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Can direct pathway stimulation cause addiction-like changes in behavior?

Can direct pathway stimulation cause addiction-like changes in behavior?
直接通路刺激能否导致类似成瘾的行为变化?
批准号:
9148959
负责人:
Alexxai V Kravitz
金额:
$38.83万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

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英文摘要
In this project, we will train mice to self-stimulate their direct pathway medium spiny neurons (dMSNs) using optogenetics. In prior work, we have found that mice find this behavior highly reinforcing. However, prior work gave mice at most 90 minutes of total training time. We plan to expand this by a factor of 100, giving the mice much more experience with this highly reinforcing behavior. We will examine behavioral changes in these mice, including assaying their motivation to receive stimulation, willingness to work for stimulation, and willingness to endure negative consequences to receive stimulation.
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Dopaminergic control of obesity in mice
  • 批准号:
    10718973
  • 项目类别:
  • 资助金额:
    $51.68万
  • 财政年份:
    2023
  • 负责人:
    Alexxai V Kravitz
  • 依托单位:
The Role of the Direct and Indirect Striatal Pathways in Movement and Learning
  • 批准号:
    8121333
  • 项目类别:
  • 资助金额:
    $4.84万
  • 财政年份:
    2011
  • 负责人:
    Alexxai V Kravitz
  • 依托单位:
The Role of the Direct and Indirect Striatal Pathways in Movement and Learning
  • 批准号:
    8262681
  • 项目类别:
  • 资助金额:
    $3.39万
  • 财政年份:
    2011
  • 负责人:
    Alexxai V Kravitz
  • 依托单位:
Accumbal Activity Under Drug and Non-Drug Rewarded Tasks
  • 批准号:
    7223691
  • 项目类别:
  • 资助金额:
    $4.1万
  • 财政年份:
    2007
  • 负责人:
    Alexxai V Kravitz
  • 依托单位:
国内基金
海外基金
Behavioral Insights on Cooperation in Social Dilemmas
  • 批准号:
    --
  • 项目类别:
    外国优秀青年学者研究基金项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    LIEN,Jaimie Wei-Hung
  • 依托单位: