Can direct pathway stimulation cause addiction-like changes in behavior?
Can direct pathway stimulation cause addiction-like changes in behavior?
批准号:
9148959
负责人:
Alexxai V Kravitz
金额:
$38.83万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
BehaviorBehavioralBiological AssayCanned FoodsCorpus striatum structureDiseaseDrug AddictionEnvironmentFoodFutureLearningMotivationMusNeuronsPathway interactionsPhenotypeProcessPsychological reinforcementStimulusTaste PerceptionTestingTimeTrainingWorkaddictioncell typeexperiencefood addictionnoveloptogeneticsreinforced behaviortherapeutic targetwillingness
中文摘要
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英文摘要
In this project, we will train mice to self-stimulate their direct pathway medium spiny neurons (dMSNs) using optogenetics. In prior work, we have found that mice find this behavior highly reinforcing. However, prior work gave mice at most 90 minutes of total training time. We plan to expand this by a factor of 100, giving the mice much more experience with this highly reinforcing behavior. We will examine behavioral changes in these mice, including assaying their motivation to receive stimulation, willingness to work for stimulation, and willingness to endure negative consequences to receive stimulation.
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