Sex differences in amygdala function
杏仁核功能的性别差异
基本信息
- 批准号:8654409
- 负责人:
- 金额:$ 38.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-12-10 至 2018-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectiveAmygdaloid structureAntidepressive AgentsAnxietyAnxiety DisordersBehaviorBehavioralBiochemicalCalciumChronic stressDevelopmentDiseaseEffectivenessEnzymesEquilibriumEstrous CycleFemaleFrightFunctional disorderGene ExpressionGenerationsGoalsHigh PrevalenceImpairmentIn VitroIncidenceIon ChannelLateralLeadMediatingMental DepressionMental HealthMental disordersMetestrusModelingMood DisordersNeurobiologyNeuronsOutputPathologyPharmaceutical PreparationsPhasePhysiologyPredispositionProestrusPsychopathologyPublic HealthRattusRegulationRelative (related person)ResearchRiskRodentRoleSeveritiesSex CharacteristicsSex FunctioningSpecificityStimulusStressStructure of terminal stria nuclei of preoptic regionSymptomsTechniquesTestingTherapeuticWestern BlottingWomanawakebalance testingclinical efficacyconditioned feardepressive symptomsemotion regulationhuman femalein vivoinnovationinsightmalemenneuronal excitabilitynovelnovel therapeutic interventionprotein expressionpublic health relevancerestraint stresssex
项目摘要
Project Summary
Despite a higher incidence of mood and anxiety disorders in females, and sex differences in the expression of
symptoms, the neurobiological underpinnings of sex differences in affective behaviors are not well
understood. Dysfunction of the amygdala contributes to these disorders, yet it is unknown whether there are
sex differences in amygdala neuronal function, or in amygdala susceptibility in psychopathology. Targeting of
sex differences in amygdala pathology is expected to provide a novel therapeutic approach for the treatment of
affective disorders. The objective of this project is to test whether differences exist in amygdala physiology and
function in females and males, and whether a stress model that shares features with mood disorders exerts
sex-dependent effects on the amygdala. This project will test the central hypothesis that the basolateral
amygdala (BLA) in females is more responsive than the BLA in males, that this difference is specific for
subcircuits of BLA neurons, and that stress decreases neuronal excitability and function of the BLA in females,
but exerts opposite effects on BLA function in males. This project will test the contribution of ion channels that
regulate BLA neuronal excitability to the sex differences, and key enzymes that modulate the function of these
ion channels. In addition, this project will also test whether pharmacological manipulation of these novel ion
channel and enzymatic targets reverses the behavioral impact of stress. The rationale for these studies is that
the mechanism for sex differences in amygdala-dependent behaviors and the impact of stress on these
behaviors is not known. These issues need to be understood to determine the role of the amygdala in sex
differences in mood disorder symptomology. The Aims of this proposal are to test if sex differences in BLA
neuronal excitability is specific for BLA subcircuits, if the effects of repeated stress on BLA function are sex
dependent, and if the effects can be reversed in a sex-dependent manner. This will be tested using in vivo and
in vitro electrophysiological approaches, combined with biochemical and behavioral approaches. These Aims
are expected to demonstrate sex differences in the physiology of the BLA, the effects of repeated stress on BLA
physiology and function, and that pharmacological targeting of the effects of stress will reverse impairments in
a sex-dependent manner. This can lead to novel insight into the cause of sex differences in mood and anxiety
disorders, and lead to a novel sex-dependent therapeutic approach for rapid treatment of mood disorders.
项目摘要
尽管女性中情绪和焦虑障碍的发病率较高,并且在表达上存在性别差异,
症状,情感行为的性别差异的神经生物学基础并不好
明白杏仁核的功能障碍会导致这些疾病,但目前还不清楚是否有
杏仁核神经元功能的性别差异,或精神病理学中杏仁核易感性的性别差异。靶向
杏仁核病理学的性别差异有望为治疗
情感障碍这个项目的目的是测试杏仁核生理学是否存在差异,
功能的女性和男性,以及是否有一个压力模型,共享功能与情绪障碍发挥
对杏仁核的性别依赖影响这个项目将测试中心假设,基底外侧
女性的杏仁核(BLA)比男性的BLA更敏感,这种差异是特定于
BLA神经元的子回路,并且应激降低了女性BLA的神经元兴奋性和功能,
但在男性中对BLA功能产生相反的影响。该项目将测试离子通道的贡献,
调节BLA神经元兴奋性的性别差异,以及调节这些功能的关键酶
离子通道此外,本项目还将测试这些新离子的药理学操作是否
通道和酶靶点逆转应激的行为影响。这些研究的基本原理是,
杏仁核依赖行为性别差异的机制以及应激对这些行为的影响
行为是未知的。这些问题需要了解,以确定杏仁核在性行为中的作用
在情绪障碍病理学上的差异。本提案的目的是测试BLA中的性别差异
如果重复应激对BLA功能的影响与性别有关,则神经元兴奋性对BLA子回路具有特异性
依赖性,以及这种影响是否可以以性别依赖的方式逆转。这将在体内进行测试,
体外电生理方法,结合生物化学和行为方法。这些目标
预计将证明BLA生理学的性别差异,重复应激对BLA的影响,
生理学和功能,以及针对压力影响的药理学靶向将逆转
依赖性别的方式。这可能导致对情绪和焦虑的性别差异的原因的新见解
的研究,并导致一种新的性别依赖性的治疗方法,用于快速治疗情绪障碍。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jeremy E Rosenkranz其他文献
Adaptation to capsaicin burn: effects of concentration and individual differences
对辣椒素烧伤的适应:浓度和个体差异的影响
- DOI:
- 发表时间:
2001 - 期刊:
- 影响因子:2.9
- 作者:
D. Mcburney;C. Balaban;Justin R Popp;Jeremy E Rosenkranz - 通讯作者:
Jeremy E Rosenkranz
Jeremy E Rosenkranz的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jeremy E Rosenkranz', 18)}}的其他基金
Parallel maturation of social behaviors and amygdala circuits
社会行为和杏仁核回路的平行成熟
- 批准号:
9763157 - 财政年份:2019
- 资助金额:
$ 38.63万 - 项目类别:
Parallel maturation of social behaviors and amygdala circuits
社会行为和杏仁核回路的平行成熟
- 批准号:
10078130 - 财政年份:2019
- 资助金额:
$ 38.63万 - 项目类别:
Parallel maturation of social behaviors and amygdala circuits
社会行为和杏仁核回路的平行成熟
- 批准号:
10377909 - 财政年份:2019
- 资助金额:
$ 38.63万 - 项目类别:
Parallel maturation of social behaviors and amygdala circuits
社会行为和杏仁核回路的平行成熟
- 批准号:
10542777 - 财政年份:2019
- 资助金额:
$ 38.63万 - 项目类别:
Effects of repeated stress on amygdala function during adolescence
青春期反复应激对杏仁核功能的影响
- 批准号:
9223732 - 财政年份:2016
- 资助金额:
$ 38.63万 - 项目类别:
Effects of repeated stress on amygdala function during adolescence
青春期反复应激对杏仁核功能的影响
- 批准号:
9076533 - 财政年份:2016
- 资助金额:
$ 38.63万 - 项目类别:
Effects of chronic stress on amygdala physiology
慢性压力对杏仁核生理的影响
- 批准号:
7888391 - 财政年份:2009
- 资助金额:
$ 38.63万 - 项目类别:
Effects of chronic stress on amygdala physiology
慢性压力对杏仁核生理的影响
- 批准号:
8067177 - 财政年份:2009
- 资助金额:
$ 38.63万 - 项目类别:
Effects of chronic stress on amygdala physiology
慢性压力对杏仁核生理的影响
- 批准号:
7731194 - 财政年份:2009
- 资助金额:
$ 38.63万 - 项目类别:
Effects of chronic stress on amygdala physiology
慢性压力对杏仁核生理的影响
- 批准号:
8461992 - 财政年份:2009
- 资助金额:
$ 38.63万 - 项目类别:
相似海外基金
Affective Computing Models: from Facial Expression to Mind-Reading
情感计算模型:从面部表情到读心术
- 批准号:
EP/Y03726X/1 - 财政年份:2024
- 资助金额:
$ 38.63万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 38.63万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 38.63万 - 项目类别:
Standard Grant
Affective Computing Models: from Facial Expression to Mind-Reading ("ACMod")
情感计算模型:从面部表情到读心术(“ACMod”)
- 批准号:
EP/Z000025/1 - 财政年份:2024
- 资助金额:
$ 38.63万 - 项目类别:
Research Grant
Individual differences in affective processing and implications for animal welfare: a reaction norm approach
情感处理的个体差异及其对动物福利的影响:反应规范方法
- 批准号:
BB/X014673/1 - 财政年份:2024
- 资助金额:
$ 38.63万 - 项目类别:
Research Grant
Interface: Transplants, Aesthetics and Technology (Previously About Face: The affective and cultural history of face transplants)
界面:移植、美学和技术(之前关于面部:面部移植的情感和文化历史)
- 批准号:
MR/Y011627/1 - 财政年份:2024
- 资助金额:
$ 38.63万 - 项目类别:
Fellowship
Tracing the brain mechanisms of affective touch.
追踪情感触摸的大脑机制。
- 批准号:
23K19678 - 财政年份:2023
- 资助金额:
$ 38.63万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Affective and Immaterial Labour in Latin(x) American Culture
拉丁美洲文化中的情感和非物质劳动
- 批准号:
AH/V015834/2 - 财政年份:2023
- 资助金额:
$ 38.63万 - 项目类别:
Fellowship
Imagination under Racial Capitalism: the Affective Salience of Racialised and Gendered Tropes of 'Black excellence'
种族资本主义下的想象力:“黑人卓越”的种族化和性别化比喻的情感显着性
- 批准号:
2889627 - 财政年份:2023
- 资助金额:
$ 38.63万 - 项目类别:
Studentship
Home/bodies: Exploring the affective experiences of people at home using scenographic practice and ecological thinking
家/身体:利用场景实践和生态思维探索人们在家中的情感体验
- 批准号:
2888014 - 财政年份:2023
- 资助金额:
$ 38.63万 - 项目类别:
Studentship