Multi-modal vestibular perception

多模态前庭知觉

• 批准号: 9898097
• 负责人: Benjamin T Crane
• 金额: $ 32.73万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9898097
• 关键词: Acceleration; Acoustic Neuroma; Acute; Attention; Auditory; Brain Concussion; Calibration; Characteristics; Chronic; Clinical; Complex; Cues; Data; Dementia; Disease; Dizziness; Environment; Etiology; Evaluation; Exhibits; Exposure to; Functional disorder; Future; Gentamicins; Hearing; Human; Individual; Lesion; Longitudinal Studies; Measures; Meniere' s Disease; Methods; Migraine; Motion; Motion Perception; Motion Sickness; Movement; Pathologic; Pathology; Patients; Perception; Physiological; Physiology; Plant Roots; Play; Population; Process; Proprioception; Reflex action; Rehabilitation therapy; Reporting; Reproducibility; Role; Rotation; Self Perception; Sensory; Side; Stimulus; Symptoms; System; Techniques; Testing; Therapeutic; Time; Translations; Vertigo; Vestibular loss; Vision; Visual; Visual Fields; Visual Motion; Visual system structure; Work; clinical investigation; clinically significant; experience; fall risk; improved; multimodality; multisensory; novel; otoconia; research clinical testing; sensory stimulus; sensory system; tool; vestibular reflex; virtual environment; virtual reality simulation; visual stimulus; visual-vestibular

Project Summary Dizziness, vertigo, motion sickness, and simulator sickness are common clinical problems rooted in abnormal perception of movement. Clinical testing of the vestibular system and understanding of vestibular physiology has historically focused on reflex function and perception of isolated vestibular stimuli. However, vestibular reflex function is poorly correlated with perceptual symptoms. Perception of self-motion is at the root of understanding navigation, dizziness, motion sickness, and simulator sickness. Self-motion perception is also multi-sensory and primarily involves the vestibular and visual systems, although auditory and proprioception also may play a role in some situations. In many common clinical disorders, perceptual testing is the first line of clinical investigation. For instance an evaluation of vision usually begins with having the patient report what they are able to see and evaluation of hearing begins with testing what the patient is able to hear. However, understanding of self-motion perception is not yet at a state where perceptual testing is clinically meaningful. Most of the previous work on vestibular perception has focused on unimodal stimuli of perceptual thresholds and tests of visual vertical which do not address the more complex multisensory situations in which self-motion is usually experienced. The current proposal aims to advance understanding of human motion perception into a clinically and physiologically relevant arena by examining this perception in an appropriate, multisensory context. The project will measure visual-vestibular integration and define the conditions where it occurs. Visual motion can be ambiguously interpreted as self-motion through a fixed environment, environmental motion relative to a fixed observer, or inaccurate sensory calibration. The project will examine all of these possibilities but determining the factors involved in determining common causation which is essential for knowing if visual motion is a result of self-motion and can be integrated with vestibular cues or is the result of external motion and should be segregated. The project will also look at mechanism adaptation in two contexts – exposure to consistently offset visual and inertial stimuli and exposure to a rotating environment. This will be examined in normal controls but also individuals with unilateral loss of vestibular function. Developing a method of adaptation that is effective in vestibular pathology will be helpful in developing tools that are potential methods of future vestibular rehabilitation.

项目摘要 眩晕、眩晕、晕动病和模拟器晕车是常见的临床问题，根源于 对运动的不正常感觉。前庭系统的临床测试及对前庭的认识 生理学历来侧重于反射功能和对孤立的前庭刺激的感知。然而， 前庭反射功能与知觉症状相关性较差。对自我运动的感知是根本 了解导航、头晕、晕动病和模拟器晕车。自我运动感知是 也是多感官的，主要涉及前庭和视觉系统，尽管是听觉和 本体感觉在某些情况下也可能起作用。在许多常见的临床疾病中，知觉测试 是临床研究的第一线。例如，视力评估通常从拥有 患者报告他们能看到什么，听力评估从测试患者能看到什么开始 听见。然而，对自我运动知觉的理解还没有达到知觉测试的状态 临床上有意义。前庭知觉的研究主要集中在前庭的单峰刺激上。 视觉垂直的知觉阈值和测试，不涉及更复杂的多感觉 通常会经历自我运动的情况。目前的建议旨在增进对 人类运动知觉进入临床和生理相关的领域，通过在一个 适当的、多感官的语境。该项目将测量视觉-前庭整合并定义 它发生的条件。视觉运动可以模糊地解释为通过固定的 环境、相对于固定观察者的环境运动或不准确的感官校准。该项目 我将研究所有这些可能性，但确定确定共同因果关系所涉及的因素 这对于了解视觉运动是否是自我运动的结果以及是否可以与前庭整合是至关重要的 暗示或是外部运动的结果，应该分开。该项目还将研究机制 在两种情况下的适应-暴露于持续抵消的视觉和惯性刺激和暴露于 旋转环境。这将在正常对照中进行检查，但也将在单侧缺失的个体中进行检查 前庭功能。开发一种在前庭病理学中有效的适应方法将有助于 开发工具，作为未来前庭康复的潜在方法。