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Utility of Effusion Cytology and Image Analysis in the Diagnosis of Mesothelioma

积液细胞学和图像分析在间皮瘤诊断中的应用

基本信息

批准号：
9369881
负责人：
Gustavo Kunde Rohde
金额：
$ 5.52万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9369881
关键词：
Utility Effusion Cytology Image Analysis

项目摘要

Mesothelioma is a rare though often fatal disease, often associated with exposure to asbestos. The differentiation of malignant mesothelioma from benign mesothelial proliferation is often achieved by assessing tissue invasiveness from histological examination of biopsy specimens. Pleural effusion (fluid between lung and the chest wall) cytology is often a less invasive procedure that can be made available in most hospitals. Diagnosis of this malignancy from cytology specimens is often not possible, given that tissue invasiveness cannot be assessed. Our proposal details a pilot project to be conducted in collaboration with the System Chair of Pathology and Laboratory Medicine of Western Pennsylvania Health System (Jan F. Silverman, M.D.), as well as the Anatomic Pathology Medical Director of the Cleveland Clinic (Tarik M. Elsheikh, M.D.) to test an image analysis approach most recently developed by Dr. Rohde's laboratory at Carnegie Mellon University (CMU) for cancer detection directly from pleural effusion cytology. Preliminary results resulting from the application of Dr. Rohde's methods to data provided by Dr. Silverman (detailed in the application) indicates the method can potentially be useful for diagnosis of malignant mesothelioma. The objective of the pilot study would be to test the accuracy of the method developed by Dr. Rohde's laboratory in differentiating malignant mesothelioma from benign mesothelial proliferation directly from effusion cytology with a larger cohort of patients from two institutions (WPAHS and CC). If successful, the completion of the project could have a significant impact in reducing overall costs and avoiding health risks associated with invasive procedures. The successful completion of this project could also pave the way for the application of similar techniques on several similar cytopathology diagnostic and prognostic challenges.

间皮瘤是一种罕见的，但往往致命的疾病，往往与接触石棉。的恶性间皮瘤与良性间皮瘤增殖的鉴别通常通过根据活检样本的组织学检查评估组织侵袭性。胸腔积液（肺和胸壁之间的液体）细胞学检查通常是一种侵入性较小的程序，在大多数医院都有。从细胞学标本诊断这种恶性肿瘤往往不是可能，因为无法评估组织侵入性。我们的提案详细说明了一个试点项目，与西医病理学及检验医学系主任合作进行宾夕法尼亚州卫生系统（Jan F. Silverman，M.D.），以及解剖病理学医学克利夫兰诊所主任（Tarik M. Elsheikh，医学博士）测试图像分析方法最近由卡内基梅隆大学（CMU）的Rohde博士实验室开发的癌症直接从胸腔积液细胞学检测。应用的初步结果博士Rohde对Silverman博士提供的数据的方法（在申请中详细说明）表明，方法可能有助于恶性间皮瘤的诊断。试点的目标这项研究将测试罗德博士的实验室在1999年开发的方法的准确性。直接从积液鉴别恶性间皮瘤与良性间皮瘤增生来自两家机构（WPAHS和CC）的较大患者队列的细胞学检查。如果成功，该项目的完成可能会对降低总体成本和避免健康问题产生重大影响。与侵入性手术相关的风险。该项目的成功完成还可以为介绍了几种相似的细胞病理学诊断方法的应用途径，预测挑战。