2020 Immunometabolism in Health and Disease GRC

2020 健康与疾病中的免疫代谢 GRC

• 批准号: 9912281
• 负责人: Hongbo Chi
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912281
• 关键词: Academia; Address; Allergic; Atherosclerosis; Atmosphere; Autoimmunity; Bioenergetics; Cell physiology; Cells; Cellular biology; Clinical; Collaborations; Communicable Diseases; Conflict (Psychology); Consultations; Country; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Ensure; Entrepreneurship; Equilibrium; Fostering; Goals; Health; Host Defense; Human; Hypersensitivity; Immune; Immune System Diseases; Immune response; Immunity; Immunology; Industrialization; Industry; Infection; Inflammatory Response; International; Intervention; Investigation; Learning; Lymphocyte Function; Lymphoid; Lymphoid Cell; Malignant Neoplasms; Mediating; Metabolic; Metabolic Diseases; Metabolic Pathway; Metabolism; Methods; Minority; Minority Groups; Mission; Modeling; Myelogenous; Myeloid Cells; National Institute of Allergy and Infectious Disease; Natural Immunity; Nature; Obesity; Oral; Peer Review; Pharmacologic Substance; Research; Research Personnel; Resolution; Rhode Island; Role; Science; Scientist; Second Messenger Systems; Seeds; Sterols; T-Lymphocyte; Technology; Therapeutic; Time; Training; Translations; Underrepresented Minority; United States; Universities; Woman; Work; adaptive immunity; career; catalyst; immune function; improved; innovation; insight; interest; meetings; member; microbiota; new therapeutic target; next generation; posters; programs; sensor; symposium; therapeutic target; tumor immunology; tumor microenvironment

Project Summary/Abstract The 2020 Gordon Research Conference (GRC) on Immunometabolism in Health and Disease, subtitled `Cellular metabolism in immunity: basic and translational', will be the inaugural GRC on the interface of cellular metabolism and immunity (or “immunometabolism”), a cutting-edge, emerging field in immunology. Recent studies indicate that cellular metabolism serves as both a fundamental mechanistic driver of and intervenable therapeutic target in infectious, allergic, and other immune-mediated diseases. The realization that metabolism is reprogrammed during the immune response and that bioenergetic and other metabolites are `repurposed' to modulate immune functions has led to a recent paradigm shift. As this young and interdisciplinary field accelerates, there is a critical need to convene experts and trainees alike. To this end, we are holding a meeting at Bryant University in Smithfield, Rhode Island from June 21–26, 2020. We are assembling international experts, both from academia and industry, on the role of cellular metabolism in the programming of myeloid and lymphoid immune cells in immunity and disease, and thus expect to foment productive, high-level discussions and collaborations, as well as significant interest among early-career investigators and trainees. Among the Specific Aims of our meeting are presentation of cutting-edge unpublished science, discussion and resolution of current controversies in the field, identification/prioritization of unmet needs in the field, stimulation of new collaborations, and provision of a comfortable and productive forum for trainees and early-stage investigations to learn and share their findings. The Co-Chairs, Drs. Michael Fessler and Hongbo Chi, in consultation with the Vice Chairs (Drs. Jeffrey Rathmell and Kathryn Moore) and other field leaders, have planned nine oral sessions to promote dialogue among established leaders in immunometabolism and emerging experts ranging from trainees to early-career scientists: Session 1 - Repurposing of Bioenergetics in Innate Immunity and Short Talks. Session 2 - Metabolic Programming of Lymphocyte Function. Session 3 - Trained Immunity, and Short Talks. Session 4 - Sterols in Immunity. Session 5 - Immunity and Microbiota as a Driver of Metabolic Disease. Session 6 - Immunometabolism of the Tumor Microenvironment. Session 7 - Metabolism in Host Defense, and Short Talks. Session 8 - Cell Fate in Immunometabolism. Session 9 - Emerging Opportunities for Intervening upon Immunometabolism in Disease. The speakers and discussion leaders are diverse and inclusive, including women (29%), early-stage investigators (16%), underrepresented minority groups (10%) and international experts from five countries outside the US. The focus of our conference directly meets the mission and goals of NIAID towards advancing intervenable insights into infectious, allergic, and immune-mediated diseases, and we are honored to invite members of NIAID administration as attendees. Our meeting agenda addresses diverse topics related to the crosstalk between immunity and metabolism in myeloid and lymphoid cells in immune- mediated diseases, including infection, allergy, autoimmunity, cancer, atherosclerosis, obesity, and diabetes.

项目总结/摘要 2020年戈登研究会议（GRC）在健康和疾病的免疫代谢，副标题 “免疫中的细胞代谢：基础和预防”，将是关于细胞代谢界面的首届GRC。 代谢和免疫（或“免疫代谢”），在免疫学的前沿，新兴领域。最近 研究表明，细胞代谢既是一个基本的机械驱动器， 感染性、过敏性和其他免疫介导疾病的治疗靶点。意识到新陈代谢 在免疫反应过程中被重新编程，生物能和其他代谢物被“重新利用”， 调节免疫功能导致了最近的范式转变。作为一个年轻的跨学科领域 加速，迫切需要召集专家和受训人员。为此，我们正在举行一次会议， 2020年6月21日至26日在罗得岛史密斯菲尔德的布莱恩特大学举行。我们正在集结国际 来自学术界和工业界的专家，对细胞代谢在骨髓细胞编程中的作用， 淋巴免疫细胞在免疫和疾病中的作用，因此有望引发富有成效的高层次讨论 和合作，以及早期职业调查人员和受训人员的重大兴趣。中 我们会议的具体目的是介绍前沿未发表的科学，讨论和解决方案 目前在外地存在的争议，查明外地未满足的需求并确定其优先次序， 合作，并为学员和早期调查提供舒适和富有成效的论坛 来学习和分享他们的发现共同主席迈克尔·费斯勒博士和迟洪波博士经与联合国秘书长协商， 副主席（Jeffrey拉斯梅尔博士和Kathryn摩尔博士）和其他外地领导人计划举行9次口头会议 促进免疫代谢领域的知名领导者和新兴专家之间的对话， 学员到早期职业科学家：第1次会议-在先天免疫和简短的谈话中重新利用生物能量学。 会议2 -淋巴细胞功能的代谢程序。第三节-训练免疫力和简短的谈话。 第四节--会议5 -免疫和微生物群作为代谢性疾病的驱动因素。 第6节-肿瘤微环境的免疫代谢。第7节-宿主防御中的代谢，以及 简短的谈话。会议8 -免疫代谢中的细胞命运。第9节----干预的新机会 疾病中的免疫代谢演讲者和讨论领导人是多样化和包容性的，包括 妇女（29%）、早期调查人员（16%）、代表性不足的少数群体（10%）和国际 来自美国以外五个国家的专家。我们会议的重点直接符合的使命和目标， NIAID致力于推进对传染性、过敏性和免疫介导疾病的可干预见解，我们 很荣幸邀请NIAID管理层成员作为与会者。我们的会议议程涉及各种 与免疫系统中骨髓和淋巴细胞中免疫和代谢之间的串扰相关的主题- 在一些实施方案中，所述药物组合物可用于治疗或预防由疾病介导的疾病，包括感染、变态反应、自身免疫、癌症、动脉粥样硬化、肥胖症和糖尿病。