2015 RNA Editing Gordon Research Conference & Gordon Research Seminar

2015年RNA编辑戈登研究会议

基本信息

批准号：
8837727
负责人：
Jane Elizabeth Jackman
金额：
$ 0.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-01 至 2016-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8837727
关键词：
Address Affect Area Caliber Cell physiology Chemistry Collaborations Communicable Diseases Computational Biology Country DNA Data Development Diagnosis Diagnostic Disease Ensure Environment Equilibrium Etiology Event Female Fostering Future Gene Expression Profile Generations Genetic Genome Goals Growth HIV Health Human Immune System Diseases Immune response Immunity Infection Inflammation Interdisciplinary Study International Lead Link Malignant Neoplasms Methods Minority Modification Molecular Profiling Nervous System Physiology Neuronal Plasticity Nucleic Acids Nucleotides Oral Participant Pathology Play Policies Postdoctoral Fellow Process Prokaryotic Cells RNA RNA Editing Reaction Research Research Personnel Resources Role Scientist Staging Stress Students Time Training Virus Virus Diseases base biological systems career design developmental disease doctoral student driving force flexibility genetic information human disease improved interdisciplinary approach meetings member next generation novel outcome forecast pathogen personalized medicine posters programs public health relevance symposium tumor willingness

项目摘要

DESCRIPTION (provided by the applicant): Genetic information is often altered at the nucleotide level by RNA or DNA editing. This nucleic acid modifying process is essential for generating diversity in numerous biological systems, from simple prokaryotes to humans. Importantly, RNA and DNA editing and modification processes play a critical role in the flexible adaptation of fixed genetic information to changing conditions such as biotic and abiotic stresses, inflammation, differentiation, and infection. Moreover, different forms of RNA editing are key factors to generate neuronal plasticity and in the defense against pathogens or foreign nucleic acids. Alterations in RNA editing and modification reactions therefore have a profound impact on proper function of the nervous system, the origin and progression of malignancies and the successful battle against infectious diseases including viruses such as HIV and other pathogens. The aims of the 2015 RNA Editing GRC and GRS are to provide a forum for the presentation of cutting edge research on diverse biomedical problems that are functionally related to RNA editing, to promote strong interactions between researchers with different expertise and at different stages in their careers, to enhance the development of interdisciplinary approaches to studying RNA and DNA editing and modification and to foster the development of the next generation scientists (students, post-docs, and junior investigators). Collectively these goals will promote cross-disciplinary collaborations that will result in new research approaches aimed at understanding host-pathogen interactions and disease etiology that will ultimately lead to improved methods for the treatment and diagnosis of multiple human diseases impacted by RNA and/or DNA editing processes.

描述（应用程序提供）：遗传信息通常通过RNA或DNA编辑在核水平上改变。这种核酸修饰过程对于从简单原核生物到人类的众多生物系统产生多样性至关重要。重要的是，RNA和DNA编辑和修饰过程在固定遗传信息对变化条件（例如生物和非生物应力，炎症，分化和感染）的柔性适应中起着关键作用。此外，不同形式的RNA编辑是产生神经元可塑性和防御病原体或外核酸的关键因素。因此，RNA编辑和修饰反应的改变对神经系统的适当功能，恶性肿瘤的起源和进展以及与传染病的成功斗争具有深远的影响，包括HIV和其他病原体等病毒。 The aims of the 2015 RNA Editing GRC and GRS are to provide a forum for the presentation of cutting edge research on diverse biomedical problems that are functionally related to RNA editing, to promote strong interactions between researchers with different expert and at different stages in their careers, to enhance the development of interdisciplinary approaches to studying RNA and DNA editing and modification and to foster the development of the next generation scientists (students, post-docs, and junior调查人员）。这些目标总的来说，这些目标将促进跨学科的合作，这将导致旨在理解宿主病原体相互作用和疾病病因的新研究方法，这些方法最终将改善治疗和诊断受RNA和/或DNA编辑过程影响的多种人类疾病的方法。