Prognostic calculators for patients with Alzheimers disease and related dementias

阿尔茨海默病和相关痴呆症患者的预后计算器

• 批准号: 9762780
• 负责人: Sei Lee
• 金额: $ 38.33万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762780
• 关键词: Admission activity; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Behavior; Blood Vessels; Body Weight decreased; Clinical; Communities; Comorbidity; Data; Data Element; Decision Making; Dementia; Dementia caregivers; Discrimination; Disease; Elderly; Eligibility Determination; Enrollment; Exposure to; Family; Fibrinogen; Goals; Health; Health and Retirement Study; Healthcare Systems; Home Nursing Care; Hospitalization; Hyperglycemia; Hypoglycemia; Individual; Intervention; Lasso; Life; Life Expectancy; Logistic Regressions; Longitudinal Studies; Maintenance; Modeling; Nursing Homes; Outcome; Participant; Patients; Persons; Physical Function; Policies; Prevention; Preventive Intervention; Quality of life; Research; Resources; Risk; Sampling; Screening for cancer; Services; Social support; Testing; Time; Validation; advanced dementia; cohort; cost; demographics; disability; experience; functional status; high risk; hospice environment; improved; mortality; mortality risk; novel strategies; online resource; outcome forecast; overtreatment; personalized decision; predictive modeling; prognostic; prognostic tool; risk prediction model; social; tool; trend

Abstract: Considering prognosis and life expectancy in patients across all stages of Alzheimer's disease and related dementias improves decision-making. Decisions that are highly influenced by prognosis for older adults with Alzheimer's disease and related dementias include cancer screening, planning financially for nursing home placement, and hospice eligibility. Despite the importance of prognosis, there are no widely-applicable, accurate, and validated tools to estimate prognosis across all stages of Alzheimer's disease and related dementias for patients living in the community. Existing models are either exclusively for persons with advanced dementia in nursing homes, outdated, or suffer from small size or non-generalizable samples. Our goal is to develop a set of clinically useful prognostic models specifically for persons with Alzheimer's disease and related dementias. To maximize the likelihood that these models are accessible to busy clinicians, we will embed these models on eprognosis.org, our online compendium of prognostic calculators. We will develop prognostic models that estimate life expectancy, time to nursing home admission, and risk of death within 6 months for persons with Alzheimer's disease and related dementias in the nationally representative Health and Retirement Study. We will externally validate these models using persons with Alzheimer's disease and related dementias enrolled in the National Health and Aging Trends Study. After validation, these models can be widely used to inform clinical and policy-level decisions for millions of Americans with Alzheimer's disease and related dementias.

抽象的： 考虑阿尔茨海默病及相关疾病各个阶段患者的预后和预期寿命 痴呆症可以改善决策能力。受老年人预后影响很大的决策 阿尔茨海默病和相关痴呆症包括癌症筛查、疗养院的财务规划 安置和临终关怀资格。尽管预后很重要，但还没有广泛适用的、 准确且经过验证的工具来估计阿尔茨海默病及相关疾病各个阶段的预后 居住在社区的痴呆症患者。现有型号要么专门针对患有以下疾病的人 疗养院中的晚期痴呆症、过时的、或者样本量小或不可概括的。我们的 目标是开发一套专门针对阿尔茨海默病患者的临床有用的预后模型 以及相关的痴呆症。为了最大限度地提高忙碌的临床医生可以使用这些模型的可能性，我们将 将这些模型嵌入 eprognosis.org（我们的在线预后计算器纲要）。我们将开发 预测预期寿命、入住疗养院的时间以及 6 年内死亡风险的预后模型 全国代表性卫生和健康部门中患有阿尔茨海默氏病和相关痴呆症的人需要几个月的时间 退休研究。我们将使用患有阿尔茨海默病的人来外部验证这些模型 相关痴呆症已纳入国家健康和老龄化趋势研究。经过验证后，这些模型可以 被广泛用于为数百万患有阿尔茨海默病的美国人提供临床和政策层面的决策信息 以及相关的痴呆症。