Transnational Research Imaging Core (TRI)

跨国研究成像核心 (TRI)

• 批准号: 10670181
• 负责人: Dan TEODOR Simionescu
• 金额: $ 33.26万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670181
• 关键词: 3-Dimensional; Academic support; Address; Affect; Animal Testing; Animals; Applications Grants; Biocompatible Materials; Biomedical Engineering; Biomedical Research; Cell Culture Techniques; Cells; Centers of Research Excellence; Clinical; Clinical Data; Collaborations; Computer software; Core Facility; Data; Dedications; Degenerative Disorder; Derivation procedure; Development; Digital Radiography; Dimensions; Disease; Electrons; Engineering; Environment; Evaluation; Extramural Activities; Family suidae; Fees; Financial Support; Funding; Generations; Goals; Goat; Guidelines; Histology; Human; Image; Implant; In Vitro; Industry; Institution; Light; Livestock; Magnetic Resonance Imaging; Maintenance; Medicine; Mentors; Microscopy; Mission; Molecular; Molecular Analysis; Molecular Biology; Natural regeneration; Operating Rooms; Operative Surgical Procedures; Organ; Outcome; Phase; Pilot Projects; Population; Postoperative Care; Preclinical Testing; Protocols documentation; Public Health; Regenerative Medicine; Research; Research Support; Resources; Safety; Scientist; Services; Sheep; South Carolina; Stimulus; Technology; Testing; Therapeutic; Three-Dimensional Image; Tissue Engineering; Tissues; Translational Research; United States National Institutes of Health; Universities; Validation; X-Ray Computed Tomography; animal care; animal facility; animal imaging; bioimaging; biomaterial compatibility; biomaterial development; clinical imaging; cost; cytotoxicity; cytotoxicity test; digital; digital imaging; efficacy testing; experience; follow-up; genotoxicity; high standard; image reconstruction; imaging capabilities; imaging facilities; immunogenicity; implantation; improved; in vitro testing; in vivo; in vivo evaluation; innovation; interest; irritation; microCT; novel; pre-clinical; preclinical safety; programs; reconstruction; regenerative tissue; repaired; research clinical testing; safety testing; scaffold; stem cell biology; stem cells; sustainable resource; systemic toxicity; technological innovation; tissue regeneration; tool; translational goal; ultrasound; validation studies; voucher

Regenerative medicine and tissue engineering are innovative therapeutic approaches that hold great promise in addressing unmet clinical needs. Application of these novel products and technologies in human medicine is limited by the complexities of pre-clinical safety and efficacy testing. By comparison to states with major NIH funding, a significant obstacle for academic scientists, engineers and industry experts involved with translational regenerative medicine efforts in the State of South Carolina is the lack of resources to sustain and evolve existing core facilities by keeping up with the rapid pace of new and costly technological innovations, compliance issues and regulatory protocols needed to advance new discoveries. This hinders the generation of preliminary data for competitive NIH proposals and limits our ability to pursue applied regenerative medicine efforts to benefit the population of South Carolina. To advance the goals of tissue engineering and regenerative medicine that were established in Phases I and II by our COBRE Center (SC BioCRAFT) we propose to upgrade and further develop our original Cell, Tissue and Molecular Analysis core into a more translationally oriented core entitled Translational Research Imaging (TRI) core. This Phase III core has been envisioned as the combination of a bio-analytical thrust for advanced microscopy and imaging and a pre-clinical validation thrust for small and large animal testing. The overall mission of the TRI core is to support academic scientists, engineers and biomedical industry experts in their pursuit of pre-clinical validation of novel biomaterials and technologies and enhance their potential for competitive extramural funding. To achieve this mission, we propose two specific aims: 1) to provide cutting- edge capabilities for stem cell biology, explant analysis, in vivo cell tracking, advanced histology, light and electron imaging and 3D image reconstruction capabilities and 2) to provide state-of-the-art facilities and expertise for pre-clinical validation of regenerative medicine approaches by offering small and large animal surgery and long-term testing and imaging capabilities including digital radiography, clinical CT and MRI. Outstanding facilities and labs directed by experienced NIH-funded scientists will provide a collaborative mentoring environment to all pilot projects PIs and to scientists and engineers interested in developing regenerative medicine projects. Management of core activities and sustainability beyond the Phase III period will be facilitated by our campus-wide core management software, by establishment of user fees and by using a voucher program. The proposed TRI core, together with the complementary Biomaterials Engineering and Testing core, both very strongly supported by Clemson University, will greatly enhance research capabilities and advance the potential for creation of a regenerative medicine powerhouse within the state of South Carolina.

再生医学和组织工程是创新的治疗方法，在治疗癌症方面有很大的希望。 解决未满足的临床需求。这些新产品和新技术在人类医学中的应用， 受限于临床前安全性和有效性测试的复杂性。与拥有主要NIH的州相比， 资金是参与翻译的学术科学家、工程师和行业专家面临的一个重大障碍。 再生医学的努力在南卡罗来纳州是缺乏资源，以维持和发展现有的 通过跟上新的和昂贵的技术创新的快速步伐， 和监管协议来推动新的发现。这妨碍了初步数据的生成， 竞争性NIH的建议，并限制了我们的能力，追求应用再生医学的努力，以造福 南卡罗来纳州的人口 推进在第一阶段和第二阶段建立的组织工程和再生医学的目标 通过我们的COBRE中心（SC BioCRAFT），我们建议升级和进一步开发我们的原始细胞，组织和 分子分析核心转化为一个更注重实践的核心，名为转化研究成像（TRI） 核心这一第三阶段的核心已经被设想为生物分析推力的结合， 显微镜和成像以及用于小型和大型动物试验的临床前验证推力。 TRI核心的总体使命是支持学术科学家、工程师和生物医学行业专家 在他们追求的临床前验证新的生物材料和技术，并提高他们的潜力， 有竞争力的校外资助。为了实现这一使命，我们提出了两个具体目标：1）提供切割- 干细胞生物学、外植体分析、体内细胞跟踪、先进组织学、光和生物学等方面的尖端功能 电子成像和3D图像重建能力，以及2）提供最先进的设施， 通过提供小型和大型动物，为再生医学方法的临床前验证提供专业知识 手术和长期的测试和成像能力，包括数字X射线摄影，临床CT和MRI。 由经验丰富的NIH资助的科学家指导的优秀设施和实验室将提供一个合作 为所有试点项目PI以及对开发感兴趣的科学家和工程师提供指导环境 再生医学项目。第三阶段之后核心活动的管理和可持续性将 通过我们的校园范围内的核心管理软件，通过建立用户费用和使用 代金券计划。拟议的TRI核心，以及互补的生物材料工程和 测试核心，都非常强烈的支持，由克莱姆森大学，将大大提高研究能力， 推进在南卡罗来纳州建立再生医学中心的潜力。