FDA FERN Cooperative Agreement Program

项目摘要 2010年深水地平线石油钻井平台爆炸和婴儿配方奶粉等大型事件 中国被故意强化三聚氰胺引起高度关注并提高认识水平 食品安全的重要性。地方、州和国家都建立了应对机制 快速应对这些情况，帮助减轻不可预见的后果，同时保护 公共和环境健康。不幸的是，每个级别的响应资产都可能很快变成 不堪重负，可能需要激增或冗余容量。美国食品药品监督管理局 紧急响应网络(FDA FERN)是一个由联邦政府和 以及国家实验室，将人员、用品、设备和专业知识聚集在一起，以实现 在这些情况下进行食品和食品分析。许多实验室都是志愿者实验室， 但已有14个成员实验室签订了化学分析合作协议，并 现在被称为蕨类CCAP实验室。阿肯色州卫生部-阿肯色州公共卫生 健康实验室(ADH-PHL)于2009年成为蕨类CCAP实验室，并建立了强大的 食品化学分析、方法开发和应急响应基金会。 ADH-PHL为维护阿肯色州蕨类植物提供最先进的实验室环境 化学实验室。专门的实验室空间、技术专长、质量管理体系、 ISO 17025认证以及额外的支持人员、仪器设备和空间可用 如果有必要的话。所有实验室工作人员在GC-MS、LC-MS的四个关键项目领域都有经验- MS、电感耦合等离子体质谱(ICPMS)和酶联免疫吸附试验(ELISA)。ADH-PHL还与由管理的其他联邦响应网络合作 ADH-PHL所在的疾病控制中心和环境保护局 在州内和全国范围内行使和使用事故指挥中心。这 知识对于缓解食品安全和人类健康面临的大规模危机至关重要 濒临灭绝。 阿肯色州蕨类化学实验室继续努力扩大和增强 通过与CCAP其他实验室和FDA密切合作，对蕨类植物进行研究。实验室的人员配备齐全， 继续交叉培训，并验证GC-MS、LC-MS、ICP-MS和 酶联免疫吸附试验平台。实验室继续参加FDA提供的所有熟练程度测试 通过开发成功参与的新方法来行使其应对能力 这些能力测试。实验室参加所有技术和方案会议，这些会议 包括电话会议。目前，Fern分析师正积极参与两个、大型、多个 实验室方法验证。在过去，该实验室分析了大量的食物基质 包括奶粉、冻干金枪鱼、菠菜、橘子、菠萝汁、巧克力 糖浆，豆基婴儿配方奶粉，零食蛋糕，能量饮料，可饮用酸奶，沙拉酱，鲶鱼， 烈酒，雪豌豆，苹果酱，白干酪，红糖，瓶装水，谷类食品，婴儿食品，水果 果汁和剑鱼。此外，该化验所亦曾参与监察活动，包括 政治惯例和果汁中砷的分析。 该合作协议的项目计划继续与FDA密切合作，开发新的 在积极响应食品安全倡议的同时保持 通过参加能力测试、交叉培训等方式为应急准备人员提供额外的 提供大量支持，并继续参加技术和国家会议及电话会议。 FDA和其他FERN合作伙伴提供的培训课程也将用于了解最新情况 芬使用的最新技术。项目计划还包括对矩阵的承诺 评估、分析物扩展、方法验证和新方法开发。

Project Summary Large scale events like the Deepwater Horizon Oil Rig Explosion of 2010 and infant formula purposely fortified with melamine in China cause great concern and heighten the level of awareness of the importance of food safety. Local, state, and national response mechanisms are in place to quickly respond to these situations and help mitigate unforeseen consequences while protecting public and environmental health. Unfortunately, response assets at every level can quickly become overwhelmed and may require surge or redundant capacity. The Food and Drug Administration Food Emergency Response Network (FDA FERN) is one system in place that is comprised of both federal and state laboratories that bring personnel, supplies, equipment, and expertise together to enable food and food product analyses during these situations. Many laboratories are volunteer laboratories, but 14 member laboratories have entered cooperative agreements for chemistry analysis and are now referred to as FERN cCAP Laboratories. The Arkansas Department of Health-Arkansas Public Health Laboratory (ADH-PHL) became a FERN cCAP Laboratory in 2009 and has built a strong foundation for food chemical analyses, method development, and emergency response. ADH-PHL provides a state-of-the-art laboratory environment for maintaining the Arkansas FERN Chemistry Laboratory. Dedicated laboratory space, technical expertise, quality management systems, ISO 17025 accreditation as well as additional support staff, instrumentation, and space are available if necessary. The entire laboratory staff has experience in the four key project areas of GC-MS, LC- MS, ICP-MS, and ELISA. ADH-PHL also partners with other federal response networks managed by the Centers for Disease Control and the Environmental Protection Agency where ADH-PHL has exercised and utilized the Incident Command Center within the state as well as nationally. This knowledge is crucial for mitigating large scale crises where food safety and human health is endangered. The Arkansas FERN Chemistry Laboratory continues to work to expand and enhance the capabilities of FERN by working closely with other cCAP laboratories and FDA. The laboratory is fully staffed, continues to cross-train, and validates FERN testing methods on GC-MS, LC-MS, ICP-MS, and ELISA platforms. The laboratory continues to participate in all proficiency tests provided by FDA and has exercised its response capabilities by developing new methods to successfully participate in these proficiency tests. The laboratory participates in all technical and programmatic meetings, which includes conference calls. Currently, FERN analysts are actively involved in two, large, multi- laboratory method validations. In the past, the laboratory has analyzed numerous food matrices including powdered milk, freeze-dried tuna, spinach, mandarin oranges, pineapple juice, chocolate syrup, soy-based baby formula, snack cakes, energy drinks, drinkable yogurt, salad dressing, catfish, spirits, snow peas, applesauce, cottage cheese, brown sugar, bottled water, cereal, baby food, fruit juice and swordfish. Also, the laboratory has participated in surveillance activities, including the political conventions and analyzing arsenic in juice. The project plan for this cooperative agreement continues to work closely with FDA to develop new methods that are necessary for proactively responding to food safety initiatives while maintaining emergency preparedness by participating in proficiency tests, cross-training staff to provide additional surge support, and continued participation technical and national meetings and conference calls. Training sessions provided by FDA and other FERN partners will also be used to stay up-to-date of the newest technology used by FERN. The project plan also includes commitments for matrix evaluations, analyte extension, method validations and new method development.