权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Improving Care for Nursing Home residents with Diabetes and Cognitive Impairment

改善对患有糖尿病和认知障碍的疗养院居民的护理

基本信息

批准号：
9953776
负责人：
Sei Lee
金额：
$ 18.16万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-15 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9953776
关键词：
Admission activity Aging Alzheimer&apos s disease related dementia American Benefits and Risks Caring Clinical Clinical Research Cognitive Data Data Set Dementia Dependence Diabetes Mellitus Elderly Electronic Health Record Faculty Funding Future Glucose Glycosylated hemoglobin A Goals Guidelines Home Nursing Care Hypoglycemia Impaired cognition Insulin Intervention Investigator-Initiated Research Laboratories Lead Leadership Life Expectancy Link Measurement Measures Mentors Mentorship Metformin Microvascular Dysfunction Modeling Monitor Nursing Homes Outcome Patients Persons Pharmaceutical Preparations Pharmacoepidemiology Population Public Health Publishing Research Research Personnel Research Support Risk Severities Symptoms System Time United States Department of Veterans Affairs Validation Veterans Work adverse outcome care outcomes career career development clinical care clinical practice colorectal cancer screening disadvantaged background evidence base glucose monitor high risk improved improved outcome interest mortality nursing home length of stay older patient overtreatment personalized care programs skills

项目摘要

Public Health Significance: Nursing home (NH) residents with diabetes and Alzheimer’s disease and related dementias are a large, growing population at high risk for adverse outcomes. Unfortunately, little is known about current clinical care practices or the outcomes that result from those care practices in NH residents with diabetes and Alzheimer’s disease and related dementias. The proposed studies will examine those clinical practices and outcomes in NH residents with diabetes across the spectrum of severity of Alzheimer’s disease and related dementias. Research Aims: The proposed projects will compare the rates of fingerstick glucose measurement across the spectrum of severity of Alzheimer’s disease and related dementias (Aim 1), compare the rates of mild hypoglycemia (defined as American Diabetes Association or ADA level 1: glucose 70-54 mg/dL) and moderate hypoglycemia (ADA level 2: glucose <54 mg/dL) across the spectrum of severity of Alzheimer’s disease and related dementias (Aim 2) and determine the rates of likely glycemic overtreatment (defined as use of insulin with hemoglobin A1c or HbA1c <7.5%) and likely glycemic undertreatment (defined as use of no medications or metformin only with HbA1c >9.0%) across the spectrum of severity of Alzheimer’s disease and related dementias in long-stay nursing home residents (Aim 3). Candidate’s Career Development and Mentoring Plan: The candidate proposes to expand his successful mentorship program, taking on additional mentees to help complete the proposed projects. The candidate will continue to develop as a researcher by expanding his skills in NH research focusing on the large number of NH residents with Alzheimer’s disease and related dementias. The candidate will continue to develop as a mentor by building leadership skills and focusing on supporting mentees from disadvantaged backgrounds. Candidate’s Career Goals: Candidate’s long-term goals are to become a national leader in aging research focusing on NH residents with Alzheimer’s disease and related dementias, while becoming a pre-eminent mentor in aging research.

公共卫生意义：患有糖尿病和阿尔茨海默病及相关痴呆症的疗养院（NH）居民是一个庞大的，不断增长的人群，具有不良后果的高风险。不幸的是，我们对目前的临床护理实践或NH居民糖尿病和阿尔茨海默病及相关痴呆症患者的护理实践结果知之甚少。拟议的研究将检查NH糖尿病居民的临床实践和结果，包括阿尔茨海默病和相关痴呆症的严重程度。研究目的：拟议的项目将比较手指针刺葡萄糖测量在阿尔茨海默病和相关痴呆症严重程度范围内的比率（目标1），比较轻度低血糖的比率，（定义为美国糖尿病协会或ADA 1级：血糖70-54 mg/dL）和中度低血糖（ADA 2级：葡萄糖<54 mg/dL）的严重程度（目标2），并确定可能的血糖过度治疗的比率（定义为血红蛋白A1 c或HbA 1c <7.5%时使用胰岛素）和可能的血糖治疗不足（定义为HbA 1c>9.0%时未使用药物或仅使用二甲双胍）在长期入住养老院的居民中的阿尔茨海默病和相关痴呆的严重程度范围内（目的3）。候选人的职业发展和指导计划：候选人建议扩大他成功的指导计划，接受更多的指导者来帮助完成拟议的项目。候选人将继续发展作为一个研究人员，扩大他在NH研究的技能，重点是大量的NH居民与阿尔茨海默病和相关痴呆症。候选人将通过培养领导技能和专注于支持来自弱势背景的学员，继续发展为导师。候选人的职业目标：候选人的长期目标是成为老龄化研究的国家领导者，重点是患有阿尔茨海默病和相关痴呆症的NH居民，同时成为老龄化研究的杰出导师。