Magnetic Tracking and Orientation of Imaging Endoscopic Capsules

成像内窥镜胶囊的磁跟踪和定向

• 批准号: 8780506
• 负责人: Robert J Knuesel
• 金额: $ 21.06万
• 依托单位: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8780506
• 关键词: 3-Dimensional; Algorithms; Anatomy; Area; Barrett Esophagus; Biomedical Technology; Breathing; Colon; Consult; Custom; Data; Deglutition; Devices; Diagnosis; Doctor of Philosophy; Early treatment; Electronics; Elements; Endoscopes; Endoscopy; Engineering; Environment; Esophagus; Film; Gastroenterology; Gastrointestinal tract structure; Hour; Image; Institutes; Large Intestine; Lesion; Location; Magnetism; Malignant neoplasm of esophagus; Marketing; Measures; Mechanics; Medical; Medical Device; Medicine; Methods; Minnesota; Morbidity - disease rate; Morphologic artifacts; Motion; Operative Surgical Procedures; Organ; Outcome; Patients; Peristalsis; Phase; Physicians; Positioning Attribute; Principal Investigator; Property; Qualifying; Radiofrequency Interstitial Ablation; Relative (related person); Research; Research Personnel; Risk; Robotics; Sedation procedure; Small Business Innovation Research Grant; Small Intestines; Solutions; Source; Staging; Stomach; Surgeon; System; Technology; Testing; Time; Travel; Universities; Update; Visual; Work; base; capsule; commercialization; data acquisition; design; experience; gastrointestinal; gastrointestinal system; image registration; improved; innovation; magnetic field; nanorobotics; prevent; professor; programs; prototype; public health relevance; research and development; sensor; solid state

DESCRIPTION (provided by applicant): Prior to the advent of capsule endoscopes (CE), imaging and examination of the small bowel was difficult. Today, a patient swallows the capsule with an imaging camera, which is then carried passively through the gastrointestinal (GI) tract by peristalsis. The onboard camera captures images of the lumen wall several times per second over a 7-11 hour period, relaying them wirelessly to a body worn receiver where they are stored for subsequent physician review. The resulting large set of images gives the physician an unprecedented ability to examine the gastrointestinal anatomy. Although the physician is able to detect lesions through reviewing the vast number of images, it is very difficult to know where the lesion is located within the GI tract with current technology. The lack of location information slows or prevents surgeons from finding and excising a specific lesion, increasing surgery duration and morbidity. A better localization method is needed to improve the outcome of post-capsule endoscopy surgeries. Koronis Biomedical Technologies Corporation (KBT) proposes to develop a localization method for tracking endoscopic capsules based on magnetic sensing using solid-state thin-film Tunneling Magnetoresistive (TMR) technology. TMR sensors provide excellent magnetic sensitivity per sensor volume allowing integration of a 3-axis sensor assembly within the miniature capsule. Adding capsule location and orientation information to each image recorded by the device significantly improves the ability to diagnose lesions and provide a roadmap for location of needed therapy.

描述(申请人提供)：在胶囊内窥镜(CE)出现之前，小肠的成像和检查很困难。今天，患者用成像相机吞下胶囊，然后通过蠕动被动地携带胶囊通过胃肠道(GI)。机载摄像头在7-11个小时内每秒多次捕捉管腔壁的图像，将这些图像无线转发到穿戴在身上的接收器，在那里存储这些图像以供医生随后检查。由此产生的大量图像使医生具有前所未有的能力来检查胃肠道解剖结构。虽然医生能够通过查看大量的图像来检测病变，但使用当前的技术很难知道病变位于胃肠道内的什么位置。缺乏位置信息会减缓或阻止外科医生发现和切除特定的病变，增加手术持续时间和发病率。需要一种更好的定位方法来改善囊后内窥镜手术的结果。Koronis Biomedical Technologies Corporation(KBT)建议开发一种基于固态薄膜隧道磁阻(TMR)技术的磁传感内窥镜胶囊跟踪定位方法。TMR传感器在每个传感器体积上提供出色的磁敏感度，允许在微型胶囊内集成3轴传感器组件。将胶囊位置和方向信息添加到该设备记录的每个图像中，显著提高了诊断病变的能力，并为所需治疗的位置提供了路线图。