2014 Cornea, Biology & Pathobiology Gordon Research Conference Gordon Research Se

2014 角膜，生物学

• 批准号: 8641527
• 负责人: WINSTON W KAO
• 金额: $ 3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8641527
• 关键词: Address; Area; Attention; Biochemistry; Biology; Blindness; California; Cell Differentiation process; Cell Lineage; Cells; Clinic; Clinical; Collaborations; Collection; Cornea; Corneal Diseases; Corneal Endothelium; Data; Development; Discipline; Disease; Endothelial Cells; Environment; Epithelial Cells; Epithelium; Event; Eye diseases; Eyelid structure; Faculty; Floor; Fostering; Future; Gland; Goals; Grant; Health; Hepatocyte; Homeostasis; Image; Immune; Knowledge; Lacrimal gland structure; Maintenance; Mesenchymal; Molecular; Molecular Genetics; Molecular and Cellular Biology; Morphogenesis; Natural regeneration; Neural Crest Cell; Ophthalmology; Pathogenesis; Pathology; Postdoctoral Fellow; Publishing; Request for Proposals; Research; Research Personnel; Scientist; Surface Ectoderm; Time; Tissue Engineering; Tissues; Translations; Treatment Protocols; Vision; Work; Writing; career; cell type; conjunctiva; corneal epithelium; data exchange; design; experience; graduate student; improved; innovation; meetings; meibomian gland; migration; novel; ocular surface; planetary Atmosphere; posters; programs; public health relevance; restoration; structural biology; symposium; tissue reconstruction; trend

DESCRIPTION (provided by applicant): This proposal requests partial support for the third Gordon Research Conference (GRC) and the first Gordon Research Seminar (GRS) on Cornea, the Biology and Pathobiology of, in Ventura, California, February, 16-21 (GRC), and February 15 -16 (GRS) 2014. The broad and long-term goal of this Cornea-GRC & GRS is to reduce corneal blindness by fostering innovation in corneal research. Researchers and trainees will be brought together to exchange data and educate one another in a GRC format (about 165 attendees including 50-60 GRS attendees) that enables cross-disciplinary discussions and collaborations. As a result, it will improve our understanding of corneal biology and pathobiology and foster development of new treatment regimens for diseases causing corneal blindness. The theme of the third GRC: Cornea, Biology and Pathobiology will be cutting edge research examining the cell lineage and cell fate of ocular surface tissues, e.g., cornea, conjunctiva, eyelid, lacrimal glands, and Meibomian glands, during development and pathogenesis. Morpho- genesis of ocular surface tissues during development involves two major cellular events: 1. the migration and differentiation of particular mesenchymal cells of neural crest origin for the formation of ocular tissue stromal, 2. differentiation of surface ectoderm into ocular surface epithelia and glands. A better understanding of the molecular and cellular mechanisms governing the orderly migration and differentiation of cells during development will aid in the design of treatment regimens for the restoration of tissue function lost by eye disease. Invited speakers represent a variety of scientific disciplines, including molecular and cellular biology, molecular genetics, biochemistry, structural biology, imaging, tissue engineering, tissue reconstruction and clinical ophthalmology. The Conference will bring together a collection of investigators who are at the forefront of ocular surface biology, and will provide opportunities fo young investigators including graduate students, post docs and early career researchers to present their work and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks in GRC. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross- disciplinary collaborations in the various research areas represented. The GRS is targeted for graduate students, post-docs, early-career scientists and young faculty providing unique forum for young investigators to discuss their work in a less intimidating environment, however, in a GRC setting. The principal topic of the GRS is The Future Directions of Corneal Research which aims to give the young investigators a notion of the new trends and new directions of cornea/ocular surface tissue research to help them design and plan their future line of research. Moreover, the meeting will have a unique Session on "How to Write a Competitive Grant" followed by an open floor discussion, which is a vital step in a young investigators career.

描述(由申请人提供)：本提案请求部分支持2014年2月16日至21日(GRC)和2月15日至16日(GRS)在加利福尼亚州文图拉举行的第三届戈登研究会议(GRC)和第一届戈登研究研讨会(GRS)，主题是角膜、角膜的生物学和病理生物学。这种角膜-GRC和GRS的广泛和长期目标是通过促进角膜研究的创新来减少角膜失明。研究人员和受训人员将被聚集在一起，以GRC形式(约165名与会者，包括50-60名GRS与会者)交换数据并相互教育，从而实现跨学科讨论和合作。因此，它将提高我们对角膜生物学和病理生物学的理解，并促进导致角膜失明疾病的新治疗方案的开发。第三届GRC：角膜、生物学和病理生物学的主题将是研究眼表组织的细胞谱系和细胞命运的前沿研究，例如，角膜、结膜、眼皮、泪腺和眉板腺在发育和发病机制中的细胞谱系和细胞命运。眼表组织发育过程中的形态发生涉及两个主要的细胞事件：1.特定的神经脊来源的间充质细胞的迁移和分化以形成眼组织基质；2.表面外胚层分化为眼表上皮和腺体。更好地了解调控细胞在发育过程中有序迁移和分化的分子和细胞机制，将有助于设计治疗方案，以恢复因眼病而丧失的组织功能。特邀演讲者代表了各种科学学科，包括分子和细胞生物学、分子遗传学、生物化学、结构生物学、成像、组织工程、组织重建和临床眼科。会议将汇集一批处于眼表生物学前沿的研究人员，并将为包括研究生、博士后和职业生涯早期研究人员在内的年轻研究人员提供机会，介绍他们的工作并与该领域的领导人交流意见。一些海报主持人将被选中在GRC进行简短的演讲。这次会议气氛热烈，有计划的讨论会议以及在下午和晚上举行非正式聚会的机会，为来自不同学科的科学家提供了集思广益的途径，并促进了所代表的不同研究领域的跨学科合作。GRS面向研究生、博士后、早期职业科学家和年轻教职员工，为年轻研究人员提供了独特的论坛，让他们在一个不那么吓人的环境中讨论他们的工作，但在GRC环境中。GRS的主要主题是角膜研究的未来方向，旨在让年轻的研究人员对角膜/眼表组织研究的新趋势和新方向有一个概念，以帮助他们设计和规划未来的研究路线。此外，会议将举行一次独特的“如何撰写竞争性补助金”会议，然后进行公开讨论，这是年轻调查人员职业生涯中至关重要的一步。