Biomechanics and Imaging Core

生物力学和成像（B&I）核心建议提供先进的技术支持，所有三个CORT项目。创伤后骨关节炎（PTOA）是由关节软骨的机械损伤引起的，经常根据各种影像学特征进行评估。核心的成员有一个既定的历史发展的力学和图像分析方法，以量化特定的观察兴趣。B&I Core将通过实现两个具体目标来支持CORT的三个项目。核心的首要目标是作为一个通用的技术资源，包括先进的硬件，图像分析协议，以及在开发和进行生物力学和成像研究方面经验丰富的人员。这些一般能力将根据需要由CORT的不同项目加以利用，以支持和补充正在进行的和新发展的项目活动。核心的第二个目标是在力学和图像分析领域提供专家支持，特别是加强CORT三个项目的工作。这些专业活动可以大致分为四个主要类型：计算力学/建模;物理测量和硬件设计;定量MRI分析;和显微镜水平图像的定量评估。 这种多学科活动的多样性最适合于同时支持所有三个CORT项目的核心结构。B&I核心为三个研究项目的不同目标之间提供了一个明确的重叠点，这使得不同项目有机会相互通报，比单独的核心活动在不同项目中分开更好。结合力学和成像核心还有助于开发独特的多模态（例如应力分析和成像）和多尺度（例如组织学到临床）成像比较，这对于将基础研究转化为临床环境至关重要。

A Biomechanics and Imaging (B&I) Core is proposed to provide sophisticated technical support to all three CORT projects. Post-traumatic osteoarthritis (PTOA) results from mechanical insult to articular cartilage, and it is frequently evaluated based on a variety of imaging features. The members of the Core have an established history of developing mechanics and image analysis methodologies for quantifying particular observations of interest. The B&I Core will support the three CORT projects by achieving two specific aims. The first aim of the Core is to serve as a general technical resource comprised of advanced hardware, image analysis protocols, and personnel experienced in developing and conducting biomechanical and imaging studies. These general capabilities will be utilized as needed by the different CORT projects to support and complement both ongoing and newly evolving project activities. The second aim of the Core is to provide expert support in the areas of mechanics and image analysis which specifically enhances the work in the three CORT projects. These specialized activities can be broadly classified into four main types: computational mechanics/modeling; physical measurement and hardware design; quantitative MRI analysis; and quantitative evaluation of microscopic-level images. This variety of multidisciplinary activities best fits within the structure of a core that can support all three CORT projects simultaneously. The B&I Core provides an explicit point of overlap between the various aims of the three research projects, which allows for opportunities for the different projects to inform each other better than if the individual Core activities were segregated in the different projects. A combined mechanics and imaging core also facilitates development of unique multi-modal (e.g. stress analysis and imaging) and multi-scale (e.g. histological to clinical) imaging comparisons, which are critical to translating basic research into the clinical setting.