Biomechanics and Imaging Core

生物力学和成像核心

• 批准号: 8925777
• 负责人: Jessica E Goetz
• 金额: $ 25.28万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8925777
• 关键词: Adopted; Area; Basic Science; Biomechanics; Categories; Cellular biology; Clinical; Clinical Research; Complement; Computational Technique; Computer Simulation; Degenerative polyarthritis; Development; Disease; Elements; Environment; Equipment; Fostering; Goals; Histology; Human Resources; Image; Image Analysis; Individual; Joints; Magnetic Resonance Imaging; Measurement; Mechanical Stress; Mechanics; Methodology; Microscopic; Modeling; Molecular Biology; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Patients; Process; Protocols documentation; Quantitative Evaluations; Recording of previous events; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Running; Stress; Structure; Techniques; Testing; Translating; Validation; Work; articular cartilage; base; design; experience; falls; in vivo; in vivo Model; innovation; instrumentation; interest; meetings; member; multidisciplinary; novel; prevent

A Biomechanics and Imaging (B&I) Core is proposed to provide sophisticated technical support to all three CORT projects. Post-traumatic osteoarthritis (PTOA) results from mechanical insult to articular cartilage, and it is frequently evaluated based on a variety of imaging features. The members of the Core have an established history of developing mechanics and image analysis methodologies for quantifying particular observations of interest. The B&I Core will support the three CORT projects by achieving two specific aims. The first aim of the Core is to serve as a general technical resource comprised of advanced hardware, image analysis protocols, and personnel experienced in developing and conducting biomechanical and imaging studies. These general capabilities will be utilized as needed by the different CORT projects to support and complement both ongoing and newly evolving project activities. The second aim of the Core is to provide expert support in the areas of mechanics and image analysis which specifically enhances the work in the three CORT projects. These specialized activities can be broadly classified into four main types: computational mechanics/modeling; physical measurement and hardware design; quantitative MRI analysis; and quantitative evaluation of microscopic-level images. This variety of multidisciplinary activities best fits within the structure of a core that can support all three CORT projects simultaneously. The B&I Core provides an explicit point of overlap between the various aims of the three research projects, which allows for opportunities for the different projects to inform each other better than if the individual Core activities were segregated in the different projects. A combined mechanics and imaging core also facilitates development of unique multi-modal (e.g. stress analysis and imaging) and multi-scale (e.g. histological to clinical) imaging comparisons, which are critical to translating basic research into the clinical setting.

建议建立生物力学和成像 (B&I) 核心，为所有三个 CORT 项目提供复杂的技术支持。创伤后骨关节炎 (PTOA) 是由关节软骨机械损伤引起的，通常根据各种影像学特征进行评估。核心成员在开发力学和图像分析方法以量化感兴趣的特定观察结果方面有着悠久的历史。 B&I 核心将通过实现两个具体目标来支持三个 CORT 项目。核心的首要目标是作为通用技术资源，由先进的硬件、图像分析协议以及在开发和进行生物力学和成像研究方面经验丰富的人员组成。不同的 CORT 项目将根据需要利用这些通用功能来支持和补充正在进行的和新发展的项目活动。核心的第二个目标是在力学和图像分析领域提供专家支持，这将特别加强三个 CORT 项目的工作。这些专门活动可大致分为四种主要类型：计算力学/建模；物理测量和硬件设计；定量 MRI 分析；以及微观图像的定量评估。 这种多种多学科活动最适合能够同时支持所有三个 CORT 项目的核心结构。 B&I 核心在三个研究项目的不同目标之间提供了明确的重叠点，这使得不同项目有机会更好地相互了解，而不是将各个核心活动分开在不同的项目中。力学和成像相结合的核心还有助于开发独特的多模式（例如应力分析和成像）和多尺度（例如组织学到临床）成像比较，这对于将基础研究转化为临床环境至关重要。