An assessment of whether aspirin and/or vitamin D improves breast cancer outcomes in Black women and the modifying effect of genetic variants

评估阿司匹林和/或维生素 D 能否改善黑人女性乳腺癌的预后以及遗传变异的改变作用

• 批准号: 9979777
• 负责人: Traci N. Bethea
• 金额: $ 12.75万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9979777
• 关键词: Address; Affect; African American; Age; Alleles; Antihypertensive Agents; Apoptosis; Area; Aspirin; Award; Biological; Boston; Breast Cancer Treatment; Breast Cancer survivorship; Cancer Prognosis; Cancer Survivorship; Candidate Disease Gene; Cell Cycle Progression; Cell Proliferation; Cell physiology; Cessation of life; Conflict (Psychology); DNA; Data; Development; Diagnosis; Diagnostic; Diet; Drug usage; Environmental Health; Estrogen receptor positive; Gene-Modified; Genetic; Genetic Risk; Genetic Variation; Genotype; Goals; Grant; Healthcare; IL16 gene; Inflammation; Interleukin-10; Intervention; K-Series Research Career Programs; Knowledge; Lead; Longitudinal Studies; Malignant Neoplasms; Mentors; Mentorship; Modality; Molecular Epidemiology; Neoplasm Metastasis; Non-Steroidal Anti-Inflammatory Agents; Nonmetastatic; Outcome; Participant; Pharmaceutical Preparations; Pharmacologic Substance; Physical activity; Plasma; Population; Prospective cohort study; Quality of life; Recurrence; Reporting; Research; Research Personnel; Risk; Risk Factors; Single Nucleotide Polymorphism; Sleep; Statistical Data Interpretation; Sum; Sunlight; Survival Analysis; Testing; Training; Training Activity; Translational Research; Underrepresented Populations; United States National Institutes of Health; Universities; Variant; Vitamin D; Vitamin D supplementation; Woman; Women' s Health; base; black women; breast cancer survival; cancer epidemiology; cancer health disparity; cancer recurrence; cancer survival; career; career development; cell growth; clinical practice; cohort; dietary supplements; environment related cancer; follow-up; genetic makeup; genetic variant; hazard; improved; innovation; malignant breast neoplasm; medical schools; modifiable risk; mortality; predictive modeling; professor; programs; research study; skills; survivorship

PROJECT SUMMARY/ABSTRACT The purpose of this K01 career development award submission is to support a period of didactic training and mentored research for Dr. Traci Bethea, Assistant Professor at Boston University School of Medicine, to increase her ability to carry out studies of cancer survivorship and to become an independent cancer researcher. Dr. Bethea’s long-term goal is to carry out studies that will result in a better understanding of factors that influence cancer survivorship and that will lead, ultimately, to higher survival among Black women affected by breast cancer and reduced cancer health disparities. She has already had training in environmental health and cancer epidemiology. Through the K01 training, she will develop expertise in cancer survivorship, statistical analyses of survival data, and molecular epidemiology, under the mentorship of a distinguished panel of researchers – Drs. Julie Palmer, Christine Ambrosone, Nancy Keating, Michael LaValley, and Edward Ruiz-Narváez. The mortality rate from breast cancer, the most commonly occurring cancer among women in the U.S., is 42% higher in Black women than White women. Dr. Bethea’s research will address an understudied topic, modifiable factors related to breast cancer survivorship in Black women. To this end, her proposed research utilizes data from the Black Women’s Health Study (BWHS), a longitudinal study of 59,000 African American women. During follow-up, more than 2,300 incident invasive breast cancer cases have occurred and they will be the subject of Dr. Bethea’s research. Dr. Bethea will assess several modifiable risk factors – post-diagnosis use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), and post- diagnosis use of vitamin D supplements and of predicted plasma vitamin D levels – in relation to breast cancer recurrence and breast cancer-specific mortality among breast cancer cases in the BWHS. She will create genetic risk scores using data on single nucleotide polymorphisms (SNPs) from candidate genes and will assess whether the associations of aspirin/other NSAIDs or of vitamin D supplementation and predicted plasma vitamin D levels with breast cancer recurrence and breast cancer-specific mortality are modified by genetic risk scores. Thus, Dr. Bethea will create a specific area of research in which she is highly proficient. As an independent researcher, it is anticipated that she will lead further BWHS research on cancer survivorship, which could be stand-alone studies or collaborative studies with other investigators. Dr. Bethea is an outstanding candidate. A K01 career development award will enable her to conduct important research as an independent investigator and put her on the path to obtaining NIH R01 and similar grant support and on a path to promotion. Importantly, it will also provide valuable information on factors related to breast cancer survival in Black women.

项目摘要/摘要 提交K01职业发展奖的目的是支持一段时间的教学培训和 波士顿大学医学院助理教授Traci Bethea博士的指导研究 提高她进行癌症存活率研究并成为独立癌症的能力 研究员。Bethea博士的长期目标是进行研究，以更好地了解 影响癌症存活率的因素，最终将导致黑人女性更高的存活率 受乳腺癌影响，缩小癌症健康差距。她已经接受过环境方面的培训。 健康与癌症流行病学。通过K01培训，她将发展癌症生存方面的专业知识， 在一位杰出人士的指导下，对生存数据和分子流行病学进行了统计分析 研究小组-朱莉·帕尔默博士、克里斯汀·安布罗松博士、南希·基廷博士、迈克尔·拉瓦勒博士和爱德华博士 鲁伊斯-纳尔瓦兹。乳腺癌是中国女性中最常见的癌症，其死亡率 在美国，黑人女性的比例比白人女性高42%。贝西娅博士的研究将解决 未被研究的主题，与黑人女性乳腺癌存活率相关的可改变因素。为此，她 拟议的研究利用了黑人妇女健康研究(BWHS)的数据，这是一项对59,000人进行的纵向研究 非裔美国女性。在随访期间，超过2300例浸润性乳腺癌病例 它们将成为贝西娅博士研究的对象。Bethea博士将评估几个可修改的风险 因素-诊断后阿司匹林和其他非类固醇抗炎药(NSAIDs)的使用，以及 诊断使用维生素D补充剂和预测血浆维生素D水平--与乳腺癌的关系 BWHS中乳腺癌患者的复发和乳腺癌特异性死亡率。她将创造 使用候选基因和遗嘱的单核苷酸多态(SNPs)数据进行遗传风险评分 评估阿司匹林/其他非甾体抗炎药或维生素D补充剂与预测 血浆维生素D水平与乳腺癌复发和乳腺癌特异性死亡率的关系 遗传风险得分。因此，贝西娅博士将创建一个她非常精通的特定研究领域。AS 作为一名独立研究员，预计她将领导BWHS对癌症存活率的进一步研究， 这可能是单独的研究，也可能是与其他调查人员的合作研究。贝西娅医生是一位 杰出的候选人。K01职业发展奖将使她能够作为一名 独立调查员，并使她走上了获得NIH R01和类似赠款支持的道路上，走上了一条道路 为升职干杯。重要的是，它还将提供与乳腺癌存活率相关的有价值的信息。 黑人女性。