Tissue Bank and Biomarkers Core

组织库和生物标志物核心（TBBC）是执行科罗拉多肺癌孢子项目研究所需标本的中央储存库。此外，作为肺癌相关标本的广泛资源，TBBC还在有足够的材料满足内部项目需求以外的要求时向校外研究人员提供标本。TBBC的三个主要目标是获取、表征和处理以及分发标本。这些服务的提供利用了与科罗拉多大学癌症中心组织生物库和处理共享资源的生物库和组织学操作的现有设施、基础设施和人员的密切工作关系。维持两个一般库：肿瘤库和癌前库。这两个样本库的标本均作为存档组织采集，或与临床试验核心合作，根据IRB批准的方案采集SPORE试验相关标本。除组织外，还采集辅助标本，包括血液、尿液、尿液和特殊支气管镜标本。TBBC与SPORE的生物统计学和生物信息学核心合作，还收集了相关的临床和生物学信息，这些信息可以包括在标本分布中。TBBC提供组织学和细胞学解释，制备RNA，DNA和蛋白质样本，创建TMA并对SPORE项目所需的选定标本进行分子分析。这包括由核心病理学家成员根据最新公布的WHO肺恶性和癌前病变分类系统进行组织学审查和分类。核心设计其活动以满足提案中概述的每个SPORE项目的需求。为了满足组织需求并实现项目目标，TBBC通过与项目调查人员合作确定的特定方式收集和处理组织。TBBC还合作开展项目相关研究，其中TBBC人员的专业知识可使研究设计、数据生成和数据分析受益。

The Tissue Bank and Biomarkers Core (TBBC) is the central repository of specimens necessary for the execution of the studies of the Colorado SPORE In Lung Cancer program. Furthermore, as an extensive resource for lung cancer related specimens, the TBBC also provides specimens to extramural investigators when there are adequate materials to accommodate these requests beyond the needs of the internal projects. The three primary goals of the TBBC are to procure, characterize and process, and distribute specimens. The provision of these services takes advantage of a close working relationship with the existing facilities, infrastructure, and personnel for biobanking and histology operations of the University of Colorado Cancer Center Tissue Biobanking and Processing Shared Resource. Two general banks are maintained: a tumor bank and a premalignant bank. Specimens for both of these banks are collected as archival tissue or, in collaboration with the Clinical Trials Core, SPORE trial associated specimens and are obtained under IRB approved protocols. In addition to tissue, ancillary specimens including blood, sputa, urine and special bronchoscopic specimens are collected. The TBBC, in collaboration with the Biostatistics and Bioinformatics core of the SPORE, also collects correlative clinical and biologic information that can be included in specimen distributions. The TBBC provides histologic and cytologic interpretation, prepares RNA, DNA and protein samples, creates TMAs and provides molecular analysis on selected specimens required by the SPORE projects. This includes histologic review and classification by up-to-date published WHO classification systems for malignant and pre-malignant lesions of the lung by the pathologist members of the core. The core designs its activities to meet the needs of each of the SPORE projects as outlined In the proposal. In order to meet the tissue needs and achieve the goals of the projects, the TBBC collects and processes tissues in a specific manner as determined via collaboration with project investigators. The TBBC also collaborates in the performance of project related studies in which expertise of TBBC personnel can benefit study design, data generation, and data analysis.