Alberta Pregnancy Outcomes and Nutrition (APrON) - Toxicant-Diet Interactions on

艾伯塔省妊娠结局和营养 (APrON) - 有毒物质与饮食的相互作用

• 批准号: 8259937
• 负责人: Jonathan Wayne Martin
• 金额: $ 12.88万
• 依托单位: UNIVERSITY OF ALBERTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8259937
• 关键词: Adverse effects; Age; Alberta province; Amino Acids; Behavior; Behavioral; Biological; Birth; Birth Weight; Birth length; Characteristics; Chemicals; Child; Child Development; Cognitive; Development; Diet; Dietary intake; Dimensions; Emotional; Energy Intake; Environmental Exposure; Erythrocytes; Fatty Acids; Fatty acid glycerol esters; Female; Fetus; Fishes; Folate; Funding; Gestational Age; Goals; Grant; Head circumference; Health; Heavy Metals; Human; Infant; Infant Behavior; Intake; Iron; Language; Lead; Life; Macronutrients Nutrition; Maternal Exposure; Measurement; Measures; Mental Health; Mercury; Methylmercury Compounds; Micronutrients; Minerals; Motor; Motor Skills; Neurotoxins; Nutrient; Nutritional; Omega-3 Fatty Acids; Outcome; Parents; Perinatal; Perinatal mortality demographics; Physical activity; Postpartum Period; Pregnancy; Pregnancy Outcome; Prenatal Nutrition; Probiotics; Questionnaires; Reporting; Research; Sampling; Short-Term Memory; Small for Gestational Age Infant; Source; Spottings; Statistical Models; Techniques; Temperament; Testing; Third Pregnancy Trimester; Time; Time Study; Toddler; Toxic Environmental Substances; Trace Elements; Urine; Vitamin B6; Vitamins; Weight; Weight Gain; behavior measurement; bisphenol A; cohort; community living; disorder risk; early childhood; executive function; infant temperament; male; maternal serum; neonate; neurodevelopment; neurotoxic; nutrition; phthalates; prospective; skills; social; social communication; toxicant; toxicant interaction

DESCRIPTION (provided by applicant): Research has shown maternal diet (e.g. fish) and nutrient intake (e.g. Fe, folate, n-3 fatty acids) to be extremely important for healthy birth outcomes and post-natal neurodevelopment. At the same time, studies have shown the health and neurodevelopment of the fetus to be exquisitely sensitive to neurotoxic environmental toxicants; classic examples include methylmercury (MeHg) and lead (Pb). Despite growing evidence that the potential adverse effect(s) of neurotoxic chemicals may be exacerbated by poor nutrition, or blocked by proper nutrition, for most neurotoxic chemicals there are no detailed human studies of such diet-toxicant interactions. Here such a study is proposed for both classic (heavy metals) and emerging (BPA and phthalates) environmental neurotoxicant exposures in an established prospective Canadian birth cohort (APrON), whereby detailed nutritional measurements are available for assessing such interactions on early childhood behavior and cognitive development. The interplay between various toxicants, between diet and toxicant, and between nutrients and toxicants will be evaluated for cognitive, language, motor, emotional and behavioral measures of child development. Various other modifiers including maternal mental health, maternal physical activity and weight gain are also available for statistical modeling. It is anticipated that the results of this unique study will inform preventio strategies to help mitigate the harmful effects of classic and emerging environmental developmental neurotoxicants. PUBLIC HEALTH RELEVANCE: Research has shown maternal diet and nutrient intake to be extremely important for healthy neurodevelopment. At the same time, studies have shown the health and neurodevelopment of the fetus to be exquisitely sensitive to neurotoxic environmental toxicants; a classic example is methyl mercury. Despite growing evidence that the potential adverse effect(s) of neurotoxic chemicals may be exacerbated by poor nutrition, or blocked by proper nutrition, for most neurotoxic chemicals there are no detailed human studies of such diet-toxicant interactions. Here we propose such a study for both classic and emerging environmental neurotoxicant exposures in an established prospective birth cohort, whereby detailed nutritional measurements are available for assessing such interactions on behavior, temperament, and cognitive development.

描述（由申请人提供）：研究表明，母亲的饮食（例如鱼）和营养摄入（例如铁、叶酸、n-3 脂肪酸）对于健康的分娩结果和产后神经发育极其重要。同时，研究表明胎儿的健康和神经发育对神经毒性环境毒物极为敏感；典型的例子包括甲基汞 (MeHg) 和铅 (Pb)。尽管越来越多的证据表明，神经毒性化学物质的潜在不利影响可能会因营养不良而加剧，或因适当的营养而被阻止，但对于大多数神经毒性化学物质，尚无针对此类饮食与毒物相互作用的详细人体研究。这里提出了这样一项研究，针对已建立的前瞻性加拿大出生队列 (APrON) 中的经典（重金属）和新兴（BPA 和邻苯二甲酸盐）环境神经毒物暴露，通过详细的营养测量可用于评估这种相互作用对幼儿行为和认知发展的影响。将评估各种毒物之间、饮食与毒物之间以及营养素与毒物之间的相互作用，以评估儿童发育的认知、语言、运动、情感和行为指标。各种其他修正因素，包括产妇心理健康、产妇体力活动和体重增加，也可用于统计建模。预计这项独特研究的结果将为预防策略提供信息，以帮助减轻经典和新兴环境发育神经毒物的有害影响。 公共健康相关性：研究表明，母亲的饮食和营养摄入对于健康的神经发育极为重要。同时，研究表明胎儿的健康和神经发育对神经毒性环境毒物极为敏感；一个典型的例子是甲基汞。尽管越来越多的证据表明，神经毒性化学物质的潜在不利影响可能会因营养不良而加剧，或因适当的营养而被阻止，但对于大多数神经毒性化学物质，尚无针对此类饮食与毒物相互作用的详细人体研究。在这里，我们提出了这样一项研究，针对已建立的前瞻性出生队列中的经典和新兴环境神经毒物暴露，通过详细的营养测量可用于评估行为、气质和认知发展方面的相互作用。