Alberta Pregnancy Outcomes and Nutrition (APrON) - Toxicant-Diet Interactions on

描述（由申请人提供）：研究表明，母体饮食（如鱼）和营养素摄入（如铁、叶酸、n-3脂肪酸）对健康分娩结果和产后神经发育极为重要。与此同时，研究表明，胎儿的健康和神经发育对神经毒性环境毒物非常敏感;经典的例子包括甲基汞（MeHg）和铅（Pb）。尽管越来越多的证据表明，营养不良可能加剧神经毒性化学品的潜在不良影响，或通过适当的营养来阻止，但对于大多数神经毒性化学品，没有关于这种饮食-毒物相互作用的详细人体研究。在这里，这样的研究提出了经典的（重金属）和新兴的（BPA和邻苯二甲酸酯）环境神经毒物暴露在一个既定的前瞻性加拿大出生队列（APrON），从而详细的营养测量可用于评估这种相互作用对儿童早期行为和认知发展。将评估各种毒物之间、饮食与毒物之间以及营养素与毒物之间的相互作用，以用于儿童发育的认知、语言、运动、情感和行为测量。各种其他修饰语，包括产妇心理健康，产妇体力活动和体重增加也可用于统计建模。预计这项独特研究的结果将为预防策略提供信息，以帮助减轻经典和新兴环境发育神经毒物的有害影响。

DESCRIPTION (provided by applicant): Research has shown maternal diet (e.g. fish) and nutrient intake (e.g. Fe, folate, n-3 fatty acids) to be extremely important for healthy birth outcomes and post-natal neurodevelopment. At the same time, studies have shown the health and neurodevelopment of the fetus to be exquisitely sensitive to neurotoxic environmental toxicants; classic examples include methylmercury (MeHg) and lead (Pb). Despite growing evidence that the potential adverse effect(s) of neurotoxic chemicals may be exacerbated by poor nutrition, or blocked by proper nutrition, for most neurotoxic chemicals there are no detailed human studies of such diet-toxicant interactions. Here such a study is proposed for both classic (heavy metals) and emerging (BPA and phthalates) environmental neurotoxicant exposures in an established prospective Canadian birth cohort (APrON), whereby detailed nutritional measurements are available for assessing such interactions on early childhood behavior and cognitive development. The interplay between various toxicants, between diet and toxicant, and between nutrients and toxicants will be evaluated for cognitive, language, motor, emotional and behavioral measures of child development. Various other modifiers including maternal mental health, maternal physical activity and weight gain are also available for statistical modeling. It is anticipated that the results of this unique study will inform preventio strategies to help mitigate the harmful effects of classic and emerging environmental developmental neurotoxicants.