Multi-modal vestibular perception

多模态前庭知觉

• 批准号: 9172651
• 负责人: Benjamin T Crane
• 金额: $ 38.38万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9172651
• 关键词: Address; Attention; Benign; Clinical; Clinical Pathology; Cues; Darkness; Data; Discrimination; Disorientation; Dizziness; Environment; Esthesia; Evaluation; Event; Exposure to; Eye; Feeling; Frequencies; Friends; Future; Head; Hearing; Human; Individual; Labyrinth; Lead; Lesion; Measurement; Measures; Methods; Migraine; Modality; Modeling; Motion; Motion Perception; Motor; Movement; Neck; Organ; Pathology; Patient Self-Report; Patients; Pattern; Perception; Physiological; Physiology; Plant Roots; Population; Positioning Attribute; Proprioception; Psychometrics; Public Health; Reflex action; Reporting; Resources; Retina; Rotation; Sensory; Severities; Side; Source; Stimulus; Symptoms; System; Techniques; Testing; Translations; Vertigo; Vision; Visual Fields; Visual Motion; Walking; Work; auditory stimulus; clinical investigation; clinically relevant; clinically significant; experience; experimental study; fall risk; falls; improved; insight; motion sensitivity; neurophysiology; optic flow; patient population; public health relevance; research clinical testing; sensory stimulus; somatosensory; vestibular reflex; visual stimulus; visual-vestibular

DESCRIPTION (provided by applicant): Dizziness and vertigo are common clinical problems rooted in abnormal perception of movement. Clinical testing of the vestibular system and understanding of vestibular physiology has historically focused on simple stimuli and reflex function. However, vestibular reflex function is poorly correlated with perceptual symptoms. In other sensory modalities perceptual testing is the first line of clinical investigation. For instane an evaluation of vision usually begins with having the patient report what they are able to see and evaluation of hearing begins with testing what the patient is able to hear. However, understanding of vestibular perception is not yet at a state where perceptual testing is clinically meaningful. Most of the previous work on vestibular perception has focused on measurement of perceptual thresholds - essentially determining if someone can sense the direction of an isolated movement in a dark room. This situation does not address the more clinically relevant situations in which each movement occurs in the context of ongoing motion which include both translation and rotation components as well as other sensory stimuli such as motor and proprioception. The current proposal aims to advance understanding of human motion perception into a clinically and physiologically relevant arena by examining this perception in an appropriate context. The project will also test psychometric methods to determine which is most appropriate for measurement of vestibular biases. Some combinations of head rotation and translation are more benign and likely to occur during ambulation while others may be indicative of a perturbation that may lead to a fall. The project will look how proceeding movements influence motion perception such that a movement that is similar to a previous one is less likely to be perceived. It is common for people to make large voluntary movements without becoming disoriented, such as looking to the side to talk to a friend while walking. This may be easy for us because we perceive our motion in a body-centered reference frame rather than head-centered one, even though the vestibular organs are in the head. How this sensory transformation occurs will be investigated for heading estimation. Visual stimuli also provide a powerful cue to self-motion perception, especially when the visible motion involves a large part of the visual field and persists for several seconds. This perception is often referred to as vection and may also be related to motion sensitivity in some patient populations. A method of quantifying vection by comparing it with actual motion will be developed. This will be useful for determining if vection and self-motion are perceived equivalently as well as proving an objective method of assessing visual motion sensitivity.

描述（由申请人提供）：头晕和眩晕是常见的临床问题，其根源是运动感知异常。前庭系统的临床测试和前庭生理学的理解历来集中在简单的刺激和反射功能。然而，前庭反射功能与知觉症状的相关性较差。在其他感觉模态中，感知测试是临床研究的第一线。例如，视力的评估通常从患者报告他们能够看到的内容开始，听力的评估从测试患者能够听到的内容开始。然而，对前庭感知的理解还没有达到临床上感知测试的状态， 有意义的以前关于前庭感知的大部分工作都集中在感知阈值的测量上-基本上是确定某人是否能在黑暗的房间里感知到一个孤立运动的方向。这种情况没有解决临床上更相关的情况，其中每个运动发生在正在进行的运动的背景下，包括平移和旋转分量以及其他感官刺激，如运动和本体感受。目前的建议旨在通过在适当的背景下检查这种感知，将人类运动感知的理解推进到临床和生理相关的竞技场。该项目还将测试心理测量方法，以确定哪种方法最适合测量前庭偏差。头部旋转和平移的一些组合是更良性的，并且可能在截肢期间发生，而其他组合可能指示可能导致跌倒的扰动。该项目将研究进行中的运动如何影响运动感知，使得与前一个运动相似的运动不太可能被感知。人们通常会在不迷失方向的情况下进行大范围的自愿运动，例如在走路时看向一边与朋友交谈。这对我们来说可能很容易 因为我们在以身体为中心的参照系中感知我们的运动，而不是以头部为中心的参照系，即使前庭器官在头部。如何发生这种感觉的转变将被调查的航向估计。视觉刺激也为自我运动知觉提供了强有力的线索，特别是当可见运动涉及大部分视野时， 持续几秒钟。这种感知通常被称为向量，并且在某些患者群体中也可能与运动敏感性有关。将发展一种通过与实际运动比较来量化矢量的方法。这将是有用的，以确定是否矢量和自我运动的感知等同，以及证明一个客观的方法来评估视觉运动敏感性。