FDA FERN Cooperative Agreement Program

项目摘要 2010年深水地平线石油钻井平台爆炸和婴儿配方奶粉等大型事件 在中国故意强化三聚氰胺引起高度关注，提高认识水平 食品安全的重要性。地方、州和国家响应机制已经到位， 快速响应这些情况，帮助减轻意外后果，同时保护 公共和环境卫生。不幸的是，每个级别的响应资产都可能很快成为 不堪重负，可能需要激增或冗余容量。美国食品和药物管理局 应急响应网络（FDA FERN）是一个由联邦 和国家实验室，将人员、物资、设备和专业知识汇集在一起， 在这些情况下进行食品和食品产品分析。许多实验室是志愿者实验室， 但已有14个成员实验室签订了化学分析合作协议， 现称为FERNCCAP实验室。阿肯色州卫生部-阿肯色州公共卫生部 健康实验室（ADH-PHL）于2009年成为FERN cCAP实验室，并建立了强大的 食品化学分析，方法开发和应急响应的基础。 ADH-PHL为保持阿肯色州蕨类植物提供了最先进的实验室环境 化学实验室专用实验室空间、技术专长、质量管理体系， ISO 17025认证以及额外的支持人员，仪器和空间都是可用的 必要时整个实验室的工作人员在GC-MS、LC-MS、MS- MS、ICP-MS和ELISA。ADH-PHL还与其他联邦响应网络合作， 疾病控制中心和环境保护局，其中ADH-PHL已 在州内和全国范围内行使和利用事故指挥中心。这 知识对于缓解食品安全和人类健康受到严重威胁的大规模危机至关重要。 濒临灭绝 阿肯色州蕨类植物化学实验室继续努力扩大和提高能力 通过与其他cCAP实验室和FDA的密切合作，实验室人员配备齐全， 继续交叉培训，并验证GC-MS，LC-MS，ICP-MS的FERN测试方法， ELISA平台。实验室继续参加FDA提供的所有能力验证， 通过开发新的方法，成功地参与了 这些能力测试实验室参加所有技术和方案会议， 包括电话会议。目前，FERN分析师正在积极参与两个大型的，多 实验室方法验证。在过去，该实验室分析了许多食物基质， 包括奶粉、冻干金枪鱼、菠菜、柑橘、菠萝汁、巧克力 糖浆，大豆婴儿配方奶粉，点心蛋糕，能量饮料，饮用酸奶，沙拉酱，鲶鱼， 烈酒，荷兰豆，苹果酱，白软干酪，红糖，瓶装水，谷类食品，婴儿食品，水果 果汁和剑鱼。此外，实验室还参与了监测活动，包括 政治惯例和分析果汁中的砷 该合作协议的项目计划继续与FDA密切合作， 积极响应食品安全倡议，同时保持 通过参加应急准备能力测试，交叉培训人员，提供额外的 快速部署支助，并继续参加技术和国家会议及电话会议。 FDA和其他FERN合作伙伴提供的培训课程也将用于了解最新信息， FERN使用的最新技术项目计划还包括对矩阵的承诺 评估、分析物扩展、方法验证和新方法开发。

Project Summary Large scale events like the Deepwater Horizon Oil Rig Explosion of 2010 and infant formula purposely fortified with melamine in China cause great concern and heighten the level of awareness of the importance of food safety. Local, state, and national response mechanisms are in place to quickly respond to these situations and help mitigate unforeseen consequences while protecting public and environmental health. Unfortunately, response assets at every level can quickly become overwhelmed and may require surge or redundant capacity. The Food and Drug Administration Food Emergency Response Network (FDA FERN) is one system in place that is comprised of both federal and state laboratories that bring personnel, supplies, equipment, and expertise together to enable food and food product analyses during these situations. Many laboratories are volunteer laboratories, but 14 member laboratories have entered cooperative agreements for chemistry analysis and are now referred to as FERN cCAP Laboratories. The Arkansas Department of Health-Arkansas Public Health Laboratory (ADH-PHL) became a FERN cCAP Laboratory in 2009 and has built a strong foundation for food chemical analyses, method development, and emergency response. ADH-PHL provides a state-of-the-art laboratory environment for maintaining the Arkansas FERN Chemistry Laboratory. Dedicated laboratory space, technical expertise, quality management systems, ISO 17025 accreditation as well as additional support staff, instrumentation, and space are available if necessary. The entire laboratory staff has experience in the four key project areas of GC-MS, LC- MS, ICP-MS, and ELISA. ADH-PHL also partners with other federal response networks managed by the Centers for Disease Control and the Environmental Protection Agency where ADH-PHL has exercised and utilized the Incident Command Center within the state as well as nationally. This knowledge is crucial for mitigating large scale crises where food safety and human health is endangered. The Arkansas FERN Chemistry Laboratory continues to work to expand and enhance the capabilities of FERN by working closely with other cCAP laboratories and FDA. The laboratory is fully staffed, continues to cross-train, and validates FERN testing methods on GC-MS, LC-MS, ICP-MS, and ELISA platforms. The laboratory continues to participate in all proficiency tests provided by FDA and has exercised its response capabilities by developing new methods to successfully participate in these proficiency tests. The laboratory participates in all technical and programmatic meetings, which includes conference calls. Currently, FERN analysts are actively involved in two, large, multi- laboratory method validations. In the past, the laboratory has analyzed numerous food matrices including powdered milk, freeze-dried tuna, spinach, mandarin oranges, pineapple juice, chocolate syrup, soy-based baby formula, snack cakes, energy drinks, drinkable yogurt, salad dressing, catfish, spirits, snow peas, applesauce, cottage cheese, brown sugar, bottled water, cereal, baby food, fruit juice and swordfish. Also, the laboratory has participated in surveillance activities, including the political conventions and analyzing arsenic in juice. The project plan for this cooperative agreement continues to work closely with FDA to develop new methods that are necessary for proactively responding to food safety initiatives while maintaining emergency preparedness by participating in proficiency tests, cross-training staff to provide additional surge support, and continued participation technical and national meetings and conference calls. Training sessions provided by FDA and other FERN partners will also be used to stay up-to-date of the newest technology used by FERN. The project plan also includes commitments for matrix evaluations, analyte extension, method validations and new method development.