Cell, Tissue, and Molecular Analysis

细胞、组织和分子分析

• 批准号: 8742733
• 负责人: Dan TEODOR Simionescu
• 金额: $ 35.51万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742733
• 关键词: Adult; Applications Grants; Area; Biochemistry; Bioinformatics; Biological Assay; Biomedical Engineering; Biomedical Research; Biophotonics; Cell Separation; Cells; Centers of Research Excellence; Collaborations; Core Facility; Data; Derivation procedure; Development; Electron Microscopy; Engineering; Environment; Equipment; Faculty; Fostering; Funding; Future; Gene Expression; Generations; Goals; Grant; Histology; Image; Institutes; Institution; Laboratories; Laboratory Personnel; Lead; Learning; Location; Mentors; Microscopy; Molecular; Molecular Analysis; Molecular Biology; Molecular Biology Techniques; Natural regeneration; Organelles; Outcome; Qualifying; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Support; Scientist; Services; Signal Transduction; Solutions; South Carolina; Stem Cell Research; Stem cells; Techniques; Tissue Engineering; Tissues; Transfection; United States National Institutes of Health; Universities; adult stem cell; beneficiary; cost; experience; in vivo; induced pluripotent stem cell; member; nanoparticle; programs; protein expression; ranpirnase; research facility; stem cell biology; tool

Project Summary: Cell, Tissue, and Molecular Analysis Core (CTMA core) Cell, tissue and molecular biology techniques are the cornerstone of biomedical research. A major hindrance for junior faculty in conducting this research is a lack of ultramodern facilities and specialized expertise commonly found in states with major NIH funding. To advance the regenerative medicine research potential within South Carolina, we have identified three thrust areas which will serve the needs of our SC BioCRAFT COBRE projects: 1) molecular biology, 2) stem cell biology, and 3) histology and advanced imaging. Outstanding facilities and labs directed by experienced investigators with expertise in these three thrust areas have been identified and brought together under the aegis of the Core to serve the needs of both COBRE PIs, and other investigators statewide. To achieve the goals of the COBRE center, our core proposes three specific aims: 1) to promote and facilitate advanced molecular biology research, 2) to enhance histology and advanced imaging infrastructure and expertise and 3) augment adult and induced stem cell research capabilities. The Core will be directed by experienced, NIH funded scientists with complementary expertise in regenerative medicine, gene and protein expression and manipulation, adult and induced stem cells, and advanced histology, electron microscopy and biophotonics. Fully functional and generously equipped facilities in Clemson, Greenville, Spartanburg, and Charleston SC will be joined to provide support for idea development, overcoming technical challenges and leading the target projects towards significant outcomes. The core has an impressive potential and provides all the necessary equipment and expertise to serve the SC investigators. Moreover, the core will foster a collaborative mentoring environment that will serve to introduce the newest techniques available in regenerative medicine research and greatly enhance the sustainability of our ongoing COBRE initiative.

项目概要：细胞、组织和分子分析核心（CTMA核心） 细胞、组织和分子生物学技术是生物医学研究的基石。一个主要 初级教师进行这项研究的障碍是缺乏超现代化的设施和专门的 在拥有NIH主要资金的州常见的专业知识。为了推进再生医学的研究 在南卡罗来纳州，我们已经确定了三个重点领域，这将满足我们的SC的需要 BioCRAFT COBRE项目：1）分子生物学，2）干细胞生物学，3）组织学和高级 显像 杰出的设施和实验室由经验丰富的研究人员指导，他们在这三个方面都有专业知识 已经确定了一些领域，并在核心小组的主持下汇集在一起，以满足双方的需要。 COBRE PI和全州其他调查人员。为了实现COBRE中心的目标，我们的核心建议 三个具体目标：1）促进和促进先进的分子生物学研究，2）提高组织学 先进的成像基础设施和专业知识，3）加强成人和诱导干细胞研究 能力的核心将由经验丰富的NIH资助的科学家指导，他们在以下方面具有互补的专业知识： 再生医学，基因和蛋白质表达和操作，成人和诱导干细胞，以及 高级组织学电子显微镜和生物光子学 在克莱姆森、格林维尔、斯帕坦堡和查尔斯顿提供功能齐全、设备齐全的设施 SC将加入，为创意开发提供支持，克服技术挑战，并领导 以取得重大成果为目标。核心具有令人印象深刻的潜力，并提供所有 必要的设备和专业知识，为SC调查人员服务。此外，核心将促进合作 指导环境，将有助于介绍再生医学中可用的最新技术 研究，并大大提高我们正在进行的COBRE计划的可持续性。