An assessment of whether aspirin and/or vitamin D improves breast cancer outcomes in Black women and the modifying effect of genetic variants

评估阿司匹林和/或维生素 D 能否改善黑人女性乳腺癌的预后以及遗传变异的改变作用

• 批准号: 9385594
• 负责人: Traci N. Bethea
• 金额: $ 13.31万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9385594
• 关键词: Address; Affect; African American; Age; Alleles; Antihypertensive Agents; Apoptosis; Area; Aspirin; Award; Boston; Breast Cancer Treatment; Breast Cancer survivorship; Cancer Prognosis; Cancer Survivorship; Candidate Disease Gene; Cell Cycle Progression; Cell Proliferation; Cell physiology; Cessation of life; Conflict (Psychology); DNA; Data; Data Analyses; Development; Diagnosis; Diagnostic; Diet; Drug usage; Environmental Health; Epidemiology; Estrogen receptor positive; Gene-Modified; Genetic; Genetic Risk; Genetic Variation; Genotype; Goals; Grant; Healthcare; IL16 gene; Inflammation; Interleukin-10; Intervention; K-Series Research Career Programs; Knowledge; Lead; Longitudinal Studies; Malignant Neoplasms; Mentors; Mentorship; Modality; Modeling; Molecular Analysis; Molecular Epidemiology; Neoplasm Metastasis; Non-Steroidal Anti-Inflammatory Agents; Outcome; Participant; Pharmaceutical Preparations; Pharmacologic Substance; Physical activity; Plasma; Population; Prospective cohort study; Quality of life; Recurrence; Reporting; Research; Research Personnel; Risk; Risk Factors; Single Nucleotide Polymorphism; Sleep; Statistical Data Interpretation; Sum; Sunlight; Survival Analysis; Testing; Training; Training Activity; Translational Research; Underrepresented Populations; United States National Institutes of Health; Universities; Variant; Vitamin D; Vitamin D supplementation; Woman; Women' s Health; base; breast cancer survival; cancer epidemiology; cancer health disparity; cancer recurrence; cancer survival; career; career development; cell growth; clinical practice; cohort; dietary supplements; environment related cancer; follow-up; genetic makeup; genetic variant; hazard; improved; innovation; malignant breast neoplasm; medical schools; modifiable risk; mortality; professor; programs; research study; skills; survivorship

PROJECT SUMMARY/ABSTRACT The purpose of this K01 career development award submission is to support a period of didactic training and mentored research for Dr. Traci Bethea, Assistant Professor at Boston University School of Medicine, to increase her ability to carry out studies of cancer survivorship and to become an independent cancer researcher. Dr. Bethea’s long-term goal is to carry out studies that will result in a better understanding of factors that influence cancer survivorship and that will lead, ultimately, to higher survival among Black women affected by breast cancer and reduced cancer health disparities. She has already had training in environmental health and cancer epidemiology. Through the K01 training, she will develop expertise in cancer survivorship, statistical analyses of survival data, and molecular epidemiology, under the mentorship of a distinguished panel of researchers – Drs. Julie Palmer, Christine Ambrosone, Nancy Keating, Michael LaValley, and Edward Ruiz-Narváez. The mortality rate from breast cancer, the most commonly occurring cancer among women in the U.S., is 42% higher in Black women than White women. Dr. Bethea’s research will address an understudied topic, modifiable factors related to breast cancer survivorship in Black women. To this end, her proposed research utilizes data from the Black Women’s Health Study (BWHS), a longitudinal study of 59,000 African American women. During follow-up, more than 2,300 incident invasive breast cancer cases have occurred and they will be the subject of Dr. Bethea’s research. Dr. Bethea will assess several modifiable risk factors – post-diagnosis use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), and post- diagnosis use of vitamin D supplements and of predicted plasma vitamin D levels – in relation to breast cancer recurrence and breast cancer-specific mortality among breast cancer cases in the BWHS. She will create genetic risk scores using data on single nucleotide polymorphisms (SNPs) from candidate genes and will assess whether the associations of aspirin/other NSAIDs or of vitamin D supplementation and predicted plasma vitamin D levels with breast cancer recurrence and breast cancer-specific mortality are modified by genetic risk scores. Thus, Dr. Bethea will create a specific area of research in which she is highly proficient. As an independent researcher, it is anticipated that she will lead further BWHS research on cancer survivorship, which could be stand-alone studies or collaborative studies with other investigators. Dr. Bethea is an outstanding candidate. A K01 career development award will enable her to conduct important research as an independent investigator and put her on the path to obtaining NIH R01 and similar grant support and on a path to promotion. Importantly, it will also provide valuable information on factors related to breast cancer survival in Black women.

项目总结/摘要 提交K 01职业发展奖的目的是支持一段时间的教学培训， 波士顿大学医学院助理教授Traci Bethea博士指导研究， 提高她进行癌症生存研究的能力，并成为一个独立的癌症患者。 研究员Bethea博士的长期目标是开展研究，以便更好地了解 影响癌症生存率的因素，最终将导致黑人妇女的生存率更高 乳腺癌的影响和减少癌症健康差距。她已经接受过环境保护方面的培训， 健康和癌症流行病学。通过K 01培训，她将发展癌症生存方面的专业知识， 生存数据的统计分析和分子流行病学，在一位杰出的 研究小组-朱莉帕尔默博士，克莉丝汀安布罗松，南希基廷，迈克尔LaValley，和爱德华 鲁伊斯·纳瓦埃斯乳腺癌是2000年妇女中最常见的癌症， 美国，黑人女性比白色女性高42%。贝西娅博士的研究将解决 未充分研究的主题，与黑人妇女乳腺癌生存率相关的可改变因素。为此，她 一项拟议的研究利用了黑人妇女健康研究（BWHS）的数据，这是一项对59000名黑人妇女进行的纵向研究。 非裔美国女性在随访期间，超过2，300例侵袭性乳腺癌病例 它们将成为贝西娅博士的研究对象贝西娅医生将评估几种可改变的风险 因素-诊断后使用阿司匹林和其他非甾体抗炎药（NSAID），以及诊断后 维生素D补充剂的诊断使用和预测的血浆维生素D水平-与乳腺癌的关系 BWHS中乳腺癌病例的复发率和乳腺癌特异性死亡率。她将创造 使用候选基因的单核苷酸多态性（SNP）数据进行遗传风险评分， 评估阿司匹林/其他NSAID或维生素D补充剂的相关性， 血浆维生素D水平与乳腺癌复发率和乳腺癌特异性死亡率的关系通过以下方式改变： 遗传风险评分。因此，Bethea博士将创建一个她非常精通的特定研究领域。作为 作为一名独立的研究人员，预计她将领导进一步的BWHS癌症生存率研究， 这些研究可以是独立的研究，也可以是与其他研究者合作的研究。贝西娅医生是一名 优秀的候选人一个K 01职业发展奖将使她能够进行重要的研究， 独立调查员，让她走上了获得NIH R 01和类似赠款支持的道路， 晋升。重要的是，它还将提供与乳腺癌生存相关的因素的有价值的信息， 黑人女性