Cell, Tissue, and Molecular Analysis

项目主任/首席调查员(最后、第一、中间)：Vyavahare Narendra R. 项目摘要：细胞、组织和分子分析核心(CTMA核心) 细胞、组织和分子生物学技术是生物医学研究的基石。一位少校 初级教员进行这项研究的障碍是缺乏超现代的设施和专门的 专业知识通常出现在拥有NIH主要资金的州。推进再生医学研究 在南卡罗来纳州的潜力，我们已经确定了三个主要领域，将满足我们的SC的需求 BioCRAFT Cobre计划：1)分子生物学，2)干细胞生物学，3)组织学和高级 成像。 由具有这三方面专业知识的经验丰富的调查人员指导的卓越设施和实验室 已确定领域，并在核心的支持下将其聚集在一起，以满足双方的需求 科布雷·派斯和其他全州调查人员。为了实现科布雷中心的目标，我们的核心建议 三个具体目标：1)促进和促进高级分子生物学研究；2)提高组织学水平 以及先进的成像基础设施和专业知识，以及3)加强成人和诱导干细胞研究 能力。核心将由经验丰富的NIH资助的科学家指导，他们在以下方面具有互补的专业知识 再生医学，基因和蛋白质的表达和操作，成体和诱导干细胞，以及 高级组织学、电子显微镜和生物光子学。 克莱姆森、格林维尔、斯帕坦堡和查尔斯顿的设施齐全、设施齐全 SC将加入，为创意开发提供支持，克服技术挑战，并领导 以取得重大成果的项目为目标。核心具有令人印象深刻的潜力，并提供所有 为SC调查员提供服务所需的设备和专业知识。此外，核心将促进一种协作 指导环境将有助于介绍再生医学中可用的最新技术 研究并极大地增强我们正在进行的Cobre计划的可持续性。 OMB编号0925-0001/0002(08/12版批准至2015年8月31日)页面续格式页面

Program Director/Principal Investigator (Last, First, Middle): Vyavahare Narendra R. Project Summary: Cell, Tissue, and Molecular Analysis Core (CTMA core) Cell, tissue and molecular biology techniques are the cornerstone of biomedical research. A major hindrance for junior faculty in conducting this research is a lack of ultramodern facilities and specialized expertise commonly found in states with major NIH funding. To advance the regenerative medicine research potential within South Carolina, we have identified three thrust areas which will serve the needs of our SC BioCRAFT COBRE projects: 1) molecular biology, 2) stem cell biology, and 3) histology and advanced imaging. Outstanding facilities and labs directed by experienced investigators with expertise in these three thrust areas have been identified and brought together under the aegis of the Core to serve the needs of both COBRE PIs, and other investigators statewide. To achieve the goals of the COBRE center, our core proposes three specific aims: 1) to promote and facilitate advanced molecular biology research, 2) to enhance histology and advanced imaging infrastructure and expertise and 3) augment adult and induced stem cell research capabilities. The Core will be directed by experienced, NIH funded scientists with complementary expertise in regenerative medicine, gene and protein expression and manipulation, adult and induced stem cells, and advanced histology, electron microscopy and biophotonics. Fully functional and generously equipped facilities in Clemson, Greenville, Spartanburg, and Charleston SC will be joined to provide support for idea development, overcoming technical challenges and leading the target projects towards significant outcomes. The core has an impressive potential and provides all the necessary equipment and expertise to serve the SC investigators. Moreover, the core will foster a collaborative mentoring environment that will serve to introduce the newest techniques available in regenerative medicine research and greatly enhance the sustainability of our ongoing COBRE initiative. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page