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Visual and Vestibular Percepts of Motion

运动的视觉和前庭知觉

基本信息

批准号：
8777955
负责人：
Benjamin T Crane
金额：
$ 21.51万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-12-01 至 2016-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8777955
关键词：
Acceleration Acoustic Stimulation Area Attention Bilateral Caloric Tests Clinical Cues Dependence Development Diagnosis Diagnostic Diagnostic tests Disabled Persons Discrimination Disease Dizziness Equipment and supply inventories Esthesia Exposure to External Canal Frequencies Future Goals Head Hearing Human Human Pathology Illusions Individual Investigation Irrigation Laboratories Lesion Measurement Measures Mediating Migraine Monitor Motion Motion Perception Movement Noise Online Systems Organ Pathologic Pathology Patients Perception Performance Peripheral Physicians Population Productivity Psychophysics Reflex action Rehabilitation therapy Relative (related person)Reporting Role Rotation Self Perception Semicircular canal structure Severities Side Source Speed Stimulus Symptoms System Systems Integration Techniques Test Result Testing Therapeutic Time Translations Utricle structure Vertigo Vestibular loss Vision Visit Visual Visual Motion Weight Perception Work Yaws base clinical Diagnosis clinical application disorder control falls handicapping condition improved instrument movie novel diagnostics optic flow otoconia rehabilitation strategy research clinical testing research study response screening sensory system tool vestibulo-ocular reflex visual feedback visual stimulus visual-vestibular

项目摘要

DESCRIPTION (provided by applicant): This project aims to characterize human motion perception as mediated by vision, vestibular system, and the interactions between them. The project is divided into 3 main areas: vestibular perception, visual-vestibular interaction, and visual motion perception. The vestibular perception component will focus on determination of translation, heading perception, and rotation in normal controls and individuals with unilateral and bilateral peripheral vestibular lesions in the absence of visual cues. Differences in these populations may provide better understanding of vestibular sensitivity, including potential direction biases in sensitivity in those with unilateral lesions and form the basis of future diagnostic testing. Subjects with bilateral vestibular loss may provide clues to the roll of somatic sensation on motion perception. Vision has a significant role in motion perception, and patient's dizziness symptoms can result from derangements in integration of vision and vestibular cues. The most simple interaction between visual and vestibular perception occurs during rotation near the perceptual threshold in the presence of a visible, head fixed object. Paradoxically, in this situation a visible object has been shown to decrease the motion perception threshold. We plan to study this effect with moving objects and in individuals with known pathology in the visual-vestibular integration system such as occurs in migraine associated vertigo (MAV). Using this paradigm we also plan to explore perceptual differences between self and external rotation. We also plan to study the roles visual-vestibular interaction during translation using optic flow with motion to determine heading perception, in normal controls, MAV, and vestibulopathy subjects. Through these experiments we hope to quantify the influences of vision and vestibular senses on motion perception, and how the relative importance of these influences changes in pathological states. Many prior perceptual studies have used 2-alterative forced choice (2AFC) paradigms which are scientifically rigorous, but time consuming. Potential short cuts 2AFC that will speed testing and allow possible clinical applications will be explored. Dizziness in response to visual motion such as panning of the scene on a movie screen or looking out the side window of a moving vehicle is a disorienting source of dizziness complaints in MAV patients which often limits their daily activities. We plan to investigate the potential for visual motion as a diagnostic and rehabilitation strategy in these subjects. Using a specially developed web-based application, control and MAV subjects will complete a subjective visual vertical (SVV) task. The effect of background motion will be determined as well as tolerance to the stimuli. Subjects will regularly use the application over time while periodically reporting their dizziness symptoms using validated clinical instruments. The potential diagnostic value of the task, its correlation with symptom severity, and potential as a rehabilitation strategy will be investigated.

描述（申请人提供）：本项目旨在描述人类运动感知是由视觉、前庭系统及其相互作用介导的。该项目分为3个主要领域：前庭感知、视觉-前庭互动和视觉运动感知。前庭知觉部分将侧重于确定正常对照和单侧和双侧前庭周围病变患者在没有视觉提示的情况下的平移、头部知觉和旋转。这些人群的差异可能有助于更好地了解前庭敏感度，包括单侧病变患者敏感度的潜在方向偏差，并形成未来诊断测试的基础。双侧前庭功能丧失的受试者可能为躯体感觉对运动知觉的影响提供线索。视觉在运动知觉中起着重要的作用，患者的头晕症状可能是由于视觉和前庭信号整合的紊乱。视觉和前庭感知之间最简单的相互作用发生在感知阈值附近旋转时，在可见的，头部固定的物体面前。矛盾的是，在这种情况下，一个可见的物体被证明会降低运动感知阈值。我们计划在移动物体和具有视觉-前庭整合系统已知病理的个体（如偏头痛相关性眩晕（MAV））中研究这种影响。使用这种范式，我们还计划探索自我和外部旋转之间的感知差异。我们还计划在正常对照、MAV和前庭病变受试者中，利用运动中的光流来研究翻译过程中视觉-前庭相互作用的作用。通过这些实验，我们希望量化视觉和前庭感觉对运动知觉的影响，以及这些影响的相对重要性在病理状态下如何变化。许多先前的知觉研究都使用了2- alternative forced choice （2AFC）范式，这在科学上是严格的，但耗时。潜在的捷径2AFC将加速测试并允许可能的临床应用。对视觉运动（如电影屏幕上的场景平移或向移动车辆的侧窗外看）的反应引起的头晕是MAV患者头晕主诉的一个迷失方向的来源，这通常限制了他们的日常活动。我们计划研究视觉运动作为这些受试者的诊断和康复策略的潜力。使用专门开发的基于网络的应用程序，控制和MAV受试者将完成主观视觉垂直（SVV）任务。背景运动的影响将被确定，以及对刺激的耐受性。受试者将在一段时间内定期使用该应用程序，同时使用经过验证的临床仪器定期报告其头晕症状。该任务的潜在诊断价值，其与症状严重程度的相关性，以及作为一种康复策略的潜力将被调查。