Tissue Bank and Biomarkers Core

组织银行和生物标记物核心(TBBC)是执行科罗拉多州肺癌孢子研究计划所必需的标本的中央储存库。此外，作为肺癌相关标本的广泛来源，TBBC还向外部调查人员提供标本，当有足够的材料满足这些要求时，超出内部项目的需要。TBBC的三个主要目标是获取、表征、加工和分发标本。这些服务的提供利用了与科罗拉多大学癌症中心组织生物库和组织学操作的现有设施、基础设施和人员的密切工作关系，共享资源。维持两家普通银行：一家肿瘤银行和一家癌前银行。这两个银行的标本都是作为档案组织收集的，或者与临床试验核心合作，收集孢子试验相关标本，并根据IRB批准的方案获得。除组织外，还收集辅助标本，包括血液、痰、尿和特殊的支气管镜标本。TBBC还与孢子的生物统计和生物信息学核心合作，收集可以包括在标本分发中的相关临床和生物学信息。TBBC提供组织学和细胞学解释，准备RNA、DNA和蛋白质样本，创建TMA，并对孢子项目所需的选定样本进行分子分析。这包括由病理学家核心成员按世卫组织最新公布的肺部恶性和癌前病变分类系统进行组织学审查和分类。核心组织设计其活动以满足提案中概述的每一个孢子项目的需要。为了满足组织需求和实现项目的目标，TBBC通过与项目调查人员的合作，以特定的方式收集和处理组织。TBBC还在项目相关研究的执行方面进行合作，在这些研究中，TBBC人员的专业知识可以帮助研究设计、数据生成和数据分析。

The Tissue Bank and Biomarkers Core (TBBC) is the central repository of specimens necessary for the execution of the studies of the Colorado SPORE In Lung Cancer program. Furthermore, as an extensive resource for lung cancer related specimens, the TBBC also provides specimens to extramural investigators when there are adequate materials to accommodate these requests beyond the needs of the internal projects. The three primary goals of the TBBC are to procure, characterize and process, and distribute specimens. The provision of these services takes advantage of a close working relationship with the existing facilities, infrastructure, and personnel for biobanking and histology operations of the University of Colorado Cancer Center Tissue Biobanking and Processing Shared Resource. Two general banks are maintained: a tumor bank and a premalignant bank. Specimens for both of these banks are collected as archival tissue or, in collaboration with the Clinical Trials Core, SPORE trial associated specimens and are obtained under IRB approved protocols. In addition to tissue, ancillary specimens including blood, sputa, urine and special bronchoscopic specimens are collected. The TBBC, in collaboration with the Biostatistics and Bioinformatics core of the SPORE, also collects correlative clinical and biologic information that can be included in specimen distributions. The TBBC provides histologic and cytologic interpretation, prepares RNA, DNA and protein samples, creates TMAs and provides molecular analysis on selected specimens required by the SPORE projects. This includes histologic review and classification by up-to-date published WHO classification systems for malignant and pre-malignant lesions of the lung by the pathologist members of the core. The core designs its activities to meet the needs of each of the SPORE projects as outlined In the proposal. In order to meet the tissue needs and achieve the goals of the projects, the TBBC collects and processes tissues in a specific manner as determined via collaboration with project investigators. The TBBC also collaborates in the performance of project related studies in which expertise of TBBC personnel can benefit study design, data generation, and data analysis.