Transnational Research Imaging Core (TRI)

跨国研究成像核心 (TRI)

基本信息

批准号：
10457963
负责人：
Dan TEODOR Simionescu
金额：
$ 33.26万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10457963
关键词：
3-Dimensional Academic support Address Affect Animal Testing Animals Applications Grants Biocompatible Materials Biomedical Engineering Biomedical Research Cell Culture Techniques Cells Centers of Research Excellence Clinical Clinical Data Computer software Core Facility Data Degenerative Disorder Derivation procedure Development Digital Radiography Dimensions Disease Electrons Engineering Environment Evaluation Extramural Activities Family suidae Fees Financial Support Funding Generations Goals Goat Guidelines Histology Human Image Implant In Vitro Industry Institution Light Livestock Magnetic Resonance Imaging Maintenance Medicine Mentors Microscopy Mission Molecular Molecular Analysis Molecular Biology Natural regeneration Operating Rooms Operative Surgical Procedures Organ Outcome Phase Pilot Projects Population Postoperative Care Preclinical Testing Protocols documentation Public Health Regenerative Medicine Research Research Support Resources Safety Scientist Services Sheep South Carolina Stimulus Technology Testing Therapeutic Three-Dimensional Image Tissue Engineering Tissues Translational Research United States National Institutes of Health Universities Validation X-Ray Computed Tomography animal care animal facility animal imaging bioimaging biomaterial compatibility biomaterial development bioscaffold clinical imaging cost cytotoxicity cytotoxicity test digital digital imaging efficacy testing experience follow-up genotoxicity high standard image reconstruction imaging capabilities imaging facilities immunogenicity implantation improved in vitro testing in vivo in vivo evaluation innovation interest irritation microCT microscopic imaging novel pre-clinical preclinical safety programs reconstruction regenerative tissue repaired research clinical testing safety testing stem cell biology stem cells sustainable resource systemic toxicity technological innovation tissue regeneration tool ultrasound validation studies voucher

项目摘要

Regenerative medicine and tissue engineering are innovative therapeutic approaches that hold great promise in addressing unmet clinical needs. Application of these novel products and technologies in human medicine is limited by the complexities of pre-clinical safety and efficacy testing. By comparison to states with major NIH funding, a significant obstacle for academic scientists, engineers and industry experts involved with translational regenerative medicine efforts in the State of South Carolina is the lack of resources to sustain and evolve existing core facilities by keeping up with the rapid pace of new and costly technological innovations, compliance issues and regulatory protocols needed to advance new discoveries. This hinders the generation of preliminary data for competitive NIH proposals and limits our ability to pursue applied regenerative medicine efforts to benefit the population of South Carolina. To advance the goals of tissue engineering and regenerative medicine that were established in Phases I and II by our COBRE Center (SC BioCRAFT) we propose to upgrade and further develop our original Cell, Tissue and Molecular Analysis core into a more translationally oriented core entitled Translational Research Imaging (TRI) core. This Phase III core has been envisioned as the combination of a bio-analytical thrust for advanced microscopy and imaging and a pre-clinical validation thrust for small and large animal testing. The overall mission of the TRI core is to support academic scientists, engineers and biomedical industry experts in their pursuit of pre-clinical validation of novel biomaterials and technologies and enhance their potential for competitive extramural funding. To achieve this mission, we propose two specific aims: 1) to provide cutting- edge capabilities for stem cell biology, explant analysis, in vivo cell tracking, advanced histology, light and electron imaging and 3D image reconstruction capabilities and 2) to provide state-of-the-art facilities and expertise for pre-clinical validation of regenerative medicine approaches by offering small and large animal surgery and long-term testing and imaging capabilities including digital radiography, clinical CT and MRI. Outstanding facilities and labs directed by experienced NIH-funded scientists will provide a collaborative mentoring environment to all pilot projects PIs and to scientists and engineers interested in developing regenerative medicine projects. Management of core activities and sustainability beyond the Phase III period will be facilitated by our campus-wide core management software, by establishment of user fees and by using a voucher program. The proposed TRI core, together with the complementary Biomaterials Engineering and Testing core, both very strongly supported by Clemson University, will greatly enhance research capabilities and advance the potential for creation of a regenerative medicine powerhouse within the state of South Carolina.

再生医学和组织工程是创新的治疗方法，在满足未满足的临床需求。这些新型产品和技术在人类医学中的应用是受临床前安全性和功效测试的复杂性的限制。与具有主要NIH的国家相比资金是学术科学家，工程师和行业专家的重要障碍南卡罗来纳州的再生医学努力是缺乏维持和进化现有的资源核心设施通过跟上新的和昂贵的技术创新的快速步伐，合规性问题以及提出新发现所需的监管协议。这阻碍了生成的初步数据竞争性的NIH建议和限制了我们追求应用再生医学努力的能力，以使南卡罗来纳州人口。促进在I和II阶段建立的组织工程和再生医学的目标通过我们的毛to中心（SC Biocraft），我们建议升级并进一步发展我们的原始细胞，组织和分子分析核心成一个更翻译的核心，标题为“翻译研究成像（TRI）” 核。该阶段III核心已被设想为高级生物分析推力的组合显微镜和成像以及用于大小动物测试的临床前验证推力。 TRI核心的总体任务是支持学术科学家，工程师和生物医学专家追求新型生物材料和技术的临时验证，并增强其潜力竞争性壁外资金。为了实现这一任务，我们提出了两个具体的目标：1）提供裁缝 - 干细胞生物学，外植体分析，体内细胞跟踪，晚期组织学，光和光的边缘能力电子成像和3D图像重建功能以及2）提供最先进的设施和通过提供小动物和大型动物的临床前验证临时验证的专业知识手术以及长期测试和成像功能，包括数字X线摄影，临床CT和MRI。经验丰富的NIH资助科学家指导的杰出设施和实验室将提供合作向所有试点项目的指导环境以及有兴趣开发的科学家和工程师再生医学项目。第三阶段以后的核心活动和可持续性的管理将通过我们的校园核心管理软件，建立用户费用并使用代金券计划。拟议的三核以及互补的生物材料工程和在克莱姆森大学（Clemson University）的强烈支持下，测试核心将极大地增强研究能力和促进在南卡罗来纳州建立再生医学强大的潜力。