一项初步研究中，我们已经确定了肾脏肿瘤的每种组织学亚型的独特特征。下调的miRNA的表达值范围从0.3倍（在VHL-透明细胞RCC中）至0.393倍（在Pap-II HLRCC肿瘤中）。透明细胞肿瘤（散发性和透明细胞）中常见的丢失的miRNA包括miR-184和miR-206，而miR-122和-143在乳头状I型肿瘤中最常见的下调。我们的数据支持miR-92 a和miR-210参与透明细胞肿瘤的假设。ccRCC表达增加量的miR 92 a，并且这些肿瘤显示VHL mRNA水平降低，支持microRNA可能影响RCC中蛋白编码靶基因的转录丰度的概念。
英文摘要
In a preliminary study, we have identified unique signatures for each histologic subtype of kidney tumors. Expression values for downregulated miRNAs ranged from 0.3-fold (in VHL-clear cell RCC) up to 0.393 fold (in Pap-II HLRCC tumors). Commonly lost miRNAs in clear cell tumors (both sporadic and clear cell) included miR-184 and miR-206, while miR-122 and -143 were the most commonly downregulated in Papillary type I tumors. Our data supports the hypothesized involvement of miR-92a and miR-210 in clear cell tumors. ccRCC expressed increased amount of miR92a and these tumors showed decreased levels of VHL mRNA, supporting the concept that microRNAs may influence transcript abundance of protein-coding target genes in RCC.
期刊论文(29)
专著(0)
科研奖励(0)
会议论文
Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer.
DOI： 10.1038/onc.2011.179
发表时间： 2011-11-24
期刊： ONCOGENE
影响因子： 8
作者： [Cherkasova, E., Malinzak, E., Rao, S., Takahashi, Y., Senchenko, V. N., Kudryavtseva, A. V., Nickerson, M. L., Merino, M., Hong, J. A., Schrump, D. S., Srinivasan, R., Linehan, W. M., Tian, X., Lerman, M. I., Childs, R. W.]
通讯作者： Childs, R. W.
Comprehensive genomic and phenotypic characterization of germline FH deletion in hereditary leiomyomatosis and renal cell carcinoma.
DOI： 10.1002/gcc.22452
发表时间： 2017-06
期刊： Genes, chromosomes & cancer
影响因子： --
作者： [Vocke CD, Ricketts CJ, Merino MJ, Srinivasan R, Metwalli AR, Middelton LA, Peterson J, Yang Y, Linehan WM]
通讯作者： Linehan WM
Determinants and prognostic implications of malignant ascites in metastatic papillary renal cancer.
转移性乳头状肾癌恶性腹水的决定因素和预后意义。
DOI： 10.1016/j.urolonc.2016.10.023
发表时间： 2017
期刊： Urologic oncology
影响因子： --
作者： [Sidana,Abhinav, Kadakia,Meet, Friend,JuliaC, Krane,LouisS, Su,Daniel, Merino,MariaJ, Srinivasan,Ramaprasad]
通讯作者： Srinivasan,Ramaprasad
Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer.
DOI： 10.1016/j.juro.2013.06.012
发表时间： 2013-12
期刊： JOURNAL OF UROLOGY
影响因子： 6.6
作者： [Shuch, Brian, Ricketts, Christopher J., Vocke, Cathy D., Komiya, Takefumi, Middelton, Lindsay A., Kauffman, Eric C., Merino, Maria J., Metwalli, Adam R., Dennis, Phillip, Linehan, W. Marston]
通讯作者： Linehan, W. Marston
共 20 条
    microRNA Profiling in the Spectrum of Kidney Tumors
    miRNA profiling of prostate cancer.
    Translational Surgical Pathology
    microRNA Profiling in the Spectrum of Kidney Tumors
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