Tissue Bank and Biomarkers Core

组织库和生物标志物核心（TBBC）是执行科罗拉多孢子肺癌项目研究所需的标本的中央储存库。此外，作为肺癌相关标本的广泛资源，当有足够的材料满足内部项目需求之外的这些要求时，TBBC还向外部调查人员提供标本。TBBC的三个主要目标是获取、鉴定和处理以及分发标本。这些服务的提供充分利用了科罗拉多大学癌症中心组织生物库和处理共享资源的现有设施、基础设施和人员与生物库和组织学操作的密切合作关系。维持两个一般银行：肿瘤银行和恶性前银行。这两个样本库的标本被收集为档案组织，或与临床试验核心合作，孢子试验相关标本，并根据IRB批准的协议获得。除组织外，还收集辅助标本，包括血液、痰、尿和特殊的支气管镜标本。TBBC与SPORE的生物统计学和生物信息学核心合作，还收集相关的临床和生物信息，这些信息可以包括在标本分布中。TBBC提供组织学和细胞学解释，准备RNA， DNA和蛋白质样品，创建tma并为孢子项目所需的选定标本提供分子分析。这包括由核心病理学家成员根据最新公布的世卫组织分类系统对肺部恶性和恶性前病变进行组织学审查和分类。核心设计其活动以满足提案中概述的每个《孢子》项目的需求。为了满足组织需求并实现项目目标，TBBC通过与项目调查员合作，以特定的方式收集和处理组织。TBBC还合作进行与项目相关的研究，其中TBBC人员的专业知识可以有利于研究设计，数据生成和数据分析。

The Tissue Bank and Biomarkers Core (TBBC) is the central repository of specimens necessary for the execution of the studies of the Colorado SPORE In Lung Cancer program. Furthermore, as an extensive resource for lung cancer related specimens, the TBBC also provides specimens to extramural investigators when there are adequate materials to accommodate these requests beyond the needs of the internal projects. The three primary goals of the TBBC are to procure, characterize and process, and distribute specimens. The provision of these services takes advantage of a close working relationship with the existing facilities, infrastructure, and personnel for biobanking and histology operations of the University of Colorado Cancer Center Tissue Biobanking and Processing Shared Resource. Two general banks are maintained: a tumor bank and a premalignant bank. Specimens for both of these banks are collected as archival tissue or, in collaboration with the Clinical Trials Core, SPORE trial associated specimens and are obtained under IRB approved protocols. In addition to tissue, ancillary specimens including blood, sputa, urine and special bronchoscopic specimens are collected. The TBBC, in collaboration with the Biostatistics and Bioinformatics core of the SPORE, also collects correlative clinical and biologic information that can be included in specimen distributions. The TBBC provides histologic and cytologic interpretation, prepares RNA, DNA and protein samples, creates TMAs and provides molecular analysis on selected specimens required by the SPORE projects. This includes histologic review and classification by up-to-date published WHO classification systems for malignant and pre-malignant lesions of the lung by the pathologist members of the core. The core designs its activities to meet the needs of each of the SPORE projects as outlined In the proposal. In order to meet the tissue needs and achieve the goals of the projects, the TBBC collects and processes tissues in a specific manner as determined via collaboration with project investigators. The TBBC also collaborates in the performance of project related studies in which expertise of TBBC personnel can benefit study design, data generation, and data analysis.